Mortality Following Surgery for Proximal Femoral Fractures (HipMo)

Proximal femoral fractures are most frequent traumatologic and orthopedic diagnoses undergoing surgery. It affect most seniors and accompanied by a series of complications. The aim of our retrospective clinical trial is to establish a thirty-day mortality rate after surgical solutions, mortality during hospitalization and compare the types of anesthesia chosen during the performance (general vs. subarachnoid anesthesia).

Study Overview

• Status: Completed
• Conditions: Fracture of Neck of Femur (Hip)
• Intervention / Treatment: Procedure: hip fracture surgery

Detailed Description

We evaluate relationship between the monitored parameters and 30 day survival.

Observed parameters:

• age of the patient
• sex of the patient
• 90 days mortality rate
• American Society of Anesthesiologists (ASA) score
• time since injury and surgery (hours)
• whether surgery was initiated during the day (7:00 - 20:00) or at night (20:00-07:00)
• type of administered anesthesia (GA, epidural anaesthesia, Subarachnoid (spinal) block)
• hemoglobin level prior to surgery
• haemotransfusion administration during surgery
• perioperative administration of vasopressors
• anesthetist erudition (with / without accomplished residency)
• surgeon erudition (with / without accomplished residency)

• Study Type: Observational
• Enrollment (Actual): 369

Contacts and Locations

Study Locations

• Czech Republic
  • Jihomoravský Kraj
    • Brno, Jihomoravský Kraj, Czech Republic, 62500
      • Faculty hospital Brno

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 110 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

isolated fracture of proximal femur indicated for surgery

Description

Inclusion Criteria:

• isolated fracture of proximal femur indicated for surgery

Exclusion Criteria:

• children under 18 years
• none isolated trauma
• isolated fracture of proximal femur without surgery

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Retrospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
patients after surgery with isolated proximal femur fracture; Patients between 18-110 years admitted to Faculty Hospital Brno with isolated injury of proximal femur (ICD dg. S72.0 a S72.1)who underwent surgery between 1.1. 2011 00:00 - 31.12. 2012 23:59 in Faculty hospital Brno (tertiary care university hospital).	Procedure: hip fracture surgery; we evaluate the relationship between the monitored parameters and 30 day survival

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
in hospital mortality rate	number of deaths from hospital admission to discharge (percent)	2 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
30 days mortality rate	number of deaths within 30 days after injury (percent)	2 years

Collaborators and Investigators

• Sponsor: Brno University Hospital
• Collaborators: St. Anne's University Hospital Brno, Czech Republic
• Investigators: Study Director: Petr Štourač, MD, Ph.D., Brno Faculty Hospital, departement of anesthesiology and intensive care medicine

Publications and helpful links

General Publications

• O'Hara DA, Duff A, Berlin JA, Poses RM, Lawrence VA, Huber EC, Noveck H, Strom BL, Carson JL. The effect of anesthetic technique on postoperative outcomes in hip fracture repair. Anesthesiology. 2000 Apr;92(4):947-57. doi: 10.1097/00000542-200004000-00011.
• Pearse RM, Moreno RP, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent JL, Hoeft A, Rhodes A; European Surgical Outcomes Study (EuSOS) group for the Trials groups of the European Society of Intensive Care Medicine and the European Society of Anaesthesiology. Mortality after surgery in Europe: a 7 day cohort study. Lancet. 2012 Sep 22;380(9847):1059-65. doi: 10.1016/S0140-6736(12)61148-9.
• Dzupa V, Bartonicek J, Skala-Rosenbaum J, Prikazsky V. [Mortality in patients with proximal femoral fractures during the first year after the injury]. Acta Chir Orthop Traumatol Cech. 2002;69(1):39-44. Czech.

Helpful Links

• open access link to full-text

Study record dates

Study Major Dates

• Study Start: December 1, 2012
• Primary Completion (Actual): May 1, 2015
• Study Completion (Actual): May 1, 2015

Study Registration Dates

• First Submitted: March 6, 2013
• First Submitted That Met QC Criteria: March 7, 2013
• First Posted (Estimate): March 8, 2013

Study Record Updates

• Last Update Posted (Estimate): July 26, 2016
• Last Update Submitted That Met QC Criteria: July 22, 2016
• Last Verified: July 1, 2016

More Information

Terms related to this study

• Keywords: anesthesia; hip fracture; proximal femur; pertrochanteric fracture; subtrochanteric fracture; subcapital fracture; safety issue
• Additional Relevant MeSH Terms: Wounds and Injuries; Leg Injuries; Hip Injuries; Hip Fractures; Femoral Fractures; Fractures, Bone; Femoral Neck Fractures
• Other Study ID Numbers: KARIM FN Brno

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No