The Degree, Duration and Frequency of Insulin Resistance in Non-operated Patients With Sepsis
Insulin Resistance in Septic Patients in the Acute Phase and After Discharge From Hospital
研究概览
详细说明
Background: Insulin resistance is well documented after surgery in a severity positively correlated to the degree of trauma (Thorell et al. 1999; Chambrier et al. 2000). Similar phenomena have been described in severely ill patients in ICU with consequences for the survival (Van den Berghe et al. 2001; The NICE-SUGAR Study Investigators 2009). The documentation, however, is scarce and the extent is unknown in acutely ill patients with sepsis.
Method: Adult, consecutive, non-diabetic patients with elevated CRP, leukocyte counts, SOFA-score of ≥ 2 were monitored with fasting p-C-peptide, blood glucose, CRP, leukocyte count and HOMA-IR at admittance, discharge and at two follow-up visits 2 weeks and 4 weeks after admission. Blood glucose levels were measured continuously during the whole study period with a flash glucose monitor mounted on the patients' upper arm. The diagnosis was sepsis, urosepsis, pneumonia, erysipecosis, bacteremia, infection with unknow focus and covid-19.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Slagelse、丹麦、4200
- Department of endocrinology, Slagelse Hospiatl
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- elevated CRP on acute asdmission
- elevated leukocyte count on admission
- SOFA-score ≥ 2
- diagnosis: bacterial sepsis
- full age and authority
Exclusion Criteria:
- not able to understand the protocol
- not able to co-operate
- diabetes mellitus of any kind
学习计划
研究是如何设计的?
设计细节
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
continous blood glucose
大体时间:4 weeks
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flash glucose monitor on the upper arm
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4 weeks
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
C-peptide
大体时间:4 weeks
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plasma concentration
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4 weeks
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HOMA-IR
大体时间:4 weeks
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calculated glucose load test
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4 weeks
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合作者和调查者
调查人员
- 研究主任:Jens R Andersen, MD,MPA、University of Copenhagen
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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