Prevalence of Dissociative Disorders in Children

Prevalence of Dissociative Disorders in Children in a Population Supported in the Medico-social and Health Structures in Provence Alpes Cote d'Azur

Schizophrenia beginning before 18 years is a clinical entity not well known because of its low incidence and difficulties in the clinical diagnosis.

However, in the investigators clinical practice, due to the specialization of the investigators service, the investigators are led to hospital to receive important feel active of patients meeting the Diagnostic and Statistical Manual of Mental Disorders IV text revision (DSM IV-TR) precose schizophrenia.

The work of us team on the theme of the relationship between Pervasive Developmental Disorders and precose Schizophrenia led us to hypothesize that a number of children in care in the medical and educational institutes, hospitals and day shelters therapeutic part-time symptoms of schizophrenia or a line real early diagnosis of schizophrenia undervalued or not diagnosed.

The main goal is to estimate the prevalence of dissociative disorders in a population of children in care institutions and medical education in child psychiatry in hospitals and others structures.

Study Overview

• Status: Completed
• Conditions: Schizophrenia; Dissociative Disorders
• Intervention / Treatment: Other: Primary stage; Other: Secondary stage

• Study Type: Interventional
• Enrollment (Actual): 301
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Antibes, France, 06600
    • Psychiatrie infanto-juvénile - Centre Hospitalier d'Antibes
  • Fréjus, France, 83608
    • Psychiatrie infanto-juvénile-Pôle femme-mère -enfant
  • Marseille, France, 13009
    • Service de psychiatrie de l'enfant et de l'adolescent
  • Nice, France, 06000
    • Service de psychiatrie de l'enfant et de l'adolescent

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 3 years to 14 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• 7 to 18 years
• Supported in the partner institutions of the study
• IQ>35 on the certificate of orientation of the Maison Départementale des Personnes Handicapées (MDPH)
• Obtaining the agreement of parents and children

Exclusion Criteria:

• QI<35 on the certificate file Guidance MDPH
• Children not speaking french

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Diagnostic
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Children with Dissociative Disorders; Children will take first the primary stage. If one child is positive, he will pass the secondary stage.	Other: Primary stage; Kiddie-Schedule for Affective Disorders and Schizophrenia; Other: Secondary stage; children who are positive to the kiddie-SADS (primary stage), will take the tests: PANSS, Scale for the Assessment of Negative Symptoms (SANS), ADI-R, scale TLC and WISC IV

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Rate of children diagnosed with dissociative disorders	Rate of children diagnosed with dissociative disorders: children positive for the test Kiddie-Schedule for Affective Disorders and Schizophrenia (Kiddie-SADS).	between 2 and 4 hours depending children

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Percentage of children positive for test: Autism Diagnostic Interview-Revise (ADI-R).		1 day on average
Scores of three dimensions of schizophrenia in the Positive And Negative Syndrome Scale (PANSS)	3 dimensions: positive symptoms, negative symptoms and general psychopathology, based on these scores the diagnostic subtype of schizophrenia is established.	4 hours
Score at the Test Lillois de Communication (TLC)		30 minutes
Score on the Wechsler Intelligence Scale for Children-Fourth Edition (WISC IV)subtests and overall intelligence quotient (IQ).		4 hours
Response time to test verbal fluency, scores on the Trail Making Test A (TMT) and TMT B.		30 minutes

Collaborators and Investigators

• Sponsor: Centre Hospitalier Universitaire de Nice
• Investigators: Study Director: Florence ASKENAZY, PU-PH, University Hospital of Nice; Principal Investigator: Emmanuelle DOR, PH, University Hospital of Nice; Principal Investigator: François POINSO, PU-PH, AP-HM; Principal Investigator: Michèle BATTISTA, PH, Frejus's hospital; Principal Investigator: Michel BOUBLIL, PH, Antibes's hospital

Publications and helpful links

General Publications

• Dor-Nedonsel E, Menard ML, Fernandez A, Sakarovitch C, Fontas E, Salle-Collemiche X, Poinso F, Tosello AL, Maria F, Manera V, Askenazy F, Thummler S. Early-Onset Schizophrenia in a paediatric population of French psychiatric and medico-social care centres: A cross sectional study. PLoS One. 2020 Jul 27;15(7):e0236241. doi: 10.1371/journal.pone.0236241. eCollection 2020.

Study record dates

Study Major Dates

• Study Start: December 1, 2011
• Primary Completion (Actual): May 1, 2013
• Study Completion (Actual): May 1, 2013

Study Registration Dates

• First Submitted: December 13, 2011
• First Submitted That Met QC Criteria: January 18, 2012
• First Posted (Estimate): January 19, 2012

Study Record Updates

• Last Update Posted (Estimate): February 3, 2014
• Last Update Submitted That Met QC Criteria: January 31, 2014
• Last Verified: January 1, 2014

More Information

Terms related to this study

• Keywords: children dissociative disorders schizophrenia
• Additional Relevant MeSH Terms: Mental Disorders; Pathologic Processes; Schizophrenia Spectrum and Other Psychotic Disorders; Somatoform Disorders; Schizophrenia; Disease; Dissociative Disorders; Conversion Disorder
• Other Study ID Numbers: 11-API-01