Relationship Between Vestibular Function and Topographic Memory

January 30, 2013 updated by: Biomedical Development Corporation

The Relationship Between Vestibular Function and Topographic Memory

The purpose of this study is to evaluate visual and nonvisual topographic memory impairment and its relationship to vestibular function in humans. Topographic memory refers to the ability to remember current and past locations in topographic (navigational) space and to make and/or adjust to spatial transformations using such memories. Performance on each of these topographic memory tasks will be compared to performance on a set of comparable nontopographic memory tasks. Topographic impairments represent some of the earliest cognitive deficits observed in Alzheimer's Disease, and the brain areas involved in topographic memory are the first to show degenerative changes.

Study Overview

Status

Unknown

Conditions

Study Type

Observational

Enrollment (Anticipated)

50

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Texas
      • San Antonio, Texas, United States, 78215
        • Ears of Texas, PA
      • San Antonio, Texas, United States, 78229
        • Michael Roman, PhD, LSSP

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

70 years to 85 years (Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Nominally healthy adults between the ages of 70 and 85 yrs who meet inclusion/exclusion criteria. All study participants will be recruited from the San Antonio community.

Description

Inclusion Criteria:

  • Males or females of all racial and ethnic groups between the ages of 70 and 85 years of age;
  • Montreal Cognitive Assessment (MOCA) (http://www.mocatest.org) score of >24;
  • No known history or current evidence of stroke, trauma, psychiatric illness, or other insult to the brain;
  • No current use of psychoactive medicine other than caffeine (100 mg/day) or alcohol (1-2 drinks per night);
  • Normal sleep (at least an average of 7 hours for four days prior to participation);
  • Able and willing to comply with study requirements including following instructions to complete vestibular and neuropsychological testing; and
  • Have full understanding of all elements of provide signature and dating of the written informed consent prior to the initiation of procedures specified in protocol.

Exclusion Criteria:

  • <70 or >85 yrs of age;
  • MOCA score of <25;
  • History, or current evidence, of stroke, trauma, psychiatric illness, or other insult to the brain;
  • Prior history of inner-ear balance problems;
  • Current use of psychoactive medicine other than moderate caffeine or alcohol use;
  • Acute or chronic sleep deprivation during the week prior to participation (<7 hours/night on average for four nights prior to participation).

Other Restrictions:

  • No alcohol use on the night before the vestibular testing
  • 7 hours minimum sleep the night before vestibular testing
  • No eye make-up can be worn on the day of the vestibular test due to possible interference with vestibular-ocular reflex testing apparatus

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Prospective

Cohorts and Interventions

Group / Cohort
Study Group

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Determine relationship between topographic memory and vestibular function
Time Frame: 14 days
14 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Biomedical Development Corporation

Collaborators

National Center for Advancing Translational Sciences (NCATS)
Michael Roman, PhD, LSSD
Ears of Texas, PA

Investigators

  • Principal Investigator: Fred Previc, PhD, Biomedical Development Corporation

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

February 1, 2013

Primary Completion (Anticipated)

April 1, 2013

Study Completion (Anticipated)

June 1, 2013

Study Registration Dates

First Submitted

January 29, 2013

First Submitted That Met QC Criteria

January 29, 2013

First Posted (Estimate)

January 31, 2013

Study Record Updates

Last Update Posted (Estimate)

February 1, 2013

Last Update Submitted That Met QC Criteria

January 30, 2013

Last Verified

January 1, 2013

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 121101-R43TR000645-01
  • R43TR000645 (U.S. NIH Grant/Contract)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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