The Effects of Rhus Coriaria L. on Body Weight (SomaghWeight)

The Effects of Rhus Coriaria L. (Rhus or Somagh) on Body Weight

The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as "Somagh" on body weight.

Study Overview

• Status: Completed
• Conditions: Body Weight
• Intervention / Treatment: Drug: Rhus Coriaria L.(Rhus); Drug: Placebo

Detailed Description

Rhus coriaria L.(Rhus) is a well-known spice widely consumed in the world which has also been utilized extensively for medicinal purposes. The antioxidant components of this plant made it a favorable target for laboratory and animal studies in different conditions such as oxidative stress cytotoxicity, diabetes and hyperlipidemia. Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrheic, antiseptic, anorexic and antihyperglycemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes.

The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as Somagh on body weight.

• Study Type: Interventional
• Enrollment (Actual): 50
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Iran, Islamic Republic of
  • Fars
    • Shiraz, Fars, Iran, Islamic Republic of
      • Shahid Motahhari Clinic, Shiraz University of Medical Sciences

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 60 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Body mass index (BMI) >= 25 kg/m2

Exclusion Criteria:

• Diabetes mellitus
• Hypo. or hyperthyroidism
• Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure
• Use of drugs: Weight lowering agents, glucocorticoids, Oral contraceptive pills.
• Pregnancy
• History of allergic reaction to Somagh

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Quadruple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo; 500 mg twice daily after meal for 6 weeks	Drug: Placebo; 500 mg twice daily after meals for 6 weeks
Experimental: Rhus; 500 mg twice daily after meal for 6 weeks	Drug: Rhus Coriaria L.(Rhus); 500 mg twice daily after meals for 6 weeks; Other Names: Somagh

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Body Mass Index	6 weeks

Secondary Outcome Measures

Outcome Measure	Time Frame
Waist Circumference (cm)	6 weeks
Hip Circumference (cm)	6 weeks
Leptin (ng/ml)	6 weeks
Insulin (mU/l)	6 weeks
Fasting Blood Glucose (mg/dl)	6 weeks
Number of patients with adverse event	6 weeks

Collaborators and Investigators

• Sponsor: Shiraz University of Medical Sciences
• Investigators: Study Chair: Gholamhossein Ranjbar Omrani, MD, Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences; Principal Investigator: Mojtaba Heydari, MD, Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran; Principal Investigator: Zahra Hajmohammadi, MD, Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Study record dates

Study Major Dates

• Study Start: May 1, 2016
• Primary Completion (Actual): September 1, 2016
• Study Completion (Actual): September 1, 2016

Study Registration Dates

• First Submitted: April 26, 2016
• First Submitted That Met QC Criteria: April 26, 2016
• First Posted (Estimate): April 28, 2016

Study Record Updates

• Last Update Posted (Actual): August 23, 2018
• Last Update Submitted That Met QC Criteria: August 22, 2018
• Last Verified: September 1, 2016

More Information

Terms related to this study

• Keywords: Body mass index; Waist Circumference; Herbal medicine; Rhus; Medicine, Traditional; Body weight changes; Waist-Hip Ratio
• Additional Relevant MeSH Terms: Body Weight
• Other Study ID Numbers: CT-92-5581

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED