- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02616042
The Effect of New Dentifrices Containing Centella Asiatica and Bamboo Salt on Reducing Plaque and Gingivitis
The Effect of New Dentifrices Containing Centella Asiatica and Bamboo Salt on Reducing Plaque and Gingivitis: a Randomized Clinical Trial
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
With growing interest in plant-based products among researchers, many toothpastes with various herbal extracts have been introduced over the past few decades,Centella asiatica (CA), a small herb broadly cultivated in China, Southeast Asia, India and Oceanic countries, has long been used for therapeutic purposes since ancient times.CA has been reported to be useful in the treatment of skin diseases wound repair and healing of burn. In dentistry, few studies have explored the efficacy of CA. In one study, CA was demonstrated to be an effective supportive agent following periodontal treatment, resulting in reduced plaque and gingivitis. In spite of such wound healing properties of CA, its usage in dental field has been limited.
Bamboo salt (BS) is a Korean folk remedy consisting of sea salt roasted in bamboo which has long been used for therapeutic purposes in Korea. Toothpastes containing BS has been sold in Korea for some decades. Some in vitro studies and animal studies using rats demonstrated anti-inflammatory effects of BS. Nevertheless, no human study has yet evaluated the effect of BS on periodontal health.
Therefore, the new dentifrice containing CA and BS was developed.
Study Type
Enrollment (Actual)
Phase
- Phase 3
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Systemical healthy individual
- Normal alignment of teeth
Exclusion Criteria:
- Recent antibiotic treatment
- Existence of dental caries or periodontitis
- Those needs emergency dental treatments
- Natural teeth less than 20
- Denture wearer
- Oral appliance for orthodontic treatment
- Pregnant
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Centella asiatica and bamboo salt
Participants received a dentifrice which contains Centella asiatica, bamboo salt, dental-type silica, sodium fluoride and aminocaproic acid.
Each participant brushed their teeth using only the assigned dentifrices for 3 minutes twice a day (after breakfast and before bedtime).
All participants used the assigned dentifrices for 4 days in each trial cycle.
|
Participants uses three types of dentifrices for four days after each wash-out period of 10 days.
Dentifrice with Centella asiatica and bamboo salt is compared with control dentifrice.
Participants uses three types of dentifrices for four days after each wash-out period of 10 days.
Dentifrice with Centella asiatica is compared with control dentifrice.
|
Experimental: Centella asiatica
Participants received a dentifrice which contains Centella asiatica, dental-type silica, sodium fluoride and aminocaproic acid.
Each participant brushed their teeth using only the assigned dentifrices for 3 minutes twice a day (after breakfast and before bedtime).
|
Participants uses three types of dentifrices for four days after each wash-out period of 10 days.
Dentifrice with Centella asiatica and bamboo salt is compared with control dentifrice.
Participants uses three types of dentifrices for four days after each wash-out period of 10 days.
Dentifrice with Centella asiatica is compared with control dentifrice.
|
Placebo Comparator: Control dentifrice
Participants received a plain dentifrice which contains dental-type silica, sodium fluoride and aminocaproic acid.
Each participant brushed their teeth using only the assigned dentifrices for 3 minutes twice a day (after breakfast and before bedtime).
|
Participants uses three types of dentifrices for four days after each wash-out period of 10 days.
Dentifrice with Centella asiatica and bamboo salt is compared with control dentifrice.
Participants uses three types of dentifrices for four days after each wash-out period of 10 days.
Dentifrice with Centella asiatica is compared with control dentifrice.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Gingivitis
Time Frame: Four day
|
Gingival index is measured
|
Four day
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Dental plaque
Time Frame: Four day
|
Plaque index is measured
|
Four day
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Hyun-Duck Kim, DDS, PhD, Seoul National University
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- CRI09001
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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