- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01749501
Premedication for Non-Emergency Endotracheal Intubation In the NICU
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The investigators project will study two different strategies of pre-medication in an attempt to eliminate the pain and discomfort associated with the elective intubation procedure. The study will be blinded and patients will be randomized in two different arms according to gestational age and identified by study number for pre-medication protocols. Demographic as well as study information prior, during and post intubation attempt will be recorded and closely monitored. Each patient will be monitored for study purposes for at least 24 hours after intubation attempt to record any potential side effects of the medication. The investigators plan to have a data safety monitoring board established composed of three pediatric doctors / specialists not associated with this study.
The response of paralysis, onset and duration will be assessed clinically. Onset of muscle relaxation will be described as the absence of spontaneous movements and flaccidity, measured in seconds from the end of the medication administration. Duration of paralysis will be determined by the difference in time from the onset of paralysis to the return of spontaneous movements and pre-intubation tone
Study Type
Enrollment (Actual)
Phase
- Phase 4
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion criteria:
- Infants admitted to the NICU at Beaumont Children's Hospital Royal Oak and Troy.
- Gestational Age 28 0/7 weeks (or post menstrual age 28 0/7 weeks) or higher
- Infants who require endotracheal intubation on a non-emergent basis
- Signed informed consent by parents
Exclusion criteria:
- intubations that occurred in the delivery room or for other emergent basis,
- absence of intravenous access
- abnormality of the airway
- known or family history of neuromuscular disorder
- renal insufficiency (urine output <0.6 mL/kg per hour or creatine >1.7 mg/dL if > 1 day of age)
- known hepatic insufficiency (abnormal liver function or coagulation laboratory results)
- Current diagnosis of pulmonary hypertension
- Any infant deemed by the attending neonatologist as unstable or unfit for the study
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: Placebo
|
Normal saline same amt as 0.6mg/kg of study drug
|
Active Comparator: Rocuronium
0.6 mg/kg once
|
0.6 mg/Kg once
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Present the Percentage of Participants With an Excellent Ease of Intubation Rating
Time Frame: 24 hours after intubation period
|
percentage of participants with an excellent ease of intubation rating based on Scale of 1-4 (1 Being Excellent, 4 Being Poor),"
|
24 hours after intubation period
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Timing of Entire Procedure (Stopwatch)and Recording Number of Attempts to Successful Intubation Recorded.
Time Frame: 24 hours after intubation procedure
|
24 hours after intubation procedure
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Martin Espinosa, MD, William Beaumont Hospitals
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Respiratory Tract Diseases
- Respiration Disorders
- Lung Diseases
- Infant, Newborn, Diseases
- Infant, Premature, Diseases
- Respiratory Distress Syndrome
- Respiratory Distress Syndrome, Newborn
- Physiological Effects of Drugs
- Peripheral Nervous System Agents
- Neuromuscular Agents
- Neuromuscular Nondepolarizing Agents
- Neuromuscular Blocking Agents
- Rocuronium
Other Study ID Numbers
- 2010-271
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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