Sequenced vs. Integrated Delivery of Treatment for Adolescent Depression and SUD (Sequencing)

March 10, 2014 updated by: Oregon Research Institute

The purpose of this study is to determine whether it is more effective to treat adolescents, with diagnoses of both depression and substance use disorder, with a treatment addressing the substance use first and then treating the depression or to first treat the depression and then treat the substance use or whether treating both disorders simultaneously is most effective.

It is expected that treatment of both disorders at the same time will be the most effective.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Comorbidity is a well established aspect of adolescent psychopathology. The majority of adolescents entering treatment have more than one condition. This study will evaluate service delivery methods of integrating empirically supported interventions for depression and non-nicotine substance use disorders (SUD)in an effort to improve treatment engagement, response, and maintenance of gains. The two examined interventions are the Adolescent Coping With Depression course (ACWD) and Functional Family Therapy (FFT).

This study will expand upon previous research by systematically treating both depression and SUD. Over a 5 year period, 180 adolescents with depression/SUD and their parents/guardians will be recruited in Oregon and New Mexico and randomly assigned to 1 of 3 conditions: (a) FFT followed by ACWD, (b) ACWD followed by FFT, or (c) an intervention combining and augmenting FFT and ACWD (Integrated Treatment). Each treatment arm will consist of 24 sessions provided over 20 weeks. Participants will be assessed at intake, after the provision of 6, 12 (Mid-treatment), 18 and 24 (Post-treatment)treatment sessions, and at 6 and 12 month follow-ups.

Study Type

Interventional

Enrollment (Actual)

180

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Oregon
      • Eugene, Oregon, United States, 97403
        • Oregon Research Institute

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

13 years to 17 years (Child)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  1. DSM-IV-TR diagnosis of depression, defined as MDD, dysthymia, or substance-induced mood disorder meeting MDD or dysthymia symptom criteria
  2. DSM-IV-TR diagnosis of one or more non-nicotine SUD
  3. Some reported illicit drug use in the last 90 days
  4. 13-17 years of age
  5. parent or guardian willing to participate in study
  6. basic English competency (ability to converse in English)

Exclusion Criteria:

  1. Current and acute suicidal ideation at the level warranting inpatient treatment
  2. current psychotic symptoms
  3. the adolescent's sibling is already participating in the study
  4. if on psychiatric medications, a significant change in dosage levels in the prior 4 weeks -

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: TX1
Functional Family Therapy (FFT) followed by Adolescent Coping With Depression (ACWD)
Behavioral: Adolescent Coping With Depression/Functional Family Therapy
ACWD- Cognitive behavioral group therapy for depressed adolescents FFT - Family therapy to address substance use disorders in adolescents
Other Names:
  • FFT
  • ACWD
Experimental: TX 2
ACWD (Adolescent Coping With Depression) followed by FFT (Functional Family Therapy)
Behavioral: Adolescent Coping With Depression/Functional Family Therapy
ACWD- Cognitive behavioral group therapy for depressed adolescents FFT - Family therapy to address substance use disorders in adolescents
Other Names:
  • FFT
  • ACWD
Experimental: TX 3
Combination of an augmented FFT and ACWD - Integrated treatment
Behavioral: Adolescent Coping With Depression/Functional Family Therapy
ACWD- Cognitive behavioral group therapy for depressed adolescents FFT - Family therapy to address substance use disorders in adolescents
Other Names:
  • FFT
  • ACWD

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Children's Depression Rating Scale
Time Frame: Intake, Mid-Treatment, Post, 6 months and 12 months follow-up
Intake, Mid-Treatment, Post, 6 months and 12 months follow-up

Secondary Outcome Measures

Outcome Measure
Time Frame
Time Life Follow Back
Time Frame: Intake, Mid-Treatment, Post, 6 months and 12 months follow-up
Intake, Mid-Treatment, Post, 6 months and 12 months follow-up

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Oregon Research Institute

Investigators

  • Principal Investigator: Paul D Rohde, Ph. D., Oregon Research Institute

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2008

Primary Completion (Actual)

June 1, 2012

Study Completion (Actual)

June 1, 2013

Study Registration Dates

First Submitted

May 16, 2008

First Submitted That Met QC Criteria

May 16, 2008

First Posted (Estimate)

May 20, 2008

Study Record Updates

Last Update Posted (Estimate)

March 12, 2014

Last Update Submitted That Met QC Criteria

March 10, 2014

Last Verified

March 1, 2014

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • DA021357
  • 1R01DA021357 (U.S. NIH Grant/Contract)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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