Genetic Basis of Rosacea Study (Control)

Expansion Arm of Papulopustular Rosacea Gene Expression Profiling to Include Normal Individuals as Anatomic Site Specific Controls

Rosacea is a common disease characterized by inflammation and vascular abnormalities of the facial skin and ocular surface. It it considered to be a syndrome encompassing various combinations of cutaneous signs including flushing, erythema, telangiectasia, papules, edema, ocular lesions, and rhinophyma. The exact etiology of cutaneous rosacea is unknown but is characterized by persistent vasodilation, increased vascular permeability, and vascular hyper-reactivity of the microcirculation of the central part of the face. The purpose of this study is to develop gene expression profiles of papulopustular rosacea compared to those of normal skin. The investigator hopes to better understand the abnormal gene functions that might contribute to this condition. This understanding may lead to the development of additional and better treatments for rosacea.

Study Overview

• Status: Completed
• Conditions: Rosacea
• Intervention / Treatment: Other: Skin Biopsy

• Study Type: Interventional
• Enrollment (Actual): 10
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • California
    • Redwood City, California, United States, 94603
      • Stanford Dermatology

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion criteria include:

1. Fitzpatrick skin type II or III
2. Age greater than or equal to 18 years
3. Individuals without a history of rosacea

Exclusion criteria include:

1. Women who are pregnant or lactating
2. Use of topical prescription medications or procedures to the face within one month of enrollment
3. Skin conditions that might interfere with interpretation of procedure results (at the discretion of the investigator)

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Diagnostic
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Control Group; Participants who do not have rosacea (control group)	Other: Skin Biopsy; Skin biopsies will be performed via the Keys punch technique from normal facial skin.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Gene expression profile of papulopustular rosacea compared to normal skin and skin from individuals without rosacea.	Up to 2 years

Collaborators and Investigators

• Sponsor: Stanford University
• Investigators: Principal Investigator: Anne Chang, Stanford University

Study record dates

Study Major Dates

• Study Start (Actual): January 21, 2016
• Primary Completion (Actual): August 1, 2016
• Study Completion (Actual): August 1, 2016

Study Registration Dates

• First Submitted: April 18, 2016
• First Submitted That Met QC Criteria: April 20, 2016
• First Posted (Estimate): April 25, 2016

Study Record Updates

• Last Update Posted (Actual): September 26, 2019
• Last Update Submitted That Met QC Criteria: September 24, 2019
• Last Verified: September 1, 2019

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Skin Diseases; Rosacea
• Other Study ID Numbers: 22419

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No