- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02101957
Multicentric Trial of the Treatment of Huntington's Disease by Cysteamine (RP103)
April 1, 2014 updated by: University Hospital, Angers
The purpose of this study is to evaluate the effect of cysteamine in patients with symptomatic Huntington's disease by comparing two groups of patients (cysteamine vs placebo) on the results of the Unified Huntington's Disease Rating Scale (UHDRS, Huntington study group 1996).
Study Overview
Study Type
Interventional
Enrollment (Actual)
96
Phase
- Phase 2
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
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Angers, France, 49000
- CHU Angers
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
16 years to 63 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Clinically disease-registered for at least one year, leading to consult (abnormal movements, neuropsychiatric disorders, neuropsychological impairment).
- Unified Huntington's Disease Rating Scale motor ≥ 5
- Total Functional Capacity > 10 (≥ 11)
- Huntington Disease diagnosed with abnormal number of CAG repeats: 38 < nucleotide expansion (CAG)
- Age between 18 and 65
- Voluntarily Patient Consent
- Patients willing and able to take oral medications, and comply with the specific procedures of the study
Exclusion Criteria:
- Severe cognitive impairment or neuropsychiatric troubles.
- No drug compliance to previous treatment.
- Patients with contra indication to the realization of imaging studies (including claustrophobia ) .
- Patients who have not given their written and informed consent signed .
- No national health insurance affiliation
- Private patients of their liberty by judicial or administrative decision, or patients under supervision.
- Pregnant women ( pregnancy test will be carried out systematically for women at risk) or lactating .
- Women who could become pregnant during the study period and with no contraception.
- Patients who have developed hypersensitivity to cysteamine or penicillamine ( against indication of cysteamine ) .
- Brain Damage intercurrent MRI. Brain morphological abnormalities , other than those characteristic of the disease .
- Disease - associated with neurological repercussions.
- Affection - visceral serious , scalable , involving life-threatening.
- Mental - disorder may disrupt accession to the Protocol , including a history of spontaneous and / or drug-induced hallucinations history of severe depression that required repeated hospitalizations , history of repeated suicide attempts .
- Participation in progress, or interrupted for less than three months, a therapeutic protocol of Huntington's disease .
- Patients with a history of surgical interventions to improve the symptoms of Huntington 's disease such as graft neuron, deep brain stimulation, infusion of neurotrophic agent
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: RP103
RP103 capsule, 16 capsules per day
|
|
Placebo Comparator: placebo
placebo capsule, 16 capsules per day
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Unified Huntington's Disease Rating Scale motor
Time Frame: at 18 months
|
at 18 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
October 1, 2010
Primary Completion (Anticipated)
July 1, 2015
Study Registration Dates
First Submitted
March 25, 2014
First Submitted That Met QC Criteria
April 1, 2014
First Posted (Estimate)
April 2, 2014
Study Record Updates
Last Update Posted (Estimate)
April 2, 2014
Last Update Submitted That Met QC Criteria
April 1, 2014
Last Verified
July 1, 2013
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Mental Disorders
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
- Neurocognitive Disorders
- Genetic Diseases, Inborn
- Basal Ganglia Diseases
- Movement Disorders
- Neurodegenerative Diseases
- Dyskinesias
- Heredodegenerative Disorders, Nervous System
- Dementia
- Cognition Disorders
- Chorea
- Huntington Disease
Other Study ID Numbers
- PHRC2004-03bis
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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