A Study of Dulaglutide in Chinese Participants

Pharmacokinetics of a Single Dulaglutide Dose in Healthy Chinese Subjects and of Multiple Dulaglutide Doses in Chinese Patients With T2DM

This is a study of dulaglutide in Chinese participants. The purpose of the study is to determine how the body processes dulaglutide and how dulaglutide affects the body. This study has 2 parts: Part A - single dose of dulaglutide administered to healthy participants in 2 of 3 study periods. There is a minimum 28-day washout between periods. Part A will last approximately 16 weeks. Part B - multiple doses of dulaglutide administered to participants with Type 2 diabetes mellitus (T2DM). Part B will last approximately 15 weeks.

Doses of 0.5 milligrams (mg), 0.75 mg, and 1.5 mg of dulaglutide will be evaluated in this study.

Study Overview

• Status: Completed
• Conditions: Diabetes Mellitus, Type 2; Healthy Volunteers
• Intervention / Treatment: Drug: Dulaglutide; Drug: Placebo

• Study Type: Interventional
• Enrollment (Actual): 58
• Phase: Phase 1

Contacts and Locations

Study Locations

• China
  • Beijing, China, 100034
    • For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 75 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

All Participants:

• Native Chinese (all 4 grandparents of Chinese origin)
• Male participants with female partners of child-bearing potential, or partners who are pregnant or breastfeeding, agree to use a reliable method of contraception from the time of the first dose until 3 months after the last dose of investigational product, as determined by the investigator.
• The method of contraception may be one of the following: condom with spermicidal agent, male participant sterilization, true abstinence (which is in line with the participant's usual lifestyle choice; withdrawal or calendar methods are not considered acceptable).
• Female participants not of child-bearing potential (i.e. are postmenopausal or permanently sterilized [e.g. tubal occlusion, hysterectomy, bilateral salpingectomy]). Such participants will not be required to use contraception but must test negative for pregnancy at the time of enrollment. Postmenopausal is defined as at least 1 year post cessation of menses (without an alternative medical cause) or at least 1 year of spontaneous amenorrhea, with follicle stimulating hormone (FSH) ≥40 milli international units per milliliter (mIU/mL).
• Female participants who have undergone sterilization by tubal ligation: agree to use a condom in conjunction with spermicidal gel, foam, cream, film or suppository from the time of screening until 3 months after the last dose of investigational product. Such participants must also test negative for pregnancy at the time of enrollment.

Participants with T2DM:

• Have T2DM controlled with diet or exercise alone or with a single oral agent antihyperglycemic medication (OAM) (metformin, sulfonylureas, meglitinides, acarbose [or other disaccharidase inhibitors] or thiazolidinediones) for at least 3 weeks (3 months for thiazolidinediones) before admission. Note that participants receiving sulfonylureas, meglitinides or acarbose may participate only if this treatment is stopped and metformin substituted. If switched to metformin, participants should be allowed to stabilize on metformin for 3 weeks before receiving study drug.
• If T2DM controlled with diet or exercise alone, must have a hemoglobin A1c (HbA1c) value of 6.5% to 10.5% at screening and a fasting blood glucose value of 126 to 250 milligrams per deciliter (mg/dL) (approximately 7.0 to 13.9 millimoles per liter [mmol/L]) at screening.
• If T2DM controlled with OAM(s), must have an HbA1c value of 9.0% or less at screening and a fasting blood glucose value of 110 to 200 mg/dL (approximately 6.1 to 11.1 mmol/L) at screening. If a participant's T2DM is being controlled with OAM(s) other than metformin, the participant's OAM will be stopped for at least 3 weeks before administration of study drug.

Exclusion Criteria:

All Participants:

• Have a history or presence of cardiovascular (myocardial infarction, cerebrovascular accident, venous thromboembolism), respiratory, hepatic, renal, hematological, neurological autoimmune or endocrine (except T2DM), disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; of constituting a risk when taking the study medication; or of interfering with the interpretation of data.
• Have evidence of significant active neuropsychiatric disease.
• Have poorly controlled hypertension (systolic >160 millimeters of mercury [mmHg] and/or diastolic >100 mmHg) and/or evidence of labile blood pressure including symptomatic postural hypotension.
• Have a history or presence of pancreatitis (history of chronic pancreatitis or idiopathic acute pancreatitis) or gastrointestinal disorder, for example relevant esophageal reflux or gall bladder disease, or any gastrointestinal disease which impacts gastric empty (for example, gastric bypass surgery, pyloric stenosis, with the exception of appendectomy) or could be aggravated by glucagon-like peptide-1 (GLP-1) analogs or dipeptidyl peptidase (DPP)-4 inhibitors. Participants with dyslipidemia, and participants who had cholecystolithiasis (removal of gall stones) and/or cholecystectomy (removal of gall bladder) in the past, with no further sequelae, may be included in the study at the discretion of the screening physician.
• Have personal or family history of medullary thyroid cancer (MTC) or a genetic condition that predisposes to MTC.

Participants with T2DM

• Have experienced outpatient use of insulin for control of diabetes within the past 6 months.
• Have clinically significant peripheral vascular occlusive disease in the opinion of the investigator.
• Have known severe exudative diabetic retinopathy in the opinion of the investigator.
• Have known significant autonomic neuropathy as evidenced by urinary retention, diabetic diarrhea, or gastroparesis.
• Have experienced a ketoacidotic episode (pH less than 7.3) requiring hospitalization in the last 6 months.
• Regular use of drugs that affect the glycodynamics and that directly reduce gastrointestinal motility (eg, anticholinergics, antispasmodics, 5HT3 antagonists, dopamine antagonists, and opiates) and of systemic corticosteroids by oral, intravenous, or intramuscular route, or potent, inhaled, or intranasal steroids known to have a high rate of systemic absorption.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

8

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: 0.5 mg Dulaglutide (Part A-Healthy); 0.5 milligrams (mg) dulaglutide administered once subcutaneously (SQ) to healthy participants in 1 of 3 treatment periods	Drug: Dulaglutide; Other Names: LY2189265; Drug: Placebo; Administered SQ in the placebo arms and to maintain the blind in the dulaglutide arms.
Experimental: 0.75 mg Dulaglutide (Part A-Healthy); 0.75 mg dulaglutide administered once SQ to healthy participants in 1 of 3 treatment periods	Drug: Dulaglutide; Other Names: LY2189265; Drug: Placebo; Administered SQ in the placebo arms and to maintain the blind in the dulaglutide arms.
Experimental: 1.5 mg Dulaglutide (Part A-Healthy); 1.5 mg dulaglutide administered once SQ to healthy participants in 1 of 3 treatment periods	Drug: Dulaglutide; Other Names: LY2189265; Drug: Placebo; Administered SQ in the placebo arms and to maintain the blind in the dulaglutide arms.
Placebo Comparator: Placebo (Part A-Healthy); Placebo administered once SQ to healthy participants in 1 of 3 treatment periods	Drug: Placebo; Administered SQ in the placebo arms and to maintain the blind in the dulaglutide arms.
Experimental: 0.5 mg Dulaglutide (Part B-T2DM); 0.5 mg dulaglutide administered to participants with Type 2 diabetes mellitus (T2DM) once weekly SQ for 4 weeks	Drug: Dulaglutide; Other Names: LY2189265; Drug: Placebo; Administered SQ in the placebo arms and to maintain the blind in the dulaglutide arms.
Experimental: 0.75 mg Dulaglutide (Part B-T2DM); 0.75 mg dulaglutide administered to participants with T2DM once weekly SQ for 4 weeks	Drug: Dulaglutide; Other Names: LY2189265; Drug: Placebo; Administered SQ in the placebo arms and to maintain the blind in the dulaglutide arms.
Experimental: 1.5 mg Dulaglutide (Part B-T2DM); 1.5 mg dulaglutide administered to participants with T2DM once weekly SQ for 4 weeks	Drug: Dulaglutide; Other Names: LY2189265; Drug: Placebo; Administered SQ in the placebo arms and to maintain the blind in the dulaglutide arms.
Placebo Comparator: Placebo (Part B-T2DM); Placebo administered to participants with T2DM once weekly SQ for 4 weeks	Drug: Placebo; Administered SQ in the placebo arms and to maintain the blind in the dulaglutide arms.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pharmacokinetics: Maximum Concentration (Cmax) of Dulaglutide	Pharmacokinetic parameters were assessed on Day 1 in Part A and Days 1 and 22 in Part B.	Pre-dose and 12, 24, 48, 72, 96, 168, and 336 hours post-dose
Pharmacokinetics: Time of Maximum Observed Concentration (Tmax) of Dulaglutide	Pharmacokinetic parameters were assessed on Day 1 in Part A and Days 1 and 22 in Part B.	Pre-dose and 12, 24, 48, 72, 96, 168, and 336 hours post-dose
Pharmacokinetics: Area Under the Concentration-time Curve From Time Zero to 336 Hours Postdose (AUC[0-336]) of Dulaglutide	Pharmacokinetic parameters were assessed on Day 1 in Part A and Days 1 and 22 in Part B.	Pre-dose and 12, 24, 48, 72, 96, 168, and 336 hours post-dose
Pharmacokinetics: Half-life of Dulaglutide	Pharmacokinetic parameters were assessed on Day 1 in Part A and Days 1 and 22 in Part B.	Pre-dose and 12, 24, 48, 72, 96, 168, and 336 hours post-dose

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Part B - Pharmacodynamics: Area Under the Plasma Glucose Time Curve From Time Zero to 4 Hours Postmeal (gAUC[0-4])	Pharmacodynamic parameters were assessed at baseline and on Days 3, 24, and 29 in Part B.	Baseline and Days 3, 24, and 29

Collaborators and Investigators

• Sponsor: Eli Lilly and Company
• Investigators: Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon-Fri 9 AM- 5 PM Eastern time (UTC/GMT -5 hours, EST), Eli Lilly and Company

Publications and helpful links

General Publications

• Xu J, Zhang Y, Li Y, Zhao X, Zhou W, Loghin C, Tham LS, Cui X, Cui Y, Wang W. Pharmacokinetics, Pharmacodynamics, and Safety of Dulaglutide After Single or Multiple Doses in Chinese Healthy Subjects and Patients with T2DM: A Randomized, Placebo-Controlled, Phase I Study. Adv Ther. 2022 Jan;39(1):488-503. doi: 10.1007/s12325-021-01921-5. Epub 2021 Nov 17.

Study record dates

Study Major Dates

• Study Start: August 1, 2012
• Primary Completion (Actual): June 1, 2014
• Study Completion (Actual): June 1, 2014

Study Registration Dates

• First Submitted: August 15, 2012
• First Submitted That Met QC Criteria: August 15, 2012
• First Posted (Estimate): August 17, 2012

Study Record Updates

• Last Update Posted (Estimate): March 7, 2016
• Last Update Submitted That Met QC Criteria: February 8, 2016
• Last Verified: February 1, 2016

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Physiological Effects of Drugs; Dulaglutide
• Other Study ID Numbers: 12925; H9X-EW-GBDL (Other Identifier: Eli Lilly and Company)