- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00770107
Thiamine Supplementation to Improve Cardiac Function in Patients With Congestive Heart Failure
June 22, 2011 updated by: Luzerner Kantonsspital
Thiamine Supplementation to Improve Cardiac Function in Patients With Congestive Heart Failure on Long-term Treatment With Diuretic Drugs
Working Hypothesis: a treatment with thiamine improves functional status and heart function of patients with congestive heart failure when on a diuretic treatment.
Study Overview
Detailed Description
In the treatment of congestive heart failure, diuretic drugs have become a firm cornerstone of therapy.
Up to 50% of patients with congestive heart failure in industrialized nations will undergo long-term diuretic treatment.
Diuretic therapy is associated with a loss of water soluble vitamins, including vitamin B1 (thiamine).
Electrolyte dysbalance, a major side effect of diuretic therapy, has been extensively studied.
In sharp contrast, only few data are available about the effects of vitamin loss and in particular of thiamine in this setting.
Available data suggest that a diuretic treatment is associated with an increased risk for thiamine deficiency.
Thiamine plays a crucial role for normal cardiac function, since severe thiamine deficiency leads to congestive heart failure (wet beriberi).
Consequently, patients undergoing diuretic treatment might have compromised heart function.
Supplementation of thiamine has been reported to improve cardiac function in patients with congestive heart failure on long-term treatment with diuretic drugs.
However, no efforts have been made to confirm those preliminary observations by a placebo-controlled, double-blind study.
Study Type
Interventional
Enrollment (Anticipated)
12
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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-
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Luzern, Switzerland, 6000
- Kantonsspital Luzern
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Patients with stable congestive heart failure on a prescription for diuretic drugs
Exclusion Criteria:
- Acute heart failure
- Foreseeable need for further changes in medication
- Current medication containing vitamins
- Patients with a creatinine above 250 μmol/l
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: CROSSOVER
- Masking: QUADRUPLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
PLACEBO_COMPARATOR: Placebo
|
Placebo, once daily, for a duration of 4 weeks
|
ACTIVE_COMPARATOR: Thiamine
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Supplementation of thiamine (vitamin b1) 300 mg per day, once daily, for a duration of 4 weeks
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Left ventricular ejection fraction
Time Frame: One day, one week, two weeks, four weeks
|
One day, one week, two weeks, four weeks
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Quality of life
Time Frame: One day, one week, two week, four weeks
|
One day, one week, two week, four weeks
|
6-minutes walking test
Time Frame: One day, one week, two weeks, four weeks
|
One day, one week, two weeks, four weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
June 1, 2004
Primary Completion (ACTUAL)
December 1, 2009
Study Completion (ACTUAL)
December 1, 2009
Study Registration Dates
First Submitted
October 3, 2008
First Submitted That Met QC Criteria
October 8, 2008
First Posted (ESTIMATE)
October 9, 2008
Study Record Updates
Last Update Posted (ESTIMATE)
June 27, 2011
Last Update Submitted That Met QC Criteria
June 22, 2011
Last Verified
June 1, 2011
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Thiamine in Heart Failure
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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