- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00512876
Effectiveness and Safety of Topical Bevacizumab (Avastin) for Treatment of Corneal Neovascularization
July 3, 2013 updated by: Michael J. Mines, MD, Walter Reed Army Medical Center
Purpose: To determine the efficacy and safety of one commonly used VEGF inhibitor, bevacizumab (Avastin, Genentech), as a topical agent for the treatment of corneal neovascularization.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
24
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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District of Columbia
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Washington, District of Columbia, United States, 20307
- Walter Reed Army Medical Center
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 74 years (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- male or female, at least 18 years of age
- clinically stable corneal neovascularization
- superficial or deep corneal neovascularization that extends farther than 2mm from the limbus
- ability to understand and provide informed consent to participate in this study and willingness to follow study instructions and likely to complete all required visits.
Clinical stability - all of the following criterial should be excluded before a corneal neovascularization can be regarded as clinically stable:
- current or recent (<3 months) episode of corneal and ocular surface infection (bacterial, viral, fungal, or acanthamoebal)
- recent (<3 months) ocular surgery, including cataract surgery, and/or laser of any type in the study eye
- recent (<6 months) full thickness or lamellar keratoplasty
- recent (<6 months) ocular surface reconstruction, limbal auto or allograft stem cell transplantation, or amniotic membrane transplantation
- current or recent (<3 months) use of contact lens or plan to use contact lens (excluding bandage contact lens)
- current or recent (<3 months) persistent corneal epithelial defect (of at leat 14 days duration) measuring more than 1mm2
Exclusion Criteria:
- current or recent (<1 month) systemic corticosteroid therapy or periocular corticosteroid injections to the study eye
- current or recent (<3 months) intravitreal durg injection to the study eye.
- recent (<1 month) change in dose and frequency of topical steroids and/or non-steroidal anti-inflammatory agents
- uncontrolled hypertension defined as systolic blood pressure >150 mmHg or diastolic blood pressure of >90 mmHg
- history of a thromboembolic event, including myocardial infarction or cerebral vascular accident
- patients age 75 or older
- history of renal abnormalities
- recent (<3 months) or planned surgery
- history of coagulation abnormalities, including end stage liver disease or current anticoagulation medication other than aspirin (warfarin, heparin, enoxaparin or similar anticoagulant agent)
- all female patients of childbearing potential will be excluded. A female is considered to be of childbearing potential unless she is postmenopausal and without menses for 12 months or without a uterus and/or both ovaries.
- any condition (including language barrier) that precludes patient's ability to comply with study requirements including completion of study.
- any condition that precludes the patient's ability or an assisting family member's ability to apply the medication drops or to sustain five minutes of pressure on the lacrimal ducts after drop application.
- concurrent enrollment in another clinical investigation medicinal product or device study is prohibited.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Adverse Events (Ocular and Systemic)
Time Frame: 24 weeks
|
24 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Size and Extent of Corneal Neovascularization
Time Frame: 24 weeks
|
computerized image analysis of the corneal photographs were used to measure the change in size and extent of corneal neovascularization from baseline.
|
24 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
August 1, 2007
Primary Completion (ACTUAL)
January 1, 2011
Study Completion (ACTUAL)
January 1, 2011
Study Registration Dates
First Submitted
August 6, 2007
First Submitted That Met QC Criteria
August 6, 2007
First Posted (ESTIMATE)
August 8, 2007
Study Record Updates
Last Update Posted (ESTIMATE)
July 22, 2013
Last Update Submitted That Met QC Criteria
July 3, 2013
Last Verified
July 1, 2013
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Eye Diseases
- Corneal Diseases
- Metaplasia
- Neovascularization, Pathologic
- Corneal Neovascularization
- Physiological Effects of Drugs
- Antineoplastic Agents
- Antineoplastic Agents, Immunological
- Angiogenesis Inhibitors
- Angiogenesis Modulating Agents
- Growth Substances
- Growth Inhibitors
- Bevacizumab
Other Study ID Numbers
- WRAMC WU# 07-23022
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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