Future Mental Projections in Schizophrenia (FutureProSchiz)

The aim of the study is to investigate temporal organization of future thinking in patients with schizophrenia. Patients and control participants will be asked to envision and briefly describe ten personal future events using a cue-words list. Then they will be asked to describe everything that came to their minds (i.e. to think aloud) while they attempted to determine when an event will likely occur. The investigators will compare the proportion of several predefined strategies mentioned by the two groups of participants to locate future events in time. The investigators predict that patients will envision less personal future events and will rely to a lesser extent on strategies to locate events in time, than control participants.

Study Overview

• Status: Terminated
• Conditions: Schizophrenia
• Intervention / Treatment: Other: questionnary

• Study Type: Observational
• Enrollment (Actual): 56

Contacts and Locations

Study Locations

• France
  • Strasbourg, France, 67000
    • Service de psychiatrie 1

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 55 years (Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

patients with Schizophrenia

Description

Inclusion Criteria:

• for patients only
• male or female
• age limits : 18-55 years old
• under the protection of health insurance
• who have signed up the consent form
• schizophrenia or schizo-affective disorder according to the DSM-5 criteria (APA, 2013).
• clinically stable for at least 2 months
• patients under guardianship or curatorship need agreement of their legal representative
• informed of the results of prior medical examination for controls only
• male or female
• age limits : 18-55 years old
• under the protection of health insurance
• who have sign up the consent form
• recruited from the general population and matched on gender, age years of schooling
• no psychiatric history (DSM-5)

Exclusion Criteria:

• for both patients and controls
• current severe or unstable somatic illness
• neurological history (brain injury > 15 minutes loss of consciousness , epilepsia, brain surgery…)
• current substance use disorder (DSM-5)
• current major depressive disorder (CDSS,BDI, HDRS)
• mental retardation (IQ < 70, WAIS-4, f-NART)
• history of general anesthesia 3 months prior to the experiment
• pregnancy declared by the subject
• breast feeding
• current legal control
• in emergency situation
• included during exclusion period in another experiment
• for controls only
• taking of antipsychotic drugs for the 3 weeks prior to inclusion
• under guardianship or curatorship

Study Plan

How is the study designed?

Design Details

• Observational Models: Other
• Time Perspectives: Prospective

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Patients with schizophrenia; Patients with schizophrenia or schizoaffective disorder according to DSM-V criteria	Other: questionnary; Participant's verbalization will be audio recorded and then transcribed by investigators. The investigators will use predefined categories to score the strategies mentioned by participants during the think aloud task.
Control participants; - Control participants without psychiatric nor neurological history	Other: questionnary; Participant's verbalization will be audio recorded and then transcribed by investigators. The investigators will use predefined categories to score the strategies mentioned by participants during the think aloud task.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Number of time location strategies	1 months

Collaborators and Investigators

• Sponsor: University Hospital, Strasbourg, France

Study record dates

Study Major Dates

• Study Start (Actual): April 5, 2017
• Primary Completion (Actual): October 20, 2019
• Study Completion (Actual): October 20, 2019

Study Registration Dates

• First Submitted: January 27, 2017
• First Submitted That Met QC Criteria: January 31, 2017
• First Posted (Estimated): February 2, 2017

Study Record Updates

• Last Update Posted (Actual): August 23, 2023
• Last Update Submitted That Met QC Criteria: August 21, 2023
• Last Verified: August 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Schizophrenia Spectrum and Other Psychotic Disorders; Schizophrenia
• Other Study ID Numbers: 6527

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No