- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00416637
Bevacizumab in Treating Patients With Advanced Solid Tumors
Biomarker and Clinical Evaluation of Bevacizumab (Avastin) to Determine the Role of Nitric Oxide in Anti-VEGF Therapy
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some find tumor cells and kill them or carry tumor-killing substances to them. Others interfere with the ability of tumor cells to grow and spread. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor .
PURPOSE: This phase I trial is studying how well bevacizumab works in treating patients with advanced solid tumors.
Study Overview
Status
Intervention / Treatment
Detailed Description
OBJECTIVES:
Primary
- Determine whether anti-vascular epidermal growth factor (VEGF) treatment comprising bevacizumab causes changes in endothelial cell function, as measured by brachial reactivity, and changes in nitric oxide (NOx), as measured by plasma/urinary/exhaled NOx levels, in patients with advanced solid tumors.
- Determine whether anti-VEGF-related changes in blood pressure correlate with changes in brachial reactivity and NOx levels.
Secondary
- Evaluate anti-angiogenic effects of bevacizumab in neovascular tissue in the wound angiogenesis model.
- Correlate inhibition of wound angiogenesis with changes in VEGF-receptor 2 phosphorylation status and changes in NOx synthase expression.
- Describe the mean and associated variability of other plasma and urine markers known to be associated with vascular reactivity, endothelial function, and/or tumor angiogenesis.
- Describe, preliminarily, whether these changes correlate with changes in blood pressure, brachial reactivity, NOx levels, or wound angiogenesis.
OUTLINE: Patients receive bevacizumab IV over 30-90 minutes on days 1, 15, and 29. After the third dose of bevacizumab, patients may receive additional bevacizumab in combination with chemotherapy in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A total of 35 patients will be accrued for this study.
Study Type
Enrollment (Anticipated)
Phase
- Phase 1
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
DISEASE CHARACTERISTICS:
Histologically confirmed solid tumor
- Metastatic or unresectable disease
- Standard curative or palliative measures do not exist or are no longer effective OR treatment with standard chemotherapy plus bevacizumab is appropriate* NOTE: *It must be judged clinically appropriate by the treating physician to delay combination treatment for the 6 weeks needed for study participation
- Patients with squamous cell non-small cell lung cancer are ineligible
PATIENT CHARACTERISTICS:
- ECOG performance status 0-2
- Absolute neutrophil count ≥ 2,000/mm³
- Platelet count ≥ 100,000/mm³
- Hemoglobin ≥ 9.0 g/dL
- AST/ALT ≤ 2.5 times upper limit of normal (ULN) (5 times ULN if known liver metastases are present)
- Creatinine clearance ≥ 50 mL/min
No proteinuria at baseline
- Patients with ≥ 1+ proteinuria during screening should undergo a timed 12- or 24-hour urine collection, which must be an adequate collection and must demonstrate < 500 mg protein/24 hr to be eligible for the study
Not pregnant or nursing
- No nursing for ≥ 4 months after completion of study treatment
- Negative pregnancy test
- Fertile patients must use effective contraception during and for ≥ 4 months after completion of study treatment
No arterial thromboembolic events within the past 6 months, including any of the following:
- Transient ischemic attack
- Cerebrovascular accident
- Unstable angina
- Myocardial infarction
- Clinically significant peripheral vascular disease
- No venous thromboembolic event within the past 3 months
- No clinically significant cardiovascular disease
- No uncontrolled hypertension
- No New York Heart Association class II or greater congestive heart failure
No serious cardiac arrhythmia requiring medication
- Atrial or supraventricular tachycardias that are well controlled with beta blockers or calcium channel blockers are allowed
- Chronic pacemakers allowed
- No presence of bleeding diathesis or coagulopathy
- No significant traumatic injury within the past 4 weeks
- No history of other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that might affect the interpretation of the results of the study or render the patient at high risk from treatment complications
PRIOR CONCURRENT THERAPY:
- No administration of nitrates within the past week
At least 2 weeks since prior and no concurrent antihypertensive agent(s)
- Must have stable blood pressure (BP) (BP < 160/100 mm Hg) within the past 2 weeks
- Must be asymptomatic within the past 2 weeks
- No open biopsy within the past 14 days
- No fine needle aspirations other than in the breast within the past 7 days
- No placement of a vascular access device within the past 7 days
- No major surgical procedure within the past 4 weeks
- No chemotherapy within the past 4 weeks (6 weeks for nitrosoureas or mitomycin C) and recovered
- No radiotherapy within the past 4 weeks
- No previous treatment with bevacizumab
- No need for major surgical procedure during the course of the study
- No other cancer immunotherapy or biologic therapy while on the study
No concurrent or recent (within past 10 days) use of full-dose oral or parenteral anticoagulants (heparin > 10,000/day or an INR > 1.5) or thrombolytic agents
- 1 mg of warfarin is permitted as required to maintain patency of preexisting, permanent indwelling IV catheters
- No chronic, daily treatment with aspirin (> 325 mg/day) or nonsteroidal anti-inflammatory medications (of the kind known to inhibit platelet function at doses used to treat chronic inflammatory diseases)
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Bevacizumab (Avastin)
Bevacizumab given and then BP checked and skin biopsies obtained.
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Herbert I. Hurwitz, MD, Duke Cancer Institute
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Pro00008011
- DUMC-4907-05-6R2
- GENENTECH-DUMC-4907-05-6R2
- CDR0000449969 (Other Identifier: NCI)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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