Comparison of Emergence and Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia

Comparison of Emergence and Recovery Time, and Evaluation of Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia in Lung Surgery- A Pilot Study

Which is more adequate general anesthetic agent, desflurane or propofol, for emergence and recovery time, and perioperative oxygenation in lung resection surgery?

Study Overview

• Status: Active, not recruiting
• Conditions: Lung Cancer
• Intervention / Treatment: Drug: desflurane; Drug: propofol

Detailed Description

The investigators plan to investigate the effects of desflurane on oxygenation (prevention of HPV) of OLV compare with propofol which is used in general anesthesia for lung resection.

Transesophageal echocardiography (TEE) wiill be used to measure pulmonary blood flow during surgery visible and successively. To confirm the effect of HPV by measuring the change in pulmonary blood flow. The correlation between the blood oxygen concentration and attenuation of blood flow will be investigated.

• Study Type: Interventional
• Enrollment (Actual): 80
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Japan
  • Tokyko
    • Bunkyo-ku, Tokyko, Japan, 113-8421
      • University of Juntendo

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 75 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Patients agree to participate in the study
• Patients undergoing lung cancer surgery requiring one-lung ventilation.
• American Society of Anesthesiologists Physical Status Class 1 or 2

Exclusion Criteria:

• Patients with any of the following will be excluded from lung cancer patients.
• New York Heart Association Classification more than 2
• Respiratory dysfunction Vital Capacity or percent predicted Forced expiratory volume in one second is less than 50 %
• Pulmonary hypertension with mean pulmonary arterial pressure more than 30 mmHg
• Coagulation dysfunction
• The administration of steroids and immunosuppressive agents within 3 months prior to surgery
• Infection with active inflammation
• Pneumonectomy patients
• Cases of epidural anesthesia is contraindicated

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Desflurane; Desflurane group: this group of patients receives desflurane as the main anesthetic agent in addition to remifentanil infusion at 0.1~0.3 mcg/kg/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.	Drug: desflurane; Desflurane group: this group of patients receives desflurane as the main anesthetic agent during one-lung anesthesia. Propofol group: this group of patients receives propofol as the main anesthetic agnet during on-lung anesthesia.; Other Names: Suprene
Active Comparator: Propofol; Propofol group: this group of patients receives propofol as the main anesthetic agent in addition to remifentanil infusion at the rate of 0.1~0.3 mcg./g/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.	Drug: propofol; Propofol group:this group of patients receives propofol as the main anesthetic agent during one-lung anesthesia.; Other Names: Diprivan

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Oxygenation	Arterial blood gases are monitored.Pulmonary blood flow is measured using transesophageal echocardiogram.	prior to surgery to one-hour after extubation

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Rapidity of Emergence From Anesthesia	Time to extubation and orientation, where the patient is.	one minute after cessation of anethetic agents to one hour after extubation
Quality of Consiousness	quality of consciousness will be assessed using Aldrete score	after extubation
Postoperative Nausea and Vomiting	degree of nausea and frequency of vomiting	on the postoperative day 1

Collaborators and Investigators

• Sponsor: Juntendo University
• Collaborators: Baxter Healthcare Corporation
• Investigators: Principal Investigator: Eiichi Inada, M.D., Juntendo University

Study record dates

Study Major Dates

• Study Start: October 1, 2012
• Primary Completion (Actual): June 1, 2016
• Study Completion (Estimated): December 1, 2024

Study Registration Dates

• First Submitted: December 15, 2014
• First Submitted That Met QC Criteria: December 23, 2014
• First Posted (Estimated): December 24, 2014

Study Record Updates

• Last Update Posted (Actual): April 5, 2024
• Last Update Submitted That Met QC Criteria: April 2, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Keywords: one-lung ventilation, oxygenation
• Additional Relevant MeSH Terms: Physiological Effects of Drugs; Central Nervous System Depressants; Anesthetics, Intravenous; Anesthetics, General; Anesthetics; Hypnotics and Sedatives; Anesthetics, Inhalation; Propofol; Desflurane
• Other Study ID Numbers: 12-97