- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT00851604
ProGRP, CgA, NSE and TUM2-PK in in Patients With Neuroendocrine Tumors
Evaluation of Serological Markers ProGRP, CgA, NSE and TUM2-PK in Patients With Malignant Neuroendocrine Tumors
Studieoversikt
Status
Forhold
Detaljert beskrivelse
Assessment of the anatomical spread and disease progression in neuroendocrine tumor patients has become an essential part of disease management, but sometimes in many patients difficult to be measured. Therefore, the evaluation of serum markers could represent a useful tool for monitoring the course of the disease and the response of patients to therapy or palliative treatment.Clinical data considers CgA and NSE as available today blood biomarkers for neuroendocrine tumors.Until now the usefulness of serum ProGRP as a clinical tumor marker has been evaluated mainly in Small Cell Lung Carcinoma, while its role in the management of NE tumors has not been elucidated.Available in the literature limited data suggests that ProGRP may be a potential tumor marker in NE tumors.
Pyruvate kinase type M2 is the key glycolytic regulator in tumor cells.It catalyzes the dephosphorylation of phosphoenolpyruvate to pyruvate with ATP production.The dimeric form of this enzyme (TUM2-PK) has been detected in the blood of patients with different cancers.High TUM2-PK expression was suggested to be an important element of tumor cell metabolism adaptation to an inadequate oxygen and nutrient supply.Recently, it has been shown that somatostatin and its structural analogues pass through cell membrane and actively bind to cytosolic TUM2-PK. In response to this binding TUM2-PK translocates into the nucleus and induce programmed cell death. It is suggested that TUM2-PK enzyme may contribute significantly to response of neuroendocrine tumors to somatostatin analogues.
Studietype
Registrering (Forventet)
Kontakter og plasseringer
Studiesteder
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Jerusalem, Israel, 91120
- Rekruttering
- Hadassah Medical Organization
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Ta kontakt med:
- Hadas Lemberg, PhD
- Telefonnummer: 00 972 2 6777572
- E-post: lhadas@hadassah.org.il
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Ta kontakt med:
- Arik Tzukert, DMD
- Telefonnummer: 00 972 2 6776095
- E-post: arik@hadassah.org.il
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Underetterforsker:
- Benjamin Nisman, PhD
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Underetterforsker:
- Tamar Peretz, M.D., PhD
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Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Prøvetakingsmetode
Studiepopulasjon
Beskrivelse
Inclusion Criteria:
- The patients at diagnosis of neuroendocrine tumors before therapy will be approached to participate in the study.
- Older then 18 years old
- Patients who agree to participate will receive a detailed explanation and sign an informed consent form.
Exclusion Criteria:
- Pregnant women
- Coexistence of another primary malignant tumor other then neuroendocrine tumors
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Observasjonsmodeller: Kohort
- Tidsperspektiver: Potensielle
Kohorter og intervensjoner
Gruppe / Kohort |
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1
Patients with malignant neuroendocrine tumors
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Samarbeidspartnere og etterforskere
Sponsor
Etterforskere
- Hovedetterforsker: Asher Salmon, M.D., Hadassah Medical Organization
Studierekorddatoer
Studer hoveddatoer
Studiestart
Primær fullføring (Forventet)
Studiet fullført (Forventet)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Anslag)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Anslag)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- 052508-HMO-CTIL
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