Single Application of Desensitizing Pastes as Dentin Sensitivity Treatment

Clinical Evaluation of the Effectiveness of Immediate Relief Obtained With Desensitizing Creams - A Controlled, Randomized, Triple Masked, Split-Mouth Clinical Trial

Sponsors

Lead Sponsor: Federal University of São Paulo

Source Federal University of São Paulo
Brief Summary

The aim of this study was to evaluate the efficacy of three desensitizing toothpastes for immediate and intermediate-term relief of CDH, when compared with a control toothpaste. One hundred and thirty-eight hypersensitive teeth were diagnosed and randomized into four groups according to the therapeutic agent of each desensitizing cream tested: 1) strontium acetate and calcium carbonate, 2) calcium carbonate and arginine 8%, 3) calcium phosphate nanoparticles and 4) a control toothpaste. The desensitizing creams were applied according to the manufacturer's instructions. Cervical dentin hypersensitivity was assessed at baseline, immediately, 24 hours and 30 days after the treatment. Cold and evaporative tests were used to assess the sensitivity level.

Overall Status Completed
Start Date April 2013
Completion Date August 2013
Primary Completion Date August 2013
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
cervical dentin hypersensitivity 30 days
Enrollment 138
Condition
Intervention

Intervention Type: Procedure

Intervention Name: Colgate

Description: Slow-speed handpiece with a Robson brush for 3 seconds by repeating the procedure

Arm Group Label: Colgate

Intervention Type: Procedure

Intervention Name: Sensodyne

Description: Digital application for 60 seconds.

Arm Group Label: Sensodyne

Intervention Type: Procedure

Intervention Name: Nano P

Description: Slow-speed handpiece with a Robson brush for 10 seconds

Arm Group Label: Nano P

Intervention Type: Procedure

Intervention Name: Cocorico

Description: Digital application for 60 seconds

Arm Group Label: Cocorico

Eligibility

Criteria:

Inclusion Criteria:

- subjects 18 years or older

- in good general and oral health; have complaint of CDH in teeth distributed in all 4 quadrants

- not making use of desensitizing agents

- not having undergone periodontal treatment over the past 3 months

- respond to evaporative stimulus with a score ≥ 1.5 cm on VAS

Exclusion Criteria:

- patients who presented restorations and caries near the exposed dentin of the hypersensitive teeth

- who made frequent use of painkillers, anti-inflammatory and antidepressants drugs

Gender: All

Minimum Age: 22 Years

Maximum Age: 48 Years

Healthy Volunteers: Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
Olga D Flecha, PhD Principal Investigator Federal University of São Paulo
Location
Facility: Periodontics Clinic, Department of Dentistry
Location Countries

Brazil

Verification Date

December 2013

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Federal University of São Paulo

Investigator Full Name: Olga Flecha

Investigator Title: PhD

Has Expanded Access No
Condition Browse
Number Of Arms 4
Arm Group

Label: Sensodyne

Type: Experimental

Description: Digital application for 60 seconds.

Label: Colgate

Type: Experimental

Description: Slow-speed handpiece with a Robson brush for 3 seconds by repeating the procedure

Label: Nano P

Type: Experimental

Description: Slow-speed handpiece with a Robson brush for 10 seconds

Label: Cocorico

Type: Placebo Comparator

Description: Digital application for 60 seconds

Study Design Info

Allocation: Randomized

Intervention Model: Crossover Assignment

Primary Purpose: Treatment

Masking: Triple (Participant, Care Provider, Investigator)

Source: ClinicalTrials.gov