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Aflibercept With and Without Micropulse Laser in Diabetic Macular Edema (MPL)

2019年7月2日 更新者：Abeer MohamedSadeck Khattab、Al Hadi Hospital

Aflibercept With Adjuvant Micro-Pulsed Yellow Laser Versus Aflibercept Monotherapy in Treatment of Diabetic Macular Edema.

prospective study evaluating the impact of subthreshold micropulsed laser on the number of Aflibercept injections when used as an adjuvant therapy in eyes with diabetic macular edema.

研究概览

地位

完全的

条件

干预/治疗

研究类型

介入性

注册 (实际的)

51

阶段

  • 第四阶段

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 科威特
    • AlJabryia
      • Ḩawallī、AlJabryia、科威特、123
        • AlHadi hospital

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年 及以上 (成人、年长者)

接受健康志愿者

不

有资格学习的性别

全部

描述

Inclusion Criteria:

  • older than 18 years old
  • diagnosed with DME with central macular thickness (CMT) more than 250 µm measured by OCT
  • best corrected visual acuity (BCVA) between 20/400 and 20/40.

Exclusion Criteria:

  • patients with intra-ocular surgery as cataract surgery within 6 months
  • prior intravitreal injection of any drug within the preceding 6 months
  • panretinal photocoagulation (PRP) within the former 4 months.
  • Patients with previous macular laser
  • patients with vitreo-macular traction (VMT) syndrome
  • severe glaucoma
  • other retinal vascular diseases
  • conditions that impede the OCT interpretation

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：治疗
  • 分配：随机化
  • 介入模型：并行分配
  • 屏蔽：无（打开标签）

武器和干预

参与者组/臂
干预/治疗
有源比较器：Group A
received aflibercept injections alone
药品：Aflibercept Injection
Group A;Under complete aseptic conditions; intravitreal aflibercept injections with dose of 2 mg/0.05 mL per injection was given for the patients. Patients were scheduled to receive 3 loading injections at monthly interval. At the 3rd month; further treatment was planned pro re nata (PRN) according to the response. Injections were discontinued when the CMT reached 250 µm or less. If there was no change in the CMT after two consecutive injections; patients shifted to other line of treatment. Reinjection was continued for the other eyes with re-evaluation of the response every month.In group B Patients received the initial 3 monthly loading doses of IVI of aflibercept followed by MPL therapy (within one week after the 3rd injection). Patients were scheduled for follow-up monthly. Injection followed by MPL was then repeated according to the response as in group A.
其他名称：
  • Micropulsed yellow laser
实验性的：Group B
received 3 aflibercept injections followed by micropulsed laser
药品：Aflibercept Injection
Group A;Under complete aseptic conditions; intravitreal aflibercept injections with dose of 2 mg/0.05 mL per injection was given for the patients. Patients were scheduled to receive 3 loading injections at monthly interval. At the 3rd month; further treatment was planned pro re nata (PRN) according to the response. Injections were discontinued when the CMT reached 250 µm or less. If there was no change in the CMT after two consecutive injections; patients shifted to other line of treatment. Reinjection was continued for the other eyes with re-evaluation of the response every month.In group B Patients received the initial 3 monthly loading doses of IVI of aflibercept followed by MPL therapy (within one week after the 3rd injection). Patients were scheduled for follow-up monthly. Injection followed by MPL was then repeated according to the response as in group A.
其他名称：
  • Micropulsed yellow laser
其他：micropulsed yellow laser
Micropulse yellow IQ 577nm laser (Iridex Corporation, Mountain View, CA, USA) was employed. The Area Centralis lens (laser spot size magnification 0.94) was utilized with 400 mw power, 200μm spot size and 200 ms pulse duration with 5% duty cycle after micropulse mode activation. Laser was applied on clinically visible thickened macula with different number of confluent non- spacing shots in 7x7 grids. Care was taken to begin treatment outside the foveal avascular zone and not to treat the fovea when there was no visible reaction. If there was any visible reaction; treatment was stopped and the power was reduced until there was no visible reaction.

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
the number of intravitreal injections
大体时间：18th month follow-up.
the total number of intravitreal aflibercept injections were recorded
18th month follow-up.
Central macular thickness
大体时间：18 month
in um
18 month

次要结果测量

结果测量
大体时间
best corrected visual acuity measured in ETDRS.
大体时间：18 months
18 months

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Al Hadi Hospital

调查人员

  • 首席研究员：Abeer M Khattab, MD、Al Hadi Hospital

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2017年5月8日

初级完成 (实际的)

2017年6月21日

研究完成 (实际的)

2018年12月28日

研究注册日期

首次提交

2019年3月1日

首先提交符合 QC 标准的

2019年3月6日

首次发布 (实际的)

2019年3月7日

研究记录更新

最后更新发布 (实际的)

2019年7月5日

上次提交的符合 QC 标准的更新

2019年7月2日

最后验证

2019年7月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • AlHadi Hospital

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

未定

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

在美国制造并从美国出口的产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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医疗条件

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条件

罕见疾病

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赞助者/合作者

地点

3
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