- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02303314
Efficacy of Oral Trigonella Foenum-graecum Seed Extract Vs Placebo in Treatment of None Alcoholic Fatty Liver Disease
September 21, 2017 updated by: Amir Hossein Babaei, Shiraz University of Medical Sciences
This study design to examine performance of trigonella foenum-graecum (TFG) in treatment of non-alcoholic fatty liver disease.
Base on inclusion and exclusion criteria, 50 patients select and then randomize into intervention and control groups.
Two group use capsules which contain TFG or placebo, respectively.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
This study design to examine performance of trigonella foenum-graecum in treatment of non-alcoholic fatty liver disease.
Patients 18-70 year old with the levels of ALT and AST greater than 1.5 and less than 10 times normal level, and ultrasound evidence confirm fatty liver disease include in study.
Patients with alcohol consumption, other liver disease and taking medications that cause liver injury, exclude.
Base on inclusion and exclusion criteria, 50 patients select and then randomize into intervention and control groups.
Control group, in addition to diet and exercise recommendations take placebo capsules for 3 months.
Intervention group, in addition to diet and exercise recommendations, use capsules containing hydro-alcoholic extract of fenugreek 1g/d for 3 months.
At baseline and 6 and 12 weeks after intervention, the investigators measure FBS, insulin, insulin resistance, Albumin, Aspartate transaminase, Alanine Aminotransferase, Alkaline phosphatase, Total bilirubin, Direct bilirubin, HbA1c, total cholesterol, LDL, HDL, TG, High sensitivity C reactive protein and Creatinine.
At baseline and 12 weeks after intervention fibroscan perform to evaluate the amount of fat in liver.
In order to decrease bias, patient, physician who performs fibroscan and the person analyzing the data are blind to group drugs.
Study Type
Interventional
Enrollment (Actual)
35
Phase
- Phase 2
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Fars
-
Shiraz, Fars, Iran, Islamic Republic of
- shiraz University of medical sciences
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 70 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion criteria:
- The level of ALT and AST greater than 1.5 and less than 10 times normal level
- Ultrasound evidence confirm fatty liver disease; age between 18-70 years old
- Negative pregnancy test for women in reproductive age (up to two weeks prior to the study)
- Negative for hepatitis B and C
- BMI: 18.5 to 40
- Sign the consent form.
Exclusion criteria:
- History of more than one unit of alcohol consumption (one value for the Spirits (vodka; whiskey)
- Wine and Beer are respectively 30-45 cc; 120-150 cc and 360 cc.)
- Fatty liver controller medications
- Glucose lowering drugs
- Cholesterol lowering drugs
- Hypotensive drugs
- Consumption of vitamin E
- Taking coenzyme Q10
- Administration of corticosteroids & glucocorticoids
- Thyroxin administration
- Administration of drugs that cause fatty liver
- Diabetes (type 1 and 2)
- History of cancer in the past
- Hepatocellular carcinoma
- Renal failure (creatinine> 1.5 x ULN)
- Chronic pancreatitis
- Cirrhosis
- Uncontrolled hypertension (above 180 mm Hg systolic blood pressure); heart disease
- Autoimmune hepatitis
- Primary biliary cirrhosis
- Primary sclerosing cholangitis (alkaline phosphatase levels greater than 3 times normal)
- Wilson's disease
- Alpha-1 antitrypsin deficiency and coronary artery disease
- Symptoms of hypothyroidism
- Hyperthyroidism
- Disorders of the hypothalamic - pituitary
- Liver transplantation
- Pregnant or lactating women
- Those who cannot use contraceptives.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: Drug: Trigonella Foenum-graecum
in this group patients use Trigonella Foenum-graecum seed extract twice daily.
|
|
Other: Drug: Placebo
in this group patients use placebo twice daily.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Liver stiffness change
Time Frame: At baseline and 12 weeks after intervention
|
Assessment by Fibroscan
|
At baseline and 12 weeks after intervention
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Seyed Alireza Taghavi, shiraz University of medical sciences
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
November 1, 2014
Primary Completion (Actual)
August 1, 2017
Study Completion (Actual)
September 1, 2017
Study Registration Dates
First Submitted
November 21, 2014
First Submitted That Met QC Criteria
November 24, 2014
First Posted (Estimate)
November 27, 2014
Study Record Updates
Last Update Posted (Actual)
September 25, 2017
Last Update Submitted That Met QC Criteria
September 21, 2017
Last Verified
September 1, 2017
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- CT-P-9362-6352 (Other Identifier: Shirazums)
- IRCT2013102015083N1 (Registry Identifier: Iranian Registry of Clinical Trials)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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