General Anesthesia Management in 15 Preterm Infant

General Anesthesia Management in 15 Preterm Infant Undergoing Diode Laser Photocoagulation for Retinopathy of Prematurity: A Retrospective Study

Anesthesia management of preterm infants is challenging for the anesthesiologist. Because of rudimentary build, many medical and physical problems have shown in treatment of disease such as complications, airway problems, temperature disregulation and deficient drug metabolism. This retrospective study evaluates the perioperative management and postoperative course in premature infants undergoing diode laser photocoagulation (DLP) for retinopathy of prematurity (ROP).

Study Overview

• Status: Completed
• Conditions: Anesthesia Management of Premature Infants
• Intervention / Treatment: Other: general anesthesia management of preterm infants

Detailed Description

Participants retrospectively investigate clinical data and anesthesia process of 15 preterm infant from anesthesia charts with ROP who underwent DLP between 2014 and 2016. This presented retrospective study was confirmed by the Institutional Clinical Research Ethics Board. Neonates burns under 30 weeks gestation and low birth weigh under 2000 g were admitted to the study. No infant were excluded from the study. Preterm infants were appreciated before surgery and informed consent was obtained form their parents. We recorded gestational age, American Society of Anesthesiologists (ASA) physical status scores, post-conceptual age, weight at birth and surgery, duration of anesthesia and surgery, blood glucose values at surgery, the management of airway, total hospital stay period, analgesia management, complications and comorbidities. Bradycardia ( <90 beats/mean), desaturation (SpO2 <90%) and arrhythmia were recorded. Electrocardiography (ECG), pulse oximetric saturation (SpO2), end-tidal carbon dioxide pressure, heart rate (HR) and body temperature were monitored in operating room. Topical 0.5% proparacaine eye drops were administered to all infants routinely. Anesthesia was induced with thiopental 6 mg kg-1 and fentanyl 1 µg kg-1 and it was maintained with 50% oxygen 50% air 1%-3% sevoflurane in all cases. Inhaled anesthetic agent was not preferred for induction of anesthesia because of causing hypotension. The premature infants were intubated by same experienced anesthesiologist. In all infants, were intubated the patients without muscle relaxant under spontaneous ventilation. Perioperative complications, blood glucose value, devices in airway management and extubation value were recorded. After surgery, extubation was performed when spontanea ventilation was enough and extubation was recorded. All infants were taken to newborn intensive care unit (NICU). Data are reported as mean ± standard deviation and percentage(%).

• Study Type: Observational
• Enrollment (Actual): 15

Contacts and Locations

Study Locations

• Turkey
  • Malatya, Turkey, 44090
    • Inonu University Medical Faculty

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: No older than 3 years (Child)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

patiens who were operated about retinopathy of premature.

Description

Inclusion Criteria:

• all preterm infants who was decided to apply ROP

Exclusion Criteria:

• No patient was excluded

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Control
• Time Perspectives: Retrospective

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Characteristics of Anesthesia management; Evaluate the average value of these data.	Other: general anesthesia management of preterm infants; general anesthesia management of preterm infants
Comorbidities; Evaluate the average value of these data.	Other: general anesthesia management of preterm infants; general anesthesia management of preterm infants

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
the management of airway	the management of airway	up to 2 years
gestational age	gestational age	up to 2 years
American Society of Anesthesiologists physical status scores	American Society of Anesthesiologists physical status scores	up to 2 years
post-conceptual age	post-conceptual age	up to 2 years
weight at birth and surgery	weight at birth and surgery	up to 2 years
duration of anesthesia and surgery	duration of anesthesia and surgery	up to 2 years

Collaborators and Investigators

• Sponsor: Inonu University

Study record dates

Study Major Dates

• Study Start: December 1, 2016
• Primary Completion (Actual): January 1, 2017
• Study Completion (Actual): January 1, 2017

Study Registration Dates

• First Submitted: December 1, 2016
• First Submitted That Met QC Criteria: February 2, 2017
• First Posted (Estimate): February 7, 2017

Study Record Updates

• Last Update Posted (Estimate): February 9, 2017
• Last Update Submitted That Met QC Criteria: February 7, 2017
• Last Verified: February 1, 2017

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Physiological Effects of Drugs; Central Nervous System Depressants; Anesthetics
• Other Study ID Numbers: ASOZKAN-1

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: Yes