- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00830401
The Impact of Treating Minor Uterine Cavity Abnormalities Diagnosed by Office Hysteroscopy in Unselected In Vitro Fertilization (IVF) Cases
Comparative Controlled Trial of Treatment of Minor Unexpected Uterine Cavity Abnormalities Diagnosed by Office Hysteroscopy Screening in Women Indicated for IVF
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Introduction- Implantation failure after IVF may be due to endometrial function, embryo quality or a combination of both. The prevalence of minor intracavitary pathology in cases with an apparent normal transvaginal sonography (TVS) observed at hysteroscopy has been recorded to be 25-40%. Treatment of such pathology prior to initiating IVF/ICSI has been advocated without high-quality evidence.
Objective- To evaluate the impact of treating undetected, asymptomatic, predefined minor uterine cavity abnormalities on the success of IVF treatment.
Material & methods- Patients, indicated for their first IVF/ICSI treatment cycle at the UMC Utrecht and AZ-VUB Brussels, initially underwent TVS. In case of a normal TVS these patients were scheduled for hysteroscopy in the early-mid follicular phase of the cycle, one to three months before starting IVF/ICSI treatment. Vaginoscopic hysteroscopy was performed in an ambulatory office setting. During the hysteroscopy a biopsy was taken, to diagnose chronic endometrial inflammation. In case of finding a predefined intra uterine abnormality (polyp, myoma, adhesion, septum, endometrial inflammation) randomisation took place if prior to hysteroscopy informed consent had been obtained for endoscopy treatment versus no treatment. Shortly after the hysteroscopy, IVF/ICSI treatment was initiated and outcome during one year treatment period will be recorded.
Study Type
Enrollment (Actual)
Phase
- Phase 2
Contacts and Locations
Study Locations
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-
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Utrecht, Netherlands, 3500VW
- UMC Utrecht
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Normal Transvaginal Ultrasound
- No prior hysteroscopy
- Regular menstrual cycle
- Single embryo transfer
- BMI between 18 and 29
- Presence of both ovaries
- Primary or secondary infertility
- Women indicated for a first IVF/ICSI cycle
Exclusion Criteria:
- Recurrent miscarriage
- Prior hysteroscopic treatments
- Endometriosis > AFS Stage II
- Meno-metrorrhagia (defined as any intermenstrual loss of blood)
- Submucosal/Intracavitary Fibroids taking more than 50% of the cavity
- Hydrosalpinx
- FSH/LH > 12IU/L on day 3
- Polyps taking more than 50% of the cavity
- Severe adhesions > grade II
Study Plan
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
NO_INTERVENTION: 1
One or more of the predefined minor intra-uterine abnormalities have been detected, but not treated during hysteroscopy.
|
|
ACTIVE_COMPARATOR: 2
One or more of the predefined minor intra-uterine abnormalities have been detected and treated during hysteroscopy.
|
Treatment of endometrial inflammation: Ofloxacinum 400mg/day or Doxycyline 2x100mg on day one, followed by 100mg/day during 8 days.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Cumulative implantation rate
Time Frame: One year
|
One year
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Cumulative ongoing pregnancy
Time Frame: One year
|
One year
|
Presence of minor uterine abnormalities
Time Frame: At hysteroscopy
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At hysteroscopy
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Study Chair: Bart CJM Fauser, Prof. dr., UMC Utrecht
- Study Chair: Paul Devroey, Prof. dr., AZ-VUB
- Study Director: Frank JM Broekmans, Dr., UMC Utrecht
- Study Director: Human M Fatemi, Dr., AZ-VUB
- Principal Investigator: Jenneke C Kasius, UMC Utrecht
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ESTIMATE)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- TEAtrial
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