- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01166451
The Anemia Control Program: High or Low Iron Supplementation
October 17, 2011 updated by: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Iron Deficiency Anemia and Infant Behavior: Preventive Trial
The purpose of this clinical trial was to determine if high-iron or low-iron formula, containing an average of 12.7 mg/L or 2.3 mg/L respectively, had differing effects on iron status in infancy and on development longitudinally.
Study Overview
Status
Completed
Intervention / Treatment
Detailed Description
For a detailed description of the clinical trial setting and procedures in infancy, please refer to the following:
Walter T, Pino P, Pizarro F and Lozoff B. Prevention of iron-deficiency anemia: Comparison of high- and low-iron formulas in term healthy infants after six months of life. J Pedr 1998:132:635-40.
Study Type
Interventional
Enrollment (Actual)
835
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Santiago, Chile
- Instituto de Nutriticion y Tecnologia de los Alimentos
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
6 months to 6 months (Child)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Birth weight >= 3.0 kg
- single birth
- no major congenital anomalies
- no major birth or neonatal complications
- no emergency c-section
- no jaundice requiring phototherapy
- no hospitalization for more than 5 days
- no chronic illness
- no iron therapy
- already started to received some bottle feedings by 6 months of age
Exclusion Criteria:
- residence outside identified neighborhoods
- another infant <12 months in household
- infant in daycare
- unstable, illiterate, or psychotic caregiver
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Low-iron
Infants randomly assigned at 6 months of age to receive low-iron formula (average 2.3 mg/L, range 1.6 - 2.4 mg/L) until 12 months of age.
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Infants randomly assigned at 6 months of age to receive low-iron formula (average 2.3 mg/L, range 1.6 - 2.4 mg/L) until 12 months of age.
Low-iron formula distributed in powdered form.
Project personnel visited infants' homes weekly to record measures of powdered formula used per day.
Formula consumption was also verified by the number of cans given by the clinic nurse at each visit (regular pediatric visits and monthly clinic appointments until 12 months of age.)
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Experimental: High-iron
Infants randomly assigned at 6 months of age to receive high-iron formula (average 12.7 mg/L) until 12 months of age.
|
Infants randomly assigned at 6 months of age to receive high-iron formula (average 12.7 mg/L) until 12 months of age.
High-iron formula distributed in powdered form.
Project personnel visited infants' homes weekly to record measures of powdered formula used per day.
Formula consumption was also verified by the number of cans given by the clinic nurse at each visit (regular pediatric visits and monthly clinic appointments until 12 months of age.)
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
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Iron deficiency anemia
Time Frame: 12 and 18 months
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12 and 18 months
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Secondary Outcome Measures
Outcome Measure |
Time Frame |
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Longitudinal child behavior and development
Time Frame: 10 years
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10 years
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Betsy Lozoff, MD, University of Michigan
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Walter T, Pino P, Pizarro F, Lozoff B. Prevention of iron-deficiency anemia: comparison of high- and low-iron formulas in term healthy infants after six months of life. J Pediatr. 1998 Apr;132(4):635-40. doi: 10.1016/s0022-3476(98)70352-x.
- East PL, Reid B, Blanco E, Burrows R, Lozoff B, Gahagan S. Iron supplementation given to nonanemic infants: neurocognitive functioning at 16 years. Nutr Neurosci. 2023 Jan;26(1):40-49. doi: 10.1080/1028415X.2021.2013399. Epub 2021 Dec 19.
- East P, Doom J, Blanco E, Burrows R, Lozoff B, Gahagan S. Young adult outcomes associated with lower cognitive functioning in childhood related to iron-fortified formula in infancy. Nutr Neurosci. 2022 Apr;25(4):709-718. doi: 10.1080/1028415X.2020.1804099. Epub 2020 Aug 11.
- Gahagan S, Delker E, Blanco E, Burrows R, Lozoff B. Randomized Controlled Trial of Iron-Fortified versus Low-Iron Infant Formula: Developmental Outcomes at 16 Years. J Pediatr. 2019 Sep;212:124-130.e1. doi: 10.1016/j.jpeds.2019.05.030. Epub 2019 Jun 26.
- Lozoff B, Castillo M, Clark KM, Smith JB. Iron-fortified vs low-iron infant formula: developmental outcome at 10 years. Arch Pediatr Adolesc Med. 2012 Mar;166(3):208-15. doi: 10.1001/archpediatrics.2011.197. Epub 2011 Nov 7.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
September 1, 1991
Primary Completion (Actual)
August 1, 1994
Study Completion (Actual)
March 1, 2004
Study Registration Dates
First Submitted
July 19, 2010
First Submitted That Met QC Criteria
July 19, 2010
First Posted (Estimate)
July 21, 2010
Study Record Updates
Last Update Posted (Estimate)
October 18, 2011
Last Update Submitted That Met QC Criteria
October 17, 2011
Last Verified
October 1, 2011
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- R01HD033487 (U.S. NIH Grant/Contract)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Iron Deficiency Anemia
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Pennington Biomedical Research CenterRecruitingIron-deficiency | Iron Deficiency Anemia | Iron Deficiency Anemia TreatmentUnited States
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Children's Hospital Los AngelesNot yet recruitingAnemia | Iron Deficiency Anemia | Anemia, Iron Deficiency | IDA - Iron Deficiency AnemiaUnited States
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King's CollegeCompletedIron-deficiency | Iron Deficiency Anemia | Iron Deficiency (Without Anemia)United States
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Arrowhead Regional Medical CenterRecruitingIron Deficiency Anemia of PregnancyUnited States
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Swiss Federal Institute of TechnologyUnited States Agency for International Development (USAID); Quadram Institute... and other collaboratorsCompletedIron-deficiency | Iron Deficiency Anemia | Iron Deficiency (Without Anemia)Peru
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Luzerner KantonsspitalRecruitingIron Deficiency Anemia | Iron Deficiency Anemia Treatment | Iron DeficienciesSwitzerland
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Children's Hospital Los AngelesWithdrawnAnemia | Iron-deficiency Anemia | Healthy ControlsUnited States
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Baylor College of MedicineNational Heart, Lung, and Blood Institute (NHLBI)CompletedIron-deficiency | Iron Deficiency AnemiaUnited States
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Iowa State UniversityCompletedIron-deficiency | Iron Deficiency Anemia | Iron Deficiency Anemia Treatment | Iron Deficiency Anaemia Due to Dietary CausesUnited States
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Société des Produits Nestlé (SPN)CompletedIron-deficiency | Anemia | Iron Deficiency AnemiaPhilippines
Clinical Trials on Low-iron formula
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Umeå UniversityUniversity of California; Mead Johnson NutritionActive, not recruitingHealth of Formula-fed Children | Infant Infections in Formula-fed Children | Iron Status of Formula-fed ChildrenSweden
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Fondazione IRCCS Ca' Granda, Ospedale Maggiore...Humana Co.Ltd.CompletedSafety Issues | Infant Nutrition DisordersItaly
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Umeå UniversityUniversity of California, Davis; Swiss Federal Institute of TechnologyCompletedInfant | Dietary Supplements | Food, FortifiedSweden
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Children's Hospital of Fudan UniversityCompleted
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Société des Produits Nestlé (SPN)Completed
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Perrigo NutritionalsCompletedGrowth | Healthy Term InfantsUnited States
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University of Colorado, DenverRecruiting
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University Rovira i VirgiliCompletedNeurodevelopmental Disorders | Lactation
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MetroHealth Medical CenterCompletedNeonatal Abstinence SyndromeUnited States
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University of CologneCompletedChronic Kidney DiseaseGermany