- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00530998
Minimally Invasive Surgery: Using Natural Orfices (NOTES)
Natural Orifice Translumenal Endoscopic Surgery (NOTES): Laparoscopic Assisted Trans-Vaginal Appendectomy and Cholecystectomy
This is an observational study of pain and outcomes from females undergoing transvaginal NOTES removal of their appendix or gallbladder. Female subjects who elect to have a transvaginal NOTES removal of their appendix or gallbladder and agree to be in this study (through signature on the informed consent form) will be followed per standard of care, with additional follow-up for data collection including the following:
- Subjects will complete a 7 day pain/temperature log after surgery
- Subjects will complete a standardized sexual function questionnaire (Female Sexual Function Index) prior to surgery and 6 months after surgery
- Subjects will receive a phone call at 6 months and at 1 year after surgery to capture data related to safety, adverse events, hospitalizations and patient satisfaction
Additional data related to pain and outcomes will be collected at baseline/screening and at follow-up as necessary.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
California
-
San Diego, California, United States, 92103
- University of California, San Diego
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Group #1: NOTES Appendectomy - Transvaginal approach:
Subjects will be female between the ages of 18-75 who present to the emergency room and are subsequently diagnosed with acute appendicitis. Following diagnosis, investigators will determine if the procedure can be completed via the transvaginal approach. If the patient satisfies the listed criteria then researchers will present study information and offer participation.
Group # 2: NOTES Cholecystectomy - Transvaginal approach:
Female subjects, between the ages of 18-75 who present in the UCSD surgery clinic for elective cholecystectomy will be offered participation in this study.
Description
Inclusion criteria for transvaginal appendectomy:
- Females between the ages of 18-75
- Clinical diagnosis of appendicitis
- Emergency room evaluation within 36 hours of the onset of pain
- ASA Classification 1
- Mentally competent to give informed consent
- Scheduled to undergo a transvaginal NOTES appendectomy.
Exclusion criteria for transvaginal appendectomy:
- Pregnant women (need to have negative icon in ER)
- Morbidly obese patients (BMI >35)
- Patients who are taking immunosuppressive medications or are immunocompromised
- Patients with evidence of an abdominal abscess or mass
- Patients who present with a clinical diagnosis of sepsis or peritonitis
- Patients who have a history of prior transvaginal surgery. Patients with prior laparoscopic surgery will be included.
- Patients who endorse a history of ectopic pregnancy, pelvic inflammatory disease (PID), or severe endometriosis
- Patients with diffuse peritonitis on clinical exam
- Patients on blood thinners or aspirin or abnormal blood coagulation tests
Inclusion criteria for transvaginal cholecystectomy:
- Females between the ages of 18 and 75
- Diagnosis of gallstone disease which requires cholecystectomy
- ASA class 1
- Mentally competent to give informed consent
- Scheduled to undergo a transvaginal NOTES cholecystectomy
Exclusion criteria for transvaginal cholecystectomy:
- Pregnant women
- Morbidly obese patients (BMI > 35)
- Patients who are taking immunosuppressive medications and/or immunocompromised
- Patients with severe medical comorbidities will be excluded.
- Patients with a presumed gallbladder polyps, mass or tumor
- Patients with a history of prior transvaginal surgery. Patients with prior laparoscopic surgery will be included.
- Patients with a history of ectopic pregnancy, pelvic inflammatory disease, or severe endometriosis
- Patients with known common bile duct stones
- Patients on blood thinners or aspirin or abnormal blood coagulation tests
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
1
Group #1 NOTES Appendectomy - Transvaginal approach
|
The appendix will be removed via an incision in the vagina.
|
2
Group #2 NOTES Cholecystectomy - Transvaginal approach
|
The gallbladder will be removed via an incision in the vagina.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
To evaluate the safety and efficacy of transvaginal NOTES appendectomies and cholecystectomies (through data collection).
Time Frame: 1 year
|
1 year
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
To evaluate pain associated with the transvaginal approach (through data collection).
Time Frame: 1 year
|
1 year
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 071115, 140015
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Appendicitis
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-
University of MichiganCompletedAppendicitis | Complicated Appendicitis | Perforated Appendicitis | Ruptured AppendicitisUnited States
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Azienda Socio Sanitaria Territoriale degli Spedali...CompletedAppendicitis | Appendicitis Acute | Appendiceal Abscess | Appendicolith | Appendicitis With Perforation | Appendicitis PeritonitisItaly
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Johns Hopkins All Children's HospitalCompleted
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Pirogov Russian National Research Medical UniversityCompletedAcute Appendicitis | Acute Appendicitis With Rupture | Acute Appendicitis Without Peritonitis | Acute Appendicitis With PeritonitisRussian Federation
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Faculty Hospital Kralovske VinohradyCompletedAppendicitis | Appendicitis Acute | Retrocecal AppendicitisCzechia
-
King Abdulaziz UniversityCompletedAppendicitis | Acute Appendicitis | Pathology | Appendicitis (Diagnosis)Saudi Arabia
-
Mauro PoddaAssociazione Chirurghi Ospedalieri ItalianiCompletedAcute Appendicitis | Appendectomy | Antibiotic Therapy | Appendicitis RecurrentItaly
Clinical Trials on Transvaginal Appendectomy
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Hanoi Medical UniversityCompleted
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Medical Park Gaziantep HospitalMuğla Sıtkı Koçman University; Bahçeşehir UniversityCompletedAcute Appendicitis
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Children's Mercy Hospital Kansas CityCompletedAppendicitisUnited States