- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01045785
Investigation of Platelet Function and Aspirin Resistance in Chronic Dialysis Patient
January 8, 2010 updated by: National Taiwan University Hospital
The purpose of this study is to determine whether aspirin resistance has impact on cardiovascular event in dialysis patient.
Study Overview
Status
Unknown
Conditions
Detailed Description
Dialysis patient inevitably suffered from uremic bleeding although improvement of dialysis care in the past decades.
Physicians used to check bleeding time as a surrogate marker for uremic bleeding.
However, bleeding time isn't accurate and as well known, is poorly correlated with clinical bleeding such as surgical bleeding.
Platelet function assay (PFA) is a newly developed method to measure platelet aggregation in vitro and is validated in many sorts of platelet disorders.
Recently, PFA was also used to evaluate aspirin responsiveness in patients who had taken aspirin.
Our study is aim to investigate uremic thrombocytopathy via PFA of dialysis patient in Taiwan.
Furthermore, we will study aspirin resistance in dialysis patient.
Study Type
Observational
Enrollment (Anticipated)
300
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Taipei, Taiwan, 100
- National Taiwan University Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Dialysis patients which follow-up at least monthly at National Taiwan University Hospital
Description
Inclusion Criteria:
- dialysis >3 months
- Hb>10 g/dl & Plt > 10000
Exclusion Criteria:
- using medication which interfere PFA except aspirin
- terminal disease such as malignancy
- active vasculitis
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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aspirin responsive
PFA Col/EPI normal
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aspirin resistance
PFA Col/epi showed resistance
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
cardiovascular event, bleeding event,and thrombosis
Time Frame: 1 year
|
1 year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Jenqwen Huang, MD, National Taiwan University Hospital
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
Helpful Links
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
December 1, 2009
Primary Completion (Anticipated)
June 1, 2010
Study Completion (Anticipated)
July 1, 2010
Study Registration Dates
First Submitted
January 8, 2010
First Submitted That Met QC Criteria
January 8, 2010
First Posted (Estimate)
January 11, 2010
Study Record Updates
Last Update Posted (Estimate)
January 11, 2010
Last Update Submitted That Met QC Criteria
January 8, 2010
Last Verified
December 1, 2009
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 200912018R
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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