Working Memory Training in Adults With Substance Abuse and Executive Function Deficits.

October 22, 2015 updated by: Rickard Ahlberg, Örebro Läns Landsting

Computerized Working Memory Training in Adults With Substance Abuse and Executive Function Deficits: A Randomised Controlled Trial.

The purpose of this study is to evaluate the effects of a computerized working memory training program on substance abuse, psychosocial functioning, cognitive performance and psychiatric problems in adults with substance abuse and attention problems.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

The primary aim of this study is to examine the effects of 5 weeks of computerized working memory training on substance abuse. Secondary aims are to explore whether effects are mediated by changes in executive functions and/or moderated by personality. Also, effects on measures of psychosocial functioning, depression, anxiety and attention will be explored. Follow-up assessment will be conducted at 6 months post training.

Study Type

Interventional

Enrollment (Anticipated)

100

Phase

  • Phase 2

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Sweden
      • Örebro, Sweden, 701 16
        • Recruiting
        • Psychiatric Research Centre
        • Contact:
        • Principal Investigator:
          • Lars Kjellin, docent

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 70 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Treatment seeking adults with substance abuse and executive function deficits.

Exclusion Criteria:

  • Acute intoxication or abstinence symptoms of any substance.
  • Psychosis.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Cogmed working memory training
30-40 minutes of Cogmed computerized working memory training 3-5 days a week for 5-8 weeks. Every training session consists of a set of visual- and verbal working memory tasks that are trained on during the session.
Behavioral: Computerized Cogmed working memory training
Computerized working memory training with Cogmed QM software. The QM software consists of a set of verbal and visual working memory tasks which is trained for 25-40 minutes each session.
Active Comparator: Treatment as usual
Treatment as usual can consist of medication, psychotherapy, counseling, and psychological assessment. After a 8 week period participants in this arm well be offered Cogmed working memory training.
Behavioral: Treatment as usual
Treatment as usual can consist of medication, psychotherapy, counseling, and psychological assessment.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Change from baseline in substance abuse measured with Substance abuse scales in Adult Self Report (ASR; ASEBA).
Time Frame: Baseline and at 25 weeks
Baseline and at 25 weeks

Secondary Outcome Measures

Outcome Measure
Time Frame
Change from baseline in Adult Self Report (ASR; ASEBA) Attention problems scale.
Time Frame: Baseline and at 25 weeks
Baseline and at 25 weeks
Change from baseline in Adult Self Report (ASR; ASEBA) Internalizing index.
Time Frame: Baseline and at 25 weeks
Baseline and at 25 weeks
Change from baseline in Adult Self Report (ASR; ASEBA) Externalizing index.
Time Frame: Baseline and at 25 weeks
Baseline and at 25 weeks
Change from baseline in Adult Self Report (ASR; ASEBA) Adaptive functioning scales.
Time Frame: Baseline and at 25 weeks
Baseline and at 25 weeks
Change from baseline in Executive functioning measured with Behavior Rating Inventory of Executive Function-Adult (BRIEF-A).
Time Frame: Baseline and at 25 weeks
Baseline and at 25 weeks
Change from baseline in verbal working memory measured with performance on Digit span.
Time Frame: Baseline and at 25 weeks
Baseline and at 25 weeks
Change from baseline in visual working memory measured with performance on Span board.
Time Frame: Baseline and at 25 weeks
Baseline and at 25 weeks
Change from baseline in focused attention measured with performance on Conners Continuous Performance Test-II (CCPT-II).
Time Frame: Baseline and at 25 weeks
Baseline and at 25 weeks
Change from baseline in vigilance measured with performance on Conners Continuous Performance Test-II (CCPT-II).
Time Frame: Baseline and at 25 weeks
Baseline and at 25 weeks
Change from baseline in reading speed measured with performance on Reading speed in Diagnostic Reading and Writing Test (DLS; Swedish version).
Time Frame: Baseline and at 25 weeks
Baseline and at 25 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Örebro Läns Landsting

Investigators

  • Study Director: Lars Kjellin, Docent, Orebro lans landsting

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2014

Primary Completion (Anticipated)

December 1, 2016

Study Completion (Anticipated)

December 1, 2016

Study Registration Dates

First Submitted

February 19, 2014

First Submitted That Met QC Criteria

February 20, 2014

First Posted (Estimate)

February 21, 2014

Study Record Updates

Last Update Posted (Estimate)

October 23, 2015

Last Update Submitted That Met QC Criteria

October 22, 2015

Last Verified

October 1, 2015

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • RA02

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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