Orange Juice Consumption and Cognitive Function

Effect of Chronic Orange Juice Consumption on Cognitive Function in Healthy Older Adults

Sponsors

Lead Sponsor: University of Reading

Source University of Reading
Brief Summary

This study is investigating the effect of 8 weeks of orange juice supplementation on executive function in healthy older adults. The study is a controled, double-blind, crossover trial and involves a 8 week supplementation with a high flavonone orange juice and a carbohydrate-matched control. Volunteers consume 500ml of either the test juice or the control juice per day for an 8 week period. There is then an 8 week washout period before subjects proceed to the other arm of the study. Subjects are randomly assigned to either arm at the beginning of the study. Measures of cognitive function will be administered pre and post both test and control interventions. Blood pressure will also be measured and blood and urine samples will be collected to assess absorption of from the juice. A sub-sample of volunteers will undergo MRI imaging pre- and post intervention to acquire cerebral blow flow information.

Overall Status Completed
Start Date September 2010
Completion Date September 2011
Primary Completion Date August 2011
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
Executive function - Attention change in attention from baseline and 8 weeks
Secondary Outcome
Measure Time Frame
Plasma flavanones change from baseline to 8 weeks
Blood pressure change from baseline to 8 weeks
Enrollment 40
Condition
Intervention

Intervention Type: Dietary Supplement

Intervention Name: High flavanone orange juice

Description: High flavonone orange juice drink.

Arm Group Label: High flavonone orange juice drink

Other Name: Frozen Orange Juice; Department of Citrus, Florida, USA.

Intervention Type: Dietary Supplement

Intervention Name: Control orange juice

Description: Orange beverage, low flavanone content, matched for total carbohydrate content, individual sugar profile, vitamin C

Arm Group Label: Control orange juice drink

Eligibility

Criteria:

Inclusion Criteria:

- In good general health i.e. no major health condition such as diabetes

- BMI < 30

- Cholesterol < 6 and BP < 150/90

- Not on blood pressure medication or blood thinning medication such as aspirin - No learning difficulty such as dyslexia

Exclusion Criteria:

- Diabetes

- Gastro-intestinal disease

- High BMI

- Cholesterol and BP

- Smoker

- On blood pressure medication or blood thinning medication such as aspirin

- Dyslexic/dyspraxic

- Depression or history of depression

Gender: All

Minimum Age: 60 Years

Maximum Age: 75 Years

Healthy Volunteers: Accepts Healthy Volunteers

Overall Official
Location
Facility: University of Reading
Location Countries

United Kingdom

Verification Date

November 2011

Responsible Party

Type: Principal Investigator

Investigator Affiliation: University of Reading

Investigator Full Name: Jeremy Paul Edward Spencer

Investigator Title: Professor Jeremy Spencer

Keywords
Has Expanded Access No
Condition Browse
Number Of Arms 2
Arm Group

Label: High flavonone orange juice drink

Type: Experimental

Label: Control orange juice drink

Type: Placebo Comparator

Description: Juice drink matched for sugar content

Acronym OJOC
Study Design Info

Allocation: Randomized

Intervention Model: Crossover Assignment

Primary Purpose: Basic Science

Masking: Single (Participant)

Source: ClinicalTrials.gov