Adductor Canal Versus Femoral Nerve Block for Analgesia Post Total Knee Arthroscopy

December 31, 2014 updated by: Changi General Hospital

A Randomised Controlled Trial Comparing Single Shot Adductor Canal Block With Femoral Nerve Block for Analgesia Post Total Knee Arthroplasty

Total knee arthroplasty or replacement (TKA) is a surgery performed for osteoarthritis of the knee which is increasingly performed as the population ages. It is a painful surgery and one of the methods to reduce post-operative pain is performing a regional anaesthesia technique. The current practice is to perform a femoral nerve block (FNB) which blocks the nerves supplying the knee joint and the thigh muscles (quadriceps). This provides effective analgesia. However, it also results in weakness of the quadriceps and may result in falls post-operatively.

Adductor canal block (ACB) is a new, alternative regional anaesthesia technique which is hypothesised to provide as effective analgesia, with less quadriceps weakness compared to FNB, hence potentially reducing the risk of falls post-operatively.

Investigators aim to study if the analgesia provided by ACB is as good as FNB while preserving quadriceps strength.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Singapore
      • Singapore, Singapore, 529889
        • Recruiting
        • Changi General Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

45 years to 85 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • ages 45-85
  • American Society of Anaesthesiologists physical status 1-3
  • BMI 18-35 kg/m2

Exclusion Criteria:

  • inability to give consent, communicate, cooperate
  • Patients with regular consumption of strong opioids (morphine, oxycodone) or steroids
  • Patients with allergy to local anaesthetics or any drugs included in the study
  • Patients with lower limb surgery in the preceding year
  • Patients with pre-existing neurological deficits
  • Patients who are unsuitable for general anaesthetics (eg difficult airway)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Femoral Nerve Block
Femoral Nerve block performed with 0.5% Ropivacaine 30mls (150mg)
Drug: Ropivacaine
30mls of 0.5% ropivacaine
Other Names:
  • naropin
Active Comparator: Adductor Canal block
Adductor Canal block performed with 0.5% Ropivacaine 30mls (150mg)
Drug: Ropivacaine
30mls of 0.5% ropivacaine
Other Names:
  • naropin

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Morphine consumption
Time Frame: first 24 hours
first 24 hours

Secondary Outcome Measures

Outcome Measure
Time Frame
Morphine consumption
Time Frame: 48 hours
48 hours
Pain scores
Time Frame: 1, 6, 12, 24, 48
1, 6, 12, 24, 48
Side effects of opioids- sedation, nausea and vomiting
Time Frame: 48 hours
48 hours
Quadriceps strength, ability to mobilise
Time Frame: 24, 48 hours
24, 48 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Changi General Hospital

Investigators

  • Principal Investigator: Yean Chin Lim, MBBS, MMed, Changi General Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2014

Primary Completion (Actual)

September 1, 2014

Study Completion (Anticipated)

December 1, 2014

Study Registration Dates

First Submitted

January 9, 2014

First Submitted That Met QC Criteria

January 9, 2014

First Posted (Estimate)

January 13, 2014

Study Record Updates

Last Update Posted (Estimate)

January 1, 2015

Last Update Submitted That Met QC Criteria

December 31, 2014

Last Verified

January 1, 2014

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2013/ 921/ D

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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