- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01603017
Nuclear Magnetic Resonance Therapy in Knee Osteoarthrosis
Nuclear Magnetic Resonance Therapy in Knee Osteoarthrosis: A Double Blind Ranomised Controlled Trial
Nuclear Magnetic Resonance Therapy (NMRT) is gaining as a novel mode of therapy in osteoarthrosis. A prospective double blind randomised study of 100 patients was conducted to investigate efficacy of NMRT in the treatment of mild to moderate osteoarthrosis (OA) of the knee joint.
The null hypothesis was that there is no benefit of NMRT over placebo in mild to moderate oteoarthosis of the knee.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
This study was approved by the Regional Ethics Committee. Patients were recruited from referrals made by General Practitioners to a single Orthopaedic Outpatient Department between October 2007 and February 2008. The study was a prospective placebo controlled, double blind randomised mono centric study with a follow up period of 6 months.
All potential trial participants demonstrated symptomatic mild to moderate OA of the knee joint diagnosed by an experienced consultant orthopaedic surgeon. Radiographic evidence was gathered by means of standard clinical standing antero-posterior and lateral radiographs of the knee.
Baseline assessment included :
- clinical examination
- active Range of movement
- plain radiographs
- WOMAC osteoarthritis index
- Oxford Knee Score (OKS)
- Severity of pain VAS.
- Strength and frequency of any painkillers taken.
- Phyasiotherapy Study design was directed at use of NMRT in a clinical setting. It was therefore considered valid to not restrict the use of the pain killers and physiotherapy. Positional Magnetic Resonance Imaging (pMRI) scan of the knee joint was undertaken.
Randomisation was carried out by means of visually identical computer chip cards numbered from 1 to 100 which had been independently programmed by the manufacturer. Thus, half of the computer chip cards (n=50) were programmed to activate the magnetic fields (= treatment group) and remaining half (n=50) were programmed not to activate magnetic fields (=placebo group) of the device. The research team and patients were blinded to the programmed activity of the cards. The magnetic resonance indicator LED lamp on the device was disabled by the manufacturer to ensure that the operator and patients were blinded to the therapy status. Every patient entering the study was asked to choose a numbered card from those available, and this card was then used to operate the device for that specific patient for all five sessions of NMRT.
The study used the manufacturer's clinical recommendation for therapy. Patients were subjected to one-hour sessions of NMRT (or placebo) on five consecutive days, giving a total of five hours of NMRT (or placebo). This was given on an outpatient basis.
The device is made up of twelve independently controlled coil systems that are spaced orthogonally. These are designed to produce a 3-dimensional therapy field. Along with a separately generated permanent magnetic field, the 3-dimensional therapy field forms a nuclear resonance field in the center of the coil system. The desired dose of NMRT is achieved with the help of MBST® - Treatment software, which is controlled by a computer chip card. The device can generate a magnetic field of 3.0 mT (typical) and maximum of 10 mT extending up to 30 cm around the device.
Patients were called for review at 1 week (1w), 1 month (1m), 3 months (3m) and 6 months (6m) when clinical examination, WOMAC osteoarthritis index and OKS were repeated. They were also asked to record VAS and details of painkillers taken during the week before each review. Due to the lack of recognised analgesia equivalencies, the quantity of pain killers taken were graded with reference to the amount and frequency taken at baseline - less than baseline was graded as 1, same as baseline was graded as 2 and more than baseline was graded as 3.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Scotland
-
Aberdeen, Scotland, United Kingdom, AB15 6XS
- Woodend Hospital
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Osteoarthrosis of the knee(s)
- Moderately severe (grade 1-2)
Exclusion Criteria:
- Prior knee surgery
- Implanted metallic devices
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: Placebo - no therapy
Patients who were blinded but did not receive therapy
|
5 treatment where MRI therapy machine was switched off (both patient and therapist blinded to this by use of electronic 'prescription cards').
(n=50)
Other Names:
|
Experimental: MRI therapy
Patients receiving MRI therapy but blinded to it
|
5 treatments with magnetic field delivered to knee (n=50)
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Oxford Knee Score
Time Frame: 12 weeks
|
Patient administered validated questions
|
12 weeks
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Simon L Barker, MD, NHS Grampian
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 06/S0802/131
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Osteoarthrosis
-
University Hospital, BordeauxCompleted
-
Sahlgrenska University Hospital, SwedenUnknownOsteoarthrosis, KneeSweden
-
Waldemar Link GmbH & Co. KGRecruitingOsteoarthrosis of KneeColombia
-
Cedars-Sinai Medical CenterMusculoskeletal Transplant FoundationCompletedOsteoarthrosis of the Carpometacarpal Joint of the ThumbUnited States
-
Faculdade de Ciências Médicas da Santa Casa de...CompletedKnee Osteoarthritis | Knee Arthritis
-
Hanan JafarRecruitingKnee OsteoarthrosisJordan
-
Hanan JafarRecruitingKnee OsteoarthrosisJordan
-
Columbia UniversityAmerican Society for Surgery of the Hand; Arthritis FoundationRecruitingOsteoarthrosis of the Carpometacarpal Joint of the ThumbUnited States
-
University of UtahCompletedOsteoarthrosis of the Carpometacarpal Joint of the ThumbUnited States
-
Schulthess KlinikCompletedOsteoarthrosis of the Carpometacarpal Joint of the ThumbSwitzerland
Clinical Trials on MRI therapy (off)
-
University of California, Los AngelesNational Heart, Lung, and Blood Institute (NHLBI)WithdrawnHealthy | Heart Failure With Preserved Ejection FractionUnited States
-
ReShape LifesciencesCompletedObesityUnited States, Australia
-
Universitaire Ziekenhuizen KU LeuvenRecruitingHeart Failure | Cardiomyopathy, Dilated | Left Ventricular Dyssynchrony | Cardiac Remodeling, VentricularBelgium, Switzerland, Germany, France, Poland, Romania, Brazil, Hungary, Latvia, Portugal, Spain
-
Baxter Healthcare CorporationGambro Dialysatoren GmbHWithdrawnSystemic Inflammatory Response Syndrome | Acute Kidney InjuryGermany
-
Andreas FlammerCompletedHeart FailureSwitzerland
-
Nomir Medical TechnologiesUnknown
-
Tehran University of Medical SciencesCompletedGingival RecessionIran, Islamic Republic of
-
Mount Sinai Hospital, CanadaUnknownChronic Prostatitis With Chronic Pelvic Pain SyndromeCanada
-
University of CologneUnknownSpondylolisthesis | Erosive Osteochondrosis in L2-S1Germany
-
Rapa Therapeutics LLCHackensack Meridian HealthTerminated