Pedal Rate Influence on Oxygen Consumption in Eccentric (PRIOx)

Nowadays, ECC exercise can be realized using various modalities that target small or large muscle masses in a segmentary or dynamic way. The training program proposed in this study is realised on an handmade ergocycle which allows eccentric contractions.

With this type of ergometer, O2 consumption (VO2) is three to five fold lower than during an exercise realised at the same power output with a concentric ergocycle. Due to this later propertie, which origins are not yet fully identified, there is an increasing interest to embed ECC in rehabilitation programs.

The investigators hypothesis that a higher pedal rate will induce a lower oxygen consumption, with the same benefits.

This study aims to compare oxygen consumption at two pedal rates : 50 and 80 rotation per minute (rpm).

The ultimate goal is to assess efficacy and tolerance of eccentric training on ergocycle and to enhance comprehension of the physiological mecanisms involved in the lower O2 consumption observed.

Study Overview

• Status: Unknown
• Conditions: Healthy
• Intervention / Treatment: Procedure: pedal rate on 50 RPM; Procedure: pedal rate on 80 RPM

Detailed Description

The training program proposed in this study is realised on an handmade ergocycle which allows almost pur eccentric contractions.

Fifteen healthy volunteers realize a incremental test until exertion on a concentric ergometer. If the minimal power output of 200W is reached, the volunteers are familiarized with eccentric exercise during several bouts of exercise. This habituation session allows avoiding the secondary muscular effects of high intensity eccentric exercise.

Then, volunteers could take part in a two-stepped eccentric protocol: 1) an incremental test consisting in 3 stages. Each stage lasts 4 minutes.

2) A constant-load test realized at 320W during 6 minutes. Each test is realized twice: at 50 and 80 rpm and sequence is randomly assigned.

[One step (incremental or constant load) = two tests (50 and 80 rpm)]

During each step, oxygen consumption is continuously measured, as well as cardiac output and muscular activity and intramuscular oxygen kinetic.

• Study Type: Interventional
• Enrollment (Anticipated): 15
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Clermont-Ferrand, France, 63003
    • Recruiting
    • CHU clermont-ferrand

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 55 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• - Males
• IMC <30
• physically active
• Pmax concentric > 200W
• Pmax > Pmax théo sédentaire

Exclusion Criteria:

• cardio pulmonary, osteo articulary or muscular diseases
• Eccentric based physical activities or sports (weight liftering, alpine skiing)

Study Plan

How is the study designed?

Design Details

• Allocation: Randomized
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: pedal rate ON 50 RPM	Procedure: pedal rate on 50 RPM; All measurements are performed in two pedalling situations. The two frequencies used will be 50 and 80 RPM. For each subject the running order (50 and 80, 80 and 50) is randomly determined
Experimental: pedal rate on 80 RPM	Procedure: pedal rate on 80 RPM; All measurements are performed in two pedalling situations. The two frequencies used will be 50 and 80 RPM. For each subject the running order (50 and 80, 80 and 50) is randomly determined

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Oxygen consumption (VO2 ml/min)	Oxygen consumption (VO2) is continuously assesse during exercises at 50 and 80 rpm.	at day 1

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cardiac output( l/min)		at day 1
muscular oxygen kinetic (arbitrary unit and %)		at day 1
Muscular activity (mV)	Muscular activity is measured during one and half minute, at the end of each stage	at day 1 during one and half minute (1min30s)
VO2 (ml/min)	VO2 is continously assessed during the constant-load exercise	at day 1

Collaborators and Investigators

• Sponsor: University Hospital, Clermont-Ferrand

Study record dates

Study Major Dates

• Study Start: August 1, 2015
• Primary Completion (Anticipated): September 1, 2016
• Study Completion (Anticipated): October 1, 2016

Study Registration Dates

• First Submitted: July 9, 2015
• First Submitted That Met QC Criteria: November 2, 2015
• First Posted (Estimate): November 3, 2015

Study Record Updates

• Last Update Posted (Estimate): July 29, 2016
• Last Update Submitted That Met QC Criteria: July 28, 2016
• Last Verified: July 1, 2016

More Information

Terms related to this study

• Keywords: Ergometer; Oxygen consumption; Eccentric; Pedal rate; Only health volunteers
• Other Study ID Numbers: CHU-0241