- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02870478
The Effects of Low Concentration Atropine on Pupil Size and Accommodation
A Study of Time and Dose-dependent Effect of Low Concentration Atropine on Accommodation and Pupil Size
Study Overview
Detailed Description
Myopia has become an epidemic in developed countries, particularly in Asian countries and in the United States. Myopia, or near-sightedness, is a result of uncontrolled axial elongation of the eye. Besides needing optical correction in order to see clearly, myopia can result in many sight-threatening complications, such as retinal thinning, retinal holes and tears, retinal detachment, and vascular proliferation. Atropine drops have been used in clinical practice for over 100 years at varying concentrations and different dosing regimens. The proposed small study seeks to establish evidence-based treatment (dosing) guidelines for the use of low dose atropine for myopia control.
The specific objectives of this study are:
- To assess the effects of 0.01% atropine on pupil dilation and accommodation as a measure of active drug levels in the eye when dosed twice per week compared to daily
- To assess the subjective effects of 0.01% atropine on the subjects' vision
The study will involve one 60-minute screening session, twenty 15-minute testing sessions, and one 8-hour testing session, for a total of 14 hours over five to six weeks. Following the screening exam (information will be collected on the screening form), the subject will be randomly assigned to treat their non-dominant eye with:
- 0.01% daily dosing for two weeks followed by a 1-week washout then 0.01% twice per week for two weeks
- 0.01% twice per week dosing for two weeks, followed by a 1-week washout, then 0.01% daily for two weeks.
Test sessions (expected to be no more than 15 mins in length) will be held daily during the testing period and scheduled at the subject's convenience. Session measurements will include best-corrected visual acuity, subjective amplitude of accommodation, objective amplitude of accommodation, and pupil size, as described previously (see screening section 7b). An anterior segment slit lamp biomicroscopy exam will also be performed to ensure good ocular health. The subject will also be asked to fill out a brief symptom questionnaire (attached) while they are present for the test session. Information will be recorded on the data collection sheet for this portion of the testing.
Additionally, measurements of pupil size and accommodation will be taken prior to the instillation of a single dose of 0.01% atropine, and then at 1min, 5 min, 30 min, 1hr, 2hr, 4hr, and 8hr post-instillation.
Study Type
Enrollment (Actual)
Phase
- Phase 3
Contacts and Locations
Study Locations
-
-
California
-
Berkeley, California, United States, 94720-2020
- UC Berkeley, Department of Vision Science
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Participants must have vision that is correctable to 20/20 in each eye
- Participants must also have normal binocular vision (no history of manifest eye turns or eye surgeries to correct an eye turn)
- Participants must have normal accommodation (amplitude and facility within a normal range based on the subject's age)
- Participants must have normal ocular health
Exclusion Criteria:
- Previous chronic use of atropine
- Participants who are pregnant, plan to become pregnant, or are breastfeeding
- Sensitivity or allergy to atropine
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Other
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: 0.01% atropine daily
Nightly dosing of 0.01% atropine
|
Dosing frequency comparison, using atropine sulfate 1% solution diluted to 0.01% and 0.05% by Leiter's Compounding Pharmacy
Other Names:
|
Experimental: 0.01% atropine twice per week
Atropine dosed twice per week
|
Dosing frequency comparison, using atropine sulfate 1% solution diluted to 0.01% and 0.05% by Leiter's Compounding Pharmacy
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Change in pupil size at 1 week
Time Frame: Measured at baseline and again 1 week after first using drop
|
Measured at baseline and again 1 week after first using drop
|
Collaborators and Investigators
Investigators
- Principal Investigator: Maria Liu, OD, MPH, PhD, UC Berkeley
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Eye Diseases
- Refractive Errors
- Myopia
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Anti-Arrhythmia Agents
- Parasympatholytics
- Autonomic Agents
- Peripheral Nervous System Agents
- Muscarinic Antagonists
- Cholinergic Antagonists
- Cholinergic Agents
- Adjuvants, Anesthesia
- Bronchodilator Agents
- Anti-Asthmatic Agents
- Respiratory System Agents
- Pharmaceutical Solutions
- Mydriatics
- Ophthalmic Solutions
- Atropine
Other Study ID Numbers
- IND 128961
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Myopia
-
He Eye HospitalNot yet recruiting
-
University of BradfordCoopervision, Inc.; University of HuddersfieldNot yet recruiting
-
Visioneering Technologies, IncRecruitingMyopiaUnited States, Canada, Hong Kong, Singapore
-
University Eye Hospital, FreiburgRecruiting
-
Shanghai 10th People's HospitalCompletedMyopia | Myopia, ProgressiveChina
-
Tianjin Eye HospitalActive, not recruiting
-
Tianjin Eye HospitalCompleted
-
Sultan Qaboos UniversityChristian Medical College, Vellore, IndiaUnknown
-
Peking University People's HospitalUnknownProgressive MyopiaChina
-
Shanghai Eye Disease Prevention and Treatment CenterNot yet recruiting
Clinical Trials on Atropine
-
Washington University School of MedicineAmerican Diabetes AssociationCompletedPre-diabetesUnited States
-
Assiut UniversityCompleted
-
China Medical University, ChinaCompleted
-
University of UtahActive, not recruiting
-
Zhaoke (Guangzhou) Ophthalmology Pharmaceutical...Active, not recruiting
-
LitePharmTech Co., Ltd.RecruitingChildren | MyopiaKorea, Republic of
-
Hai Yen Eye CareBrien Holden VisionCompleted
-
Shanghai Eye Disease Prevention and Treatment CenterRecruiting
-
Memorial Sloan Kettering Cancer CenterSunnybrook Health Sciences CentreEnrolling by invitationHealthy VolunteersUnited States