Pravastatin and Protease Inhibitors in HIV-Infected Patients

Inclusion Criteria:

• confirmed HIV-1 infection (ELISA confirmed by Western-Blot test) ;
• Age above 18 years
• Stable antiretroviral therapy including at least one PI for >= 3 months,
• Plasma HIV-RNA level of < 50 copies/mL for >= 3 months before randomization,
• Total cholesterol > = 5.5 mmol/L with LDL-cholesterol > = 3.4 mmol/L on fasting status after three months of standardized dietary advice,
• signed informed consent

Exclusion Criteria:

• Current AIDS event or infectious disease
• Tumoral, inflammatory, muscle diseases; kidney or hepatic failure
• Psychiatric conditions
• Biological elevated muscular enzymes
• Chronic alcohol consumption
• Pregnancy