- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00939393
Balloon Sinus Dilation In Office or OR (ORIOS)
September 21, 2017 updated by: Acclarent
ESS Performed in Operating Room Versus Clinician's Office
Endoscopic sinus surgery will be performed either in the physician's office or in the operating room (OR).
Patients treated in the physician's office will have endoscopic sinus surgery performed with balloon sinuplasty devices.
Patients treated in the OR will have endoscopic sinus surgery performed with or without balloon sinuplasty devices.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
In this study, endoscopic sinus surgery will be performed either in the physician's office or in the operating room (OR).
Patients treated in the physician's office will have endoscopic sinus surgery performed with the balloon sinuplasty devices.
Patients treated in the OR will have endoscopic sinus surgery performed with or without balloon sinuplasty devices.
Both primary treatment of sinusitis as well as revision of previously treated sinuses will be allowed.
Resource absorption will be evaluated for both venues.
Study Type
Interventional
Enrollment (Actual)
72
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Ohio
-
Independence, Ohio, United States, 44131
- Rockside Road Surgery Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Age 18 years and greater
- Both male and female patients eligible
- Diagnosis of chronic sinusitis that is not responsive to medical management (> 12 weeks of symptoms and failed at least 3 to 6 weeks of appropriate antibiotic therapy as evidenced by presence of disease on CT scan)
- Planned endoscopic sinus surgery (recommended by investigator, consented to by patient)
Exclusion Criteria:
- Cystic fibrosis
- Samter's Triad (Aspirin sensitivity, Asthma, Sinonasal polyposis)
- Sinonasal tumors or obstructive lesions
- History of facial trauma that distorts sinus anatomy and precludes access to the sinus ostium
- Ciliary dysfunction
- Pregnant females
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Health Services Research
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: FESS in OR with or without balloons
Functional Endoscopy Sinus Surgery
|
Intervention with metal instruments with or without balloon treatment
|
Active Comparator: Balloon sinuplasty in physician office
Balloon Sinuplasty in physician office using Acclarent devices
|
Balloon dilatation of sinuses
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Mean Intra-patient Change in SNOT-20 Score at 24 Weeks Post-procedure Compared to Baseline
Time Frame: 24 weeks
|
The 20 question Sino-Nasal Outcome Test (SNOT-20) will be used to evaluate sinus symptoms and sinus-symptom related quality of life (QOL) at baseline, 1 week, 4 weeks, 24 weeks and 52 weeks post-procedure.
The change in SNOT-20 score at each post-procedure time point will be evaluated compared to baseline SNOT-20 score.
Each of the 20 questions in the SNOT-20 survey is scored on a scale of 0 to 5, where '0' represents 'no problem' and '5' represents 'problem as bad as it can be'.
The 20 questions are expressed as a mean of the scores.
Therefore, the minimum mean score is zero and the maximum mean score is 5.
|
24 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Mean Intra-patient Change in Lund-MacKay CT Score [24 Weeks]
Time Frame: 24 weeks
|
The Lund-MacKay (LMK) CT (computed tomography) score is a scoring system to evaluate radiographic opacification of the paranasal sinuses.
The LMK score will be evaluated at 24 weeks post-procedure compared to baseline.
The LMK scoring system rates each of both the left and right frontal, maxillary, sphenoid, ostiomeatal complex, anterior ethmoid and posterior ethmoid sinuses on a scale of 0 to 2, where '0' is 'no opacification' and '2' is 'complete opacification'.
The scores for a given subject are totaled and expressed as the LMK score, where zero is the minimum score, and 24 is the maximum score.
A higher score represents greater sinus disease burden.
|
24 weeks
|
Proportion of Participants Rating Procedure as Tolerable (IO Only)
Time Frame: Day 0
|
Participants evaluated the tolerability of their balloon dilation in office (IO = In Office) procedure on a scale from zero to 5, where '0' represented 'not tolerated' and '5' represented 'highly tolerable'.
Scores of 3 through 5 were consdered tolerable ratings.
The endpoint reports the proportion of participants rating the procedure as tolerable.
|
Day 0
|
Proportion of Participants Reporting No Pain or Pain of Low Intensity (IO Only)
Time Frame: Day 0
|
Participants evaluated the per-procedural pain of their balloon dilation in office (IO = In Office) procedure on a scale from zero to 5, where '0' represented 'no pain' and '5' represented 'intense pain'.
Scores of 0 through 2 were considered ratings of no pain or pain of low intensity.
The endpoint reports the proportion of participants reporting no pain or pain of low intensity.
|
Day 0
|
Mean Number of Debridements Per Participant (IO Only)
Time Frame: 52 weeks
|
A debridement is a procedure to remove post-surgical crusts, mucus, and fibrin from obstructed nasal and sinus cavities after functional endoscopic sinus surgery.
Each physician visit in which a debridement was performed was counted as one debridement.
|
52 weeks
|
Proportion of Participants With Revisions (IO Only)
Time Frame: 52 weeks
|
After sinus surgery, the patient may require a subsequent sinus procedure (a revision procedure) to address recurrence of disease.
These revision procedures are assessed in this outcome measure.
|
52 weeks
|
Proportion of Participants With Post-operative Sinus Infections
Time Frame: 52 weeks
|
Investigators reported the sinus infections as secondary to chronic rhinosinusitis (CRS) or other pre-existing conditions such as allergies.
The rates of these sinus infections are consistent with the disease burden of the subjects and consistent with post procedure symptomatology associated with endoscopic sinus surgery (ESS).
|
52 weeks
|
Mean Intra-patient Change in SNOT-20 Score at 1 Week Post-procedure Compared to Baseline
Time Frame: 1 week
|
The 20 question Sino-Nasal Outcome Test (SNOT-20) will be used to evaluate sinus symptoms and sinus-symptom related quality of life (QOL) at baseline, 1 week, 4 weeks, 24 weeks and 52 weeks post-procedure.
The change in SNOT-20 score at each post-procedure time point will be evaluated compared to baseline SNOT-20 score.
Each of the 20 questions in the SNOT-20 survey is scored on a scale of 0 to 5, where '0' represents 'no problem' and '5' represents 'problem as bad as it can be'.
The 20 questions are expressed as a mean of the scores.
Therefore, the minimum mean score is zero and the maximum mean score is 5.
|
1 week
|
Mean Intra-patient Change in SNOT-20 Score at 4 Weeks Post-procedure Compared to Baseline
Time Frame: 4 weeks
|
The 20 question Sino-Nasal Outcome Test (SNOT-20) will be used to evaluate sinus symptoms and sinus-symptom related quality of life (QOL) at baseline, 1 week, 4 weeks, 24 weeks and 52 weeks post-procedure.
The change in SNOT-20 score at each post-procedure time point will be evaluated compared to baseline SNOT-20 score.
Each of the 20 questions in the SNOT-20 survey is scored on a scale of 0 to 5, where '0' represents 'no problem' and '5' represents 'problem as bad as it can be'.
The 20 questions are expressed as a mean of the scores.
Therefore, the minimum mean score is zero and the maximum mean score is 5.
|
4 weeks
|
Mean Intra-patient Change in SNOT-20 Score at 52 Weeks Post-procedure Compared to Baseline
Time Frame: 52 weeks
|
The 20 question Sino-Nasal Outcome Test (SNOT-20) will be used to evaluate sinus symptoms and sinus-symptom related quality of life (QOL) at baseline, 1 week, 4 weeks, 24 weeks and 52 weeks post-procedure.
The change in SNOT-20 score at each post-procedure time point will be evaluated compared to baseline SNOT-20 score.
Each of the 20 questions in the SNOT-20 survey is scored on a scale of 0 to 5, where '0' represents 'no problem' and '5' represents 'problem as bad as it can be'.
The 20 questions are expressed as a mean of the scores.
Therefore, the minimum mean score is zero and the maximum mean score is 5.
|
52 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Howard Levine, MD, Rockside Road Surgery Center Independence, OH
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
April 1, 2008
Primary Completion (Actual)
June 1, 2009
Study Completion (Actual)
July 1, 2010
Study Registration Dates
First Submitted
July 14, 2009
First Submitted That Met QC Criteria
July 14, 2009
First Posted (Estimate)
July 15, 2009
Study Record Updates
Last Update Posted (Actual)
October 23, 2017
Last Update Submitted That Met QC Criteria
September 21, 2017
Last Verified
September 1, 2017
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- CPR005002
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
Yes
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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