Stem Cell Transplantation With Identical Donors for Patients With Sickle Cell Disease

Inclusion criteria:

Diagnosis of severe' disease is denoted by one of the following:

• Previous central nervous system vaso-occlusive episode with or without residual neurologic findings or
• Frequent painful vaso-occlusive episodes with significant interference with normal life activities and which necessitates chronic transfusion therapy or
• Recurrent SCD chest syndrome events which necessitate chronic transfusion therapy.

Exclusion criteria:

• Patient with SCD chronic lung disease greater than or equal to stage 3
• Patient with severe renal dysfunction defined as creatinine clearance < 40 ml/min/1.73m2.
• Patient with severe cardiac dysfunction defined as echocardiogram shortening fraction < 25%.
• Patient with HIV infection.
• Pregnant or lactating.
• Patient with unspecified chronic toxicity that in the opinion of the Principal Investigator is serious enough to detrimentally affect the patient's capacity to tolerate SCT.
• Patient or patient's guardian(s) unable to understand the nature and risks inherent in the BMT process