Study TO Prevent Diabetes With Short-term Insulin Glargine Only (STOP-GO)

A Multicenter, Randomized, Controlled Trial to Prevent Diabetes With Short-term Insulin Glargine Treatment or Lifestyle Intervention

• Pre-diabetes is a significant risk factor for the development of type 2 diabetes, as well as macrovascular and microvascular complication.
• Previous studies show that 50% or more loss in islet B-cell function even in Pre-diabetes phase. The early insulin therapy in pre-diabetes may be a strategy in preventing metabolic disorders and cardiovascular disease.
• The objective of this study is to find if an initial insulin glargine intervention in pre-diabetes (IGT and /or IFG) could be a strategy in preventing type 2 Diabetes.
• Pre-diabetes subjects will receive a insulin glargine therapy with a dosage adjusted to get FBG ≤ 5.3mmol / L as the goal. Insulin glargine treatment will be maintained for three months thereafter to find if it can prevent diabetes.

Study Overview

• Status: Unknown
• Conditions: Pre-diabetes
• Intervention / Treatment: Drug: Insulin glargine; Behavioral: Lifestyle counseling

• Study Type: Interventional
• Enrollment (Anticipated): 2420
• Phase: Not Applicable

Contacts and Locations

Study Locations

• China
  • Beijing, China, 100730
    • Recruiting
    • Beijing Tongren Hospital
    • Contact: Jin-Kui Yang, M.D., Ph.D.; Phone Number: +86-10-58268445; Email: jinkui.yang@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 25 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

1. All participants are voluntary and write informed consent 2 weeks before enrollment.
2. Fasting Blood Glucose between >= 5.6mmol/L and <7.0mmol/L, and HbA1c between >= 5.7% and <6.5%.
3. Both male and female aged between >= 25 and ≤ 65 years.
4. Participants have the ability to use self-monitoring devices to measure their blood glucose level and practice self-insulin injection.
5. Have the ability and willingness to complete the study logs and questionnaires.
6. Pregnancy test of all child-bearing age women should be negative, and they agree to adopt contraceptive measures in the study process.

Exclusion Criteria:

1. With previous diagnosis of diabetes or application of hypoglycemic drugs.
2. Preliminary screen for fasting plasma glucose lever ≥7.0mmol/L or <5.6mmol/L.
3. Preliminary screen for HbA1c result HbA1c<5.7% or ≥ 6.5%.
4. Receiving cancer treatment in the past 5 years.
5. Preliminary diagnostic anti-HIV test result positive, with no serological testing.
6. People with active tuberculosis.
7. Persons hospitalized for heart disease and received the treatment measures (such as coronary artery bypass graft CABG, percutaneous transluminal coronary angioplasty PTCA), while not include diagnostic measures (such as percutaneous coronary angiography) in the past 6 months.
8. Cardiac function evaluated by New York Heart Association criteria (NYHA) ≥ 3 cardiac function level
9. Uncontrolled high blood pressure - systolic blood pressure > 180mmHg or diastolic blood pressure > 105mmHg after treatment.
10. Stroke or transient ischemic attack episode in the past 6 months.
11. With chronic hepatitis or active liver disease, or serum AST or ALT 2.5 times the upper limit of normal.
12. Male serum creatinine ≥ 124μmol/L (1.4mg/dL); Female serum creatinine ≥ 115μmol/L (1.3mg/dL).
13. Systemic glucocorticoids applications, but other than local, eye, and inhalation applications.
14. Anemia: male hematocrit <36.0%; female <33.0%.
15. Other chronic diseases which may lead to the expected life less than 6 years or conditions that may affect life expectancy.
16. Mental disorder history.
17. Alcohol consumption (average 50g or more high spirits drink or 100g or more low spirits drink) or drug abuse.
18. Unable or unwilling to sign informed consent.
19. Cannot communicate or contact with the clinical staff.
20. Unwilling to receive insulin injection therapy or conduct self-monitoring of blood glucose.
21. Unsatisfied control of thyroid disease - subjects who are suffering thyroid disease or receiving anti-thyroid drugs or thyroid hormone treatment, show the sensitive TSH abnormalities (except for patients with low TSH who have the history of thyroid tumor or thyroid cancer receiving the inhibitor treatment).
22. Any other factors that may affect compliance or adverse events reported during the research program.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
HbA1c >= 6.5%	Two years

Secondary Outcome Measures

Outcome Measure	Time Frame
FPG >= 7.0 for two times in a month.	Two years
HbA1c >= 7.0%	Two years

Collaborators and Investigators

• Sponsor: Beijing Tongren Hospital

Study record dates

Study Major Dates

• Study Start: January 1, 2011
• Primary Completion (Anticipated): October 1, 2013
• Study Completion (Anticipated): December 1, 2013

Study Registration Dates

• First Submitted: January 13, 2011
• First Submitted That Met QC Criteria: January 13, 2011
• First Posted (Estimate): January 14, 2011

Study Record Updates

• Last Update Posted (Estimate): January 14, 2011
• Last Update Submitted That Met QC Criteria: January 13, 2011
• Last Verified: January 1, 2011

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases; Diabetes Mellitus; Prediabetic State; Hypoglycemic Agents; Physiological Effects of Drugs; Insulin Glargine
• Other Study ID Numbers: STOP-GO-2010