Relationship Between Muscle Mass and Muscle Relaxation Time

May 2, 2016 updated by: Go Eun Bae

Relationship Between Muscle Mass Measured by Bioelectrical Impedance Analysis and Muscle Relaxation

Rocuronium block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. There have been several studies reported positive relationship between muscle mass and amount of neuromuscular junction. The purpose of this study is to find relationship between muscle mass and muscle relaxation time.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Rocuronium block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. There have been several studies reported positive relationship between muscle mass and amount of neuromuscular junction. Until now, dose of rocuronium has been judged by patient's weight and height. However, height and weight do not represent exact muscle mass. The purpose of this study is to find relationship between muscle mass and muscle relaxation time. Measurement of muscle mass will be obtained using bioelectrical impedence analysis.

Study Type

Interventional

Enrollment (Actual)

42

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

19 years to 64 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • All patient who undergo general anesthesia.
  • Male; weight 70-75kg , height 170-175cm
  • Female; weight 53-58kg , height 158-163cm

Exclusion Criteria:

  • Liver and kidney disease
  • Any types of muscle disorder.
  • Metal materials or pacemaker in body

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Supportive Care
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Inbody
Participant measure muscle mass by bioelectrical impedance analysis (Inbody 720, Seoul, Korea) after fast for eight hours.
Device: Inbody
Participant measure muscle mass by bioelectrical impedance analysis (Inbody 720, Seoul, Korea) after fast for eight hours. After measurement, patient is induced anesthesia. Rocuronium dose is 12mg for male, and 9mg for female.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
ratio of result of first stimulus(T1) to result of supramaximal stimulation(T0)
Time Frame: two hours
T1 and T0 is obtained by train of four which is commonly used neuromuscular monitoring device.
two hours

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
completely suppression time of result of first stimulus(T1).
Time Frame: ten minutes
T1 is obtained by train of four which is commonly used neuromuscular monitoring device.
ten minutes

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Time until reoccurrence of response of first stimulus(T1).
Time Frame: two hours
T1 is obtained by train of four which is commonly used neuromuscular monitoring device.
two hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Go Eun Bae

Investigators

  • Study Director: Seung Zhoo Yoon, MD, PhD, Korea University Anam Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

December 1, 2015

Primary Completion (Actual)

May 1, 2016

Study Completion (Actual)

May 1, 2016

Study Registration Dates

First Submitted

November 23, 2015

First Submitted That Met QC Criteria

November 25, 2015

First Posted (Estimate)

December 1, 2015

Study Record Updates

Last Update Posted (Estimate)

May 4, 2016

Last Update Submitted That Met QC Criteria

May 2, 2016

Last Verified

May 1, 2016

More Information

Terms related to this study

Other Study ID Numbers

  • Inbody

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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