Study of Neurophysiological Correlates of the Link Between Perception and Action (PSM_EEG)

Study of Neurophysiological Correlates of the Link Between Perception and Action Through Varied Protocols of Sensorimotor Studies

The main goal of this study is to better understand the link between motor system (action) and perception in variable sensorial forms by examining the time course and the dynamic of electroencephalography (EEG) activations. To do so, differents sensimotor study protocols in linguistics and in the fiels of emotional and spatial perception will be realised in order to study prcisely differents links parception-action.

Study Overview

• Status: Completed
• Conditions: Healthy Volunteer
• Intervention / Treatment: Other: Sensorial stimulations; Other: Experimental protocols; Behavioral: Emotional protocols; Other: Protocol with a spatial dimension

• Study Type: Interventional
• Enrollment (Actual): 228
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Laurent Vercueil, Doctor; Phone Number: 04 76 76 54 88; Email: LVercueil@chu-grenoble.fr
• Study Contact Backup: Name: Alexandre Krainik, Professor; Phone Number: 04 56 52 05 86; Email: AKrainik@chu-grenoble.fr

Study Locations

• France
  • La Tronche, France, 38700
    • UniversityHospitalGrenoble

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Signed free consent
• Medical exam done before participation to the study
• Age between 18 and 65 years
• Baccalaureate as minimum degree level

Exclusion Criteria:

• Subject already taking part in an other clinical and/or therapeutic trial still in progress
• Important audition or visual disorder
• Language disorders (aphasia, dysphasia, dysarthria, stammer, etc)
• Any counter-argument to MRI
• Pregnant, parturient or brest feeding women. A pregnancy test (urinary) will be offered to female participants during the inclusion medical interview. In the event of a refusal the woman will have to sign a discharge attesting that she doesn't take any risk of getting pregnant and to volunteer to participate to the trial without having recourse to the offered prgnancy test.
• Patient derpived of liberty by a judicial or administrative decision
• Patient under 18 years under a legal protection or unable to express their consent
• Alcohol ingested

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Healthy volunteers	Other: Sensorial stimulations; Other: Experimental protocols; Behavioral: Emotional protocols; Other: Protocol with a spatial dimension

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Electroencephalography (EEG)	Software : Brain Analyzer. Hz	20 minutes
Electrooculography (EOG)	mV	Half an hour
Electromyography EMG	EMG Delsys sans fil Trigno Digital system. mV	Half an hour
Electrodermal conductance	EDA device from BrainProduct society. Constant voltage of 0,5V	Half an hour
Anatomical MRI		15 minutes

Collaborators and Investigators

• Sponsor: University Hospital, Grenoble
• Investigators: Principal Investigator: Laurent Verceuil, Doctor, Grenoble Hospital University

Publications and helpful links

General Publications

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• Jackson PL, Meltzoff AN, Decety J. How do we perceive the pain of others? A window into the neural processes involved in empathy. Neuroimage. 2005 Feb 1;24(3):771-9. doi: 10.1016/j.neuroimage.2004.09.006.
• Singer T, Seymour B, O'Doherty J, Kaube H, Dolan RJ, Frith CD. Empathy for pain involves the affective but not sensory components of pain. Science. 2004 Feb 20;303(5661):1157-62. doi: 10.1126/science.1093535.
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• Bellier, L., Mazzuca, M., Thai-Van, H., Caclin, A. & Laboissière, R. (2013). Categorization of speech in early auditory evoked responses. INTERSPEECH, page 911-915. ISCA, (2013)
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• Campagne, A., Petit-Boulanger, C., Pebayle, T., Muzet, A., Priez, A. (2004). Electrodermal responses according to mental and emotional loads in driving situations: influence of workload. International Conference on Traffic and Transport Psychology, Nottingham, 5-9 September 2004.
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• Decety, J., & Lamm, C. (2009). The biological basis of empathy. In J. T. Cacioppo & Bernston, G. G. (Eds.), Handbook of Neuroscience for the Behavioral Sciences. New York: John Wiley and Sons.
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• Fradcourt B. (2014). Caractérisation du traitement visuel de scènes naturelles émotionnelles : Evaluations comportementales et en Imagerie par Résonance Magnétique fonctionnelle. Thèse de doctorat, Grenoble.
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• Lamm C, Batson CD, Decety J. The neural substrate of human empathy: effects of perspective-taking and cognitive appraisal. J Cogn Neurosci. 2007 Jan;19(1):42-58. doi: 10.1162/jocn.2007.19.1.42.
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• Niedenthal PM, Mermillod M, Maringer M, Hess U. The Simulation of Smiles (SIMS) model: Embodied simulation and the meaning of facial expression. Behav Brain Sci. 2010 Dec;33(6):417-33; discussion 433-80. doi: 10.1017/S0140525X10000865.
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• Schwartz, J.; Basirat, A.; Ménard, L. & Sato, M. (2012) The Perception-for-Action-Control Theory (PACT): A perceptuo-motor theory of speech perception. Journal of Neurolinguistics, 25, 336-354.
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• Vermeulen N, Chang B, Corneille O, Pleyers G, Mermillod M. Verifying properties of concepts spontaneously requires sharing resources with same-modality percept. Cogn Process. 2013 Mar;14(1):81-7. doi: 10.1007/s10339-012-0533-1. Epub 2013 Feb 15.

Study record dates

Study Major Dates

• Study Start (Actual): March 16, 2015
• Primary Completion (Actual): March 16, 2024
• Study Completion (Actual): March 16, 2024

Study Registration Dates

• First Submitted: July 27, 2016
• First Submitted That Met QC Criteria: July 27, 2016
• First Posted (Estimated): August 1, 2016

Study Record Updates

• Last Update Posted (Actual): April 22, 2024
• Last Update Submitted That Met QC Criteria: April 18, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Keywords: Link; Neurophysiological; Perception-action
• Other Study ID Numbers: 38RC14.420