Combined and Isolated Effects of Sleep Deprivation and Alcohol Intake on Exercise Performance in Humans.

Combined and Isolated Effects of Sleep Deprivation and Alcohol Intake on Cardiorrespiratory, Neuromuscular and Hormonal Responses in Healthy Males.

Although the effects of acute alcohol intake and sleep deprivation on exercise performance lacks evidence in the literature, in many situations, they occur simultaneously. Once the alcohol affects physiological processes, the processes that occur during sleep can be impaired, such as: suppression of GH release, action of neurotransmitters and neuromodulators in the CNS, changes in the proportion of sleep stages and may lead to suppression of REM sleep. These changes promote a significant functional impairment such as a reduction in alertness and modification in reaction time, which affects the performance of any activity of daily and professional life. However, the combined effects on the physical performance variables, such as aerobic and neuromuscular performance lack of evidence in the literature.

Study Overview

• Status: Completed
• Conditions: Sleep Deprivation; Alcohol Intake
• Intervention / Treatment: Other: Alcohol intake; Other: Sleep deprivation

Detailed Description

Ten subjects were randomized in four situations after familiarization and control situation: (1) alcohol intake combined with sleep normal; (2) alcohol intake combined with sleep deprivation; (3) placebo intake combined with sleep normal and (4) placebo intake combined with sleep deprivation.

• Study Type: Interventional
• Enrollment (Actual): 10
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Brazil
  • Rio Grande do Sul
    • Porto Alegre, Rio Grande do Sul, Brazil, 90690200
      • Exercise Research Laboratory

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 30 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

- Physical active men

Exclusion Criteria:

• AUDIT questionnaire above 15 points
• Nocturnal Chronotype
• Skeletal muscle injuries in upper and lower limb
• Metabolic and cardiovascular disease

Study Plan

How is the study designed?

Design Details

• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Alcohol intake; 1 g/kg of etanol combined. Beer without alcohol in the same volume will be used to placebo condition.	Other: Alcohol intake; The subjects will be drink beer (with or without alcohol) before sleep intervention (normal sleep and sleep deprivation).; Other: Sleep deprivation; One night of sleep deprivation or one night of normal sleep.
Active Comparator: sleep deprivation; one night of sleep deprivation will be compared to 8h of normal sleep.	Other: Alcohol intake; The subjects will be drink beer (with or without alcohol) before sleep intervention (normal sleep and sleep deprivation).; Other: Sleep deprivation; One night of sleep deprivation or one night of normal sleep.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Aerobic Performance	Aerobic performance will be determined through the subject's heart rate	After each sequence, up to 8 hours
Neuromuscular Performance	knee extensor isometric torque	After each sequence, up to 8 hours
Biochemical Responses	Glucose after each situation in the morning	After each sequence, up to 8 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Hydration Status	Urine Specific Gravity	After each sequence, up to 8 hours
Profile of Mood States		6 months
Breath Alcohol		6 months

Collaborators and Investigators

• Sponsor: Federal University of Rio Grande do Sul
• Collaborators: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil
• Investigators: Principal Investigator: Rodrigo Rodrigues, MSc, Federal University of Rio Grande do Sul

Study record dates

Study Major Dates

• Study Start: October 1, 2013
• Primary Completion (Actual): May 1, 2015
• Study Completion (Actual): May 1, 2015

Study Registration Dates

• First Submitted: April 14, 2014
• First Submitted That Met QC Criteria: April 15, 2014
• First Posted (Estimate): April 17, 2014

Study Record Updates

• Last Update Posted (Estimate): December 21, 2016
• Last Update Submitted That Met QC Criteria: October 27, 2016
• Last Verified: October 1, 2016

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Drinking Behavior; Nervous System Diseases; Dyssomnias; Sleep Wake Disorders; Neurologic Manifestations; Alcohol Drinking; Sleep Deprivation
• Other Study ID Numbers: UFRGS 366465

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No