神经动员的镇痛作用
2019年10月2日 更新者：Francisco Unda Solano、Universidad Europea de Madrid
与对照组相比，神经动员对颈臂痛的镇痛作用
这些研究的目的是比较颈椎侧滑物理疗法神经动员技术与完全没有治疗的颈椎疼痛患者组的有效性。
研究概览
详细说明
颈椎侧滑 (CLG) 是一种神经组织动员技术，能够在颈臂疼痛症状发作期间实现镇痛效果。 这是通过一系列尚未完全理解的复杂生理相互作用发生的。 CLG 物理治疗技术包括颈椎和臂丛神经组织的受控运动。 CLG 产生的镇痛作用与神经组织活动性增加、水肿、炎症和神经内压降低有关，如果应用得当，除了症状暂时恶化（CLG 唯一已知的副作用）外没有任何已知的副作用，这与用于治疗颈臂痛的药物治疗产生的广泛且有时严重的副作用形成了重要对比。
据信，神经组织动员提供的痛觉减退作用是神经系统疼痛调节活性下降和相关神经组织独特生物力学特性改善的结果。尽管科学界对基于证据的疼痛治疗和神经组织动员技术 目前缺乏足够的对照双盲临床试验来衡量神经组织动员技术（如 CLG）的有效性及其对颈臂痛的具体效果。 出于这个原因，目前的研究包括在受控双盲临床试验中应用基于 CLG 神经组织动员的治疗方案，目的是评估其治疗疼痛症状的临床有效性
研究类型
介入性
注册 (实际的)
52
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
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Carabobo
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San Diego、Carabobo、委内瑞拉、02006
- "Centro Médico y de Especialidades Pediátricas Dr. José Gregorio Hernández "
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参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 至 45年 (成人)
接受健康志愿者
不
有资格学习的性别
全部
描述
纳入标准：
- 磁共振成像证实的颈臂痛临床诊断
- 在应用治疗前至少连续 3 个月出现上肢疼痛、感觉异常或麻木的单侧症状。
- 以下所有测试的阳性结果：Spurling、Distraction 和 Upper Limb
排除标准：
- 使用非甾体类抗炎药 (NSAID) 的禁忌症
- 使用任何类型的治疗、疗法、程序或药物来减轻疼痛
- 服用抗惊厥药、抗抑郁药或精神药物的患者
- 椎骨不稳定
- 脊椎骨质疏松症
- 脊椎或脊柱感染。
- 遗传、传染或肿瘤起源的神经系统疾病
- 颈椎管狭窄性脊髓病
- 怀孕
- 运动恐惧症
- 内分泌失调和更年期
- 脊柱手术史
- 智力障碍、严重精神疾病、醉酒、严重睡眠剥夺、老年痴呆症。
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：平行线
- 屏蔽：三倍
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：颈椎侧滑
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物理治疗师在 5 个不同的场合连续 2 分钟应用非手术非侵入性颈椎侧滑神经动员程序，在每 2 分钟神经动员技术应用之间休息 1 分钟。
干预在 6 周的时间内进行。
患者颈椎的正确线性对齐是通过在每次颈椎侧滑神经动员应用中使用通用测角仪设备作为基线来确定的。
其他名称：
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NO_INTERVENTION：等候名单控制组
- 分配到 6 周等候名单以接受治疗的患者
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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使用 1 小时疼痛数字评定量表从基线开始的变化
大体时间：双臂在基线时和仅在实验组应用治疗后 1 小时，对应于第 1、15 和 30 天的干预
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疼痛数字评定量表 (NRS) 是一个 11 点量表，用于患者自我报告疼痛，其中 0 分代表完全没有疼痛，10 分代表最严重的疼痛状态，它被用来评估颈臂痛的存在和缓解疼痛症状。
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双臂在基线时和仅在实验组应用治疗后 1 小时，对应于第 1、15 和 30 天的干预
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
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使用 Quik DASH 量表改变涉及受影响上肢的身体功能基线
大体时间：在基线时，对应于治疗第 1 天和第 30 天的干预
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手臂残疾快速测试 (Quick DASH) 是一种自我报告的简短问卷，旨在测量患有任何或几种上肢肌肉骨骼疾病的人的身体功能和症状。
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在基线时，对应于治疗第 1 天和第 30 天的干预
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颈椎旋转运动范围 (CROM)
大体时间：双臂在基线时和仅在实验组应用治疗后 1 小时，对应于第 1 天和第 30 天的干预
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使用颈椎运动范围装置 (CROM) 以旋转度为单位评估颈椎旋转。
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双臂在基线时和仅在实验组应用治疗后 1 小时，对应于第 1 天和第 30 天的干预
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
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研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2015年7月1日
初级完成 (实际的)
2015年10月1日
研究完成 (实际的)
2015年10月1日
研究注册日期
首次提交
2015年10月26日
首先提交符合 QC 标准的
2015年11月2日
首次发布 (估计)
2015年11月3日
研究记录更新
最后更新发布 (实际的)
2019年10月4日
上次提交的符合 QC 标准的更新
2019年10月2日
最后验证
2019年10月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.