- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02124525
N-acetylcysteine for Tobacco Smoking (NACNOS)
The Efficacy of N-acetylcysteine as a Cessation Treatment for Tobacco Smoking and Oxidative Stress Reduction
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The study will be conducted at the Center of Smoking Cessation, at State University (UEL), in Brazil. A sample of 32 outpatients will be selected, that are refractory to first-line smoking cessation treatment. All patients included in this study under the condition of understanding and signing the informed consent after approval of the research by Ethics Research Committee of UEL. Prior to randomization into the clinical trial, all participants will be assessed with a questionnaire to provide information about demographic, smoking history, nicotine dependence, depressive disorder, anthropometric measurements such as , height, weight, body mass index (BMI), waist circumference (WC), as well as heart rate (HR) and blood pressure (BP).The diagnostic criteria for research for depressive disorder and tobacco use disorder will be assed by trained psychiatrists according to the Structured Clinical Interview. The primary outcome measurement will be the significant reduction on the number of cigarettes/day. Secondary outcome measurements will be: reduction on the exhaled Carbon Monoxide, reduction of Hamilton Depression Rating Scale scores, improvement on Sheehan Quality of Life scale measurements.
The Fagerstrom Test for nicotine dependence (FTND) will be used to assess the severity of tobacco by dependence FTND. The FTND has a scale of six items and the score 0-10. The cutoff point for FTND nicotine dependence will be > 5. The assessment of severity of depression among study participants will be conducted by using Hamilton Depression Rating Scale- 17 items (HDRS). HDRS was translated and adapted for the Brazilian population. Minnesota Nicotine Withdrawal Scale (MNWS) MNWS is a 5-point scale (none, slight, mild, moderate, severe) to measure withdrawal symptoms.The scale assesses the damage that the patient is having due to illness. It is a self - administered scale consisting of 3 items. A score of 0-10 corresponds to the patient's opinion. Assesses the disability damage in three areas: 1) occupational, 2) social life, leisure, 3) family life, activities, and household activities. Can be scored 0-10, 0-3 mild injury, 4-6 moderate damage and 7-10 injury grave.The number of pack-years was calculated according to the definition: the number of cigarettes smoked per day multiplied by number of years smoked and divided by 20 (1 pack has 20 cigarettes).This clinical trial was designed to investigate the efficacy of NAC as a treatment for tobacco use disorder. Data were collected by face-to-face interview at baseline and weeks 4, 8 and 12. Smoking status was also evaluated using exhaled carbon monoxide (COEXH). COEXH was measured using a Micro CO Meter with an electrochemical sensor (Micro CO - Micro Medical Ltd, Rochester, Kent, UK). All participants were instructed to breathe deeply and to hold their breath for 20 seconds and then to exhale slowly and completely through a mouthpiece. Smoking reduction was validated by breath carbon monoxide concentration, and the cut-off point for COEXH levels will be categorized as ≤ 6ppm for smoking cessation (Middleton et al., 2000). Both groups will receive monthly meetings of Group Behavioral Therapy during the course of the study.
Participants (n=32) were randomized into two groups 16 patients in each group, in a double-blind manner to receive NAC or placebo. The dose of NAC was 3000mg/day administered in 500 mg capsules in two daily doses, 3 capsules in the morning and 3 in the evening. The chosen dosage was based on previous studies in which similar dosages had shown to be effective and well tolerated.
Individuals were randomized to NAC or placebo, each group have individuals with equal gender, age, scores of FTND and depressive disorders.
Statistical analysis will be performed with repeated measurements design analyses of variance, and post hoc t test.
Study Type
Enrollment (Anticipated)
Phase
- Phase 3
Contacts and Locations
Study Contact
- Name: Eduardo Prado, MD
- Phone Number: 55-43-9929-1702
- Email: eduardostp@hotmail.com
Study Contact Backup
- Name: Sandra Nunes, MD
- Phone Number: 55-43-9801-9111
- Email: sandranunes@sercomtel.com.br
Study Locations
-
-
PR
-
Londrina, PR, Brazil, 86055-900
- Recruiting
- Hospital das Clínicas da Universidade Estadual de Londrina (Londrina State University Clinical Hospital)
-
Contact:
- Sinésio Moreire, M.D.
- Phone Number: 5770 55-43-33714000
- Email: gerclinhc@uel.br
-
Sub-Investigator:
- Eduardo Prado, MD
-
Principal Investigator:
- Sandra Nunes, MD PhD
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Current daily smoker of 10 or more cigarettes per day
- Capacity to consent to the study and follow its instructions and procedures
- Female participants will need to be utilizing effective contraception if of childbearing age
- Must be able to swallow the pills
Exclusion Criteria:
- Clinically unstable medical or psychiatric disorders that require acute treatment
- Active gastrointestinal ulcers
- Pregnancy or breastfeeding
- Current use of vitamin supplements or other substances with recognized antioxidant action
- A history of anaphylactic reaction to NAC or any component of the preparation
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: N-acetylcysteine
Subjects receiving N-acetylcysteine (NAC): 6 pills/ day of N-acetylcysteine 500mg. Duration: 12 weeks |
N-acetylcysteine 3000mg a day for 12 weeks versus Placebo for 12 weeks
Other Names:
|
Placebo Comparator: Placebo
Placebo will be taken for 12 weeks
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The efficacy of N-acetylcysteine in reducing of the cigarettes per day
Time Frame: At Baseline and after 12 weeks (endpoint)
|
The primary outcome will be the significant reduction of the cigarettes per day
|
At Baseline and after 12 weeks (endpoint)
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Efficacy of N-acetylcysteine in reducing exhaled Carbon Monoxide
Time Frame: At Baseline and after 12 weeks (endpoint)
|
The secondary outcomes will be the significant reduction of the exhaled Carbon Monoxide
|
At Baseline and after 12 weeks (endpoint)
|
Collaborators and Investigators
Investigators
- Principal Investigator: Sandra Nunes, MD, PhD, Londrina State University - Center of Smoking Cessation
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- UEL 33553/2011
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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