Satiating Effects of Isolated Soy Proteins

Comparison of the Satiating Effects of Differentially Processed Isolated Soy Proteins

Proteins are known to be more satiating than the other macronutrients; however, the type and amount of protein needed to induce a significant effect on satiety (fullness between meals) is sometimes difficult to determine. In this study, 2 differentially processed isolated soy proteins will be tested for satiety using subjective visual analogue scales. The amount of food consumed following intake of the isolated soy proteins will be measured 3 hours after consuming the proteins. The hypothesis is that differentially processed isolated soy proteins will show unique satiety responses.

Study Overview

• Status: Completed
• Conditions: Weight Management
• Intervention / Treatment: Dietary supplement: Dry-Blended Beverage

• Study Type: Interventional
• Enrollment (Actual): 40
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Canada
  • Ontario
    • Toronto, Ontario, Canada, M5C2N8
      • Glycemic Index Laboratories

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• BMI between 20 and 30 kg/m2
• Age between 18-65y
• Unrestrained eater (score<12)
• Regularly consume 3 meals per day
• Moderate exercise (eg running, aerobics classes, other sports activities) of no more than 7 hours per week

Exclusion Criteria:

• use of drugs that influence carbohydrate or lipid metabolism (eg. hypoglycemic agents, antibiotics taken less than 6 weeks before study entry, glucocorticoids, anti-diarrheal medication, weight loss medication, and anti-diabetic medication)
• presence of any significant disease (eg gastrointestinal diseases, diabetes, a CVD event less than 12 weeks from study entry, current hepatic disease, etc)
• use of special dietary treatments within 4 weeks of study (eg weight loss diet, extremely high or low carbohydrate/protein/fat diet, use of meal replacements more than once a day)
• use of supplements within 1 week of study (does not include vitamin supplements or supplements which are routinely taken and were initiated 4 weeks before the study and which will be continued during the study period)
• restrained eater (score>12)
• weight change (absolute body weight change of ≥ 10%) within the previous 6 weeks
• alcohol intake >2 drinks/day
• food allergies of any kind
• swallowing difficulties
• exercising more than 7 hours per week

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: RANDOMIZED
• Interventional Model: CROSSOVER
• Masking: QUADRUPLE

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Test ISP-10; 10 grams of the test ISP will be consumed as a dry-blended beverage	Dietary supplement: Dry-Blended Beverage
EXPERIMENTAL: Test ISP-20; 20 grams of the test ISP will be consumed as a dry-blended beverage	Dietary supplement: Dry-Blended Beverage
ACTIVE_COMPARATOR: Control ISP-10; 10 grams of the control ISP will be consumed as a dry-blended beverage	Dietary supplement: Dry-Blended Beverage
ACTIVE_COMPARATOR: Control ISP-20; 20 grams of the control ISP will be consumed as a dry-blended beverage	Dietary supplement: Dry-Blended Beverage

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Subjective Satiety	Measure subjective satiety using visual analogue scales	3 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Ad Libitum Food Intake	At the end of 3 hours after consuming test diets, measure the amount of food consumed for 30 mins	30 minutes

Collaborators and Investigators

• Sponsor: DuPont Nutrition and Health
• Investigators: Principal Investigator: Thomas Wolever, MD, Glycemic Index Laboratories, Inc; Principal Investigator: Alexandra Jenkins, PhD, Glycemic Index Laboratories, Inc

Study record dates

Study Major Dates

• Study Start: November 1, 2012
• Primary Completion (ACTUAL): June 1, 2013
• Study Completion (ACTUAL): November 1, 2013

Study Registration Dates

• First Submitted: November 15, 2012
• First Submitted That Met QC Criteria: November 15, 2012
• First Posted (ESTIMATE): November 21, 2012

Study Record Updates

• Last Update Posted (ACTUAL): October 7, 2019
• Last Update Submitted That Met QC Criteria: October 3, 2019
• Last Verified: October 1, 2019

More Information

Terms related to this study

• Keywords: obesity, isolated soy protein, satiety, food intake
• Other Study ID Numbers: GIL-1245