The Effect of Ingesting or Rinsing Sucrose and Sucralose on Self-control, Cognitive Performance, and Blood Glucose

The Effects of Ingesting or Rinsing Sucrose and Sucralose Solutions on Self-control, Cognitive Performance, and Blood Glucose Level

The purpose of this study is to examine the effects of ingesting or mouth rinsing a sucrose (carbohydrate) versus a sucralose (carbohydrate-free) drink on self control, cognitive performance, and blood glucose level.

Study Overview

• Status: Completed
• Conditions: Cognitive Performance; Blood Glucose Response; Self-control
• Intervention / Treatment: Dietary supplement: Ingestion of solution; Dietary supplement: Rinising of solution

• Study Type: Interventional
• Enrollment (Actual): 40
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United Kingdom
  • Leeds, United Kingdom, LS29JT
    • Human Appetite Research Unit (University of Leeds)

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years to 65 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• BMI 18 - 29 kg/m2

Exclusion Criteria:

• Dementia
• Depression
• Type 2 diabetes
• Phenylketonuria
• Intake of medication known to affect glucose metabolism
• Fasting blood glucose > 7.8 mmol/L

Study Plan

How is the study designed?

Design Details

• Primary Purpose: BASIC_SCIENCE
• Allocation: NON_RANDOMIZED
• Interventional Model: CROSSOVER
• Masking: SINGLE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
ACTIVE_COMPARATOR: Sucrose (50g); A 381g blackcurrant drink (cordial and water) providing 50g of sucrose	Dietary supplement: Ingestion of solution; Participants will ingest the solution; Dietary supplement: Rinising of solution; Participants rinse the solution in the oral cavity
PLACEBO_COMPARATOR: Sucralose (0.92 g sugars); A 381g blackcurrant drink (cordial and water) providing 0.92g of natural sugars	Dietary supplement: Ingestion of solution; Participants will ingest the solution; Dietary supplement: Rinising of solution; Participants rinse the solution in the oral cavity

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Capillary blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions	Change from baseline in capillary blood glucose (assessed by lancet fingerprick and YSI blood glucose analyser)	- 30, -15, - 5, + 5, + 10, + 20, + 30, + 40 minutes relative to rinsing or ingestion of sucrose or sucralose solutions (each separated by 7 days in crossover manner)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Visual verbal learning and memory performance following self-control depletion	Visual verbal learning performance will be assessed by the Visual Verbal Learning Test (Rey, 1964) following a self-control depletion task and ingestion or rinsing of a sucrose or sucralose solution	+ 35 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner)
Attention switching performance following self-control depletion	Attention switching performance will be assessed by a switch task (Rogers and Monsell, 1995) following a self-control depletion task and ingestion or rinsing of a sucrose or sucralose solution	+ 20 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner)
Continuous blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions	A subgroup of 10 participants recruited into the study will be fitted with a continuous glucose monitoring device (CGMS, iPRO) the day preceding each of the test days to measure continuous interstitial blood glucose levels	24 hours preceding and during ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in a crossover manner)

Collaborators and Investigators

• Sponsor: University of Leeds
• Collaborators: Sugar Nutrition, UK
• Investigators: Principal Investigator: Neil B Boyle, University of Leeds; Study Chair: Louise Dye, University of Leeds

Study record dates

Study Major Dates

• Study Start: January 1, 2014
• Primary Completion (ACTUAL): August 1, 2014
• Study Completion (ACTUAL): August 1, 2014

Study Registration Dates

• First Submitted: February 26, 2014
• First Submitted That Met QC Criteria: February 28, 2014
• First Posted (ESTIMATE): March 3, 2014

Study Record Updates

• Last Update Posted (ESTIMATE): May 12, 2016
• Last Update Submitted That Met QC Criteria: May 11, 2016
• Last Verified: May 1, 2016

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pharmaceutical Solutions
• Other Study ID Numbers: SN - 0114

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED