Retrospective Review of NSAIDS in the Postpartum Period
Hypertension and NSAIDS in the Postpartum Period
研究概览
详细说明
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common medication used for pain relief in the postpartum period in the United States. For pain relief of uterine involution, NSAIDs have shown to be superior to placebo, and equivalent or superior to narcotics. In 2013 the American College of Obstetricians and Gynecologists (ACOG) discouraged the use of NSAIDs in women with pre-eclampsia due to concerns for inadvertently increasing blood pressure. This recommendation is based on non-obstetrics literature, which tended to show a small increase of blood pressures in patients who use NSAIDS. However the literature is mixed, particularly on ibuprofen which is the most common NSAID used in the postpartum. Of the two meta-analysis that are commonly referenced, Pope et al found a decrease of -0.3 (+/- 2.57) mmHg in mean arterial pressure (MAP) in patients with hypertension treated with ibuprofen, and Johnson et al identified an average of 5mmHg increase in blood pressure with ibuprofen use. A large study of 18,325 patients who were treated with NSAIDS or COX-2 inhibitors, found an average of a 2.1 (+/- 0.5) mmHg increase in blood pressure with ibuprofen administration.
There are two articles available in the obstetrics literature on the topic of NSAIDS in women with hypertension disorders. The first is by Makis et al, and is a case series of six women, with discussion of two cases. The explanations of hypertension causes are limited and possible alternate diagnoses are not discussed (6). The second by Wasden et al is a retrospective study of women who had the diagnosis of severe hypertension disorders in pregnancy. The patients were matched 2:1 for women exposed to NSAIDs versus those who did not receive NSAIDs. MAPs were compared, and there was no difference found between the two groups. This second study is better designed and is likely representative of the true outcome of NSAID use in pre-eclamptic women, as the general literature shows a small, non-clinically significant change in blood pressure readings.
研究类型
联系人和位置
学习地点
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Missouri
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Saint Louis、Missouri、美国、63117
- St. Mary's Health Center
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- received NSAIDs post delivery for pain
Exclusion Criteria:
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学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
干预/治疗 |
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NSAID use
The purpose of this study is to establish that NSAIDS are an appropriate analgesic to be used in the postpartum period, and thus women in the immediate postpartum period are the focus of this study.
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The purpose of the study is to establish that NSAIDS are an appropriate analgesic to be used in the postpartum period, and thus women in the immediate postpartum period are the focus of this study.
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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pain relief
大体时间:1 year
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to establish that NSAIDS are an appropriate analgesic to be used in the postpartum period
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1 year
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 26975
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)?
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
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Post Partum Pain的临床试验
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Kartos Therapeutics, Inc.招聘中原发性骨髓纤维化 (PMF) | 真性红细胞增多症后 MF (Post-PV-MF) | 原发性血小板增多症后 MF (Post-ET-MF)美国, 大韩民国, 德国, 澳大利亚, 匈牙利, 法国, 西班牙, 意大利, 台湾, 泰国, 巴西, 波兰, 火鸡, 以色列, 葡萄牙, 罗马尼亚, 阿根廷, 保加利亚, 加拿大, 克罗地亚, 捷克语, 立陶宛, 墨西哥, 菲律宾, 英国, 香港, 俄罗斯联邦, 希腊
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Suzhou Zelgen Biopharmaceuticals Co.,Ltd完全的原发性骨髓纤维化 (PMF) | 真性红细胞增多症后骨髓纤维化(Post-PV MF) | 原发性血小板增多症后骨髓纤维化(Post-ET MF)中国
NSAID use的临床试验
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Swedish Medical CenterNational Institute of Mental Health (NIMH); University of Washington; University of Massachusetts...招聘中
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The First Affiliated Hospital of Xiamen UniversityFirst Affiliated Hospital of Fujian Medical University; Fujian Medical University Union Hospital 和其他合作者招聘中
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Yonsei University完全的
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Medical University of ViennaMedical Scientific Fund of the Mayor of Vienna未知
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The Eye Institute of West FloridaEyePoint Pharmaceuticals, Inc.未知