Clinical Trial for Vespa Amino Acid Mixture (VAAM®)

Improved ATP Generation Efficiency for Younger Athletes by Ingestion of a Vespa Amino Acid Mixture

ATP is generated mainly through anaerobic metabolism during strenuous exercise, which is then followed by the generation of lactic acid. However, this process can only be maintained for a short time, approximately one minute, because the accumulation of lactic acid in the muscles may affect muscle performance. The efficiency of lactic acid metabolism is one of the most important reasons for endurance improvement. The purpose of this study was to evaluate the impacts of the daily ingestion of a commercially available Vespa amino acid mixture (VAAM®) beverage on blood parameters that are related to fatigue, muscle damage and immunity in healthy, young athletes during middle-distance running exercises. VAAM® contains 17 types of amino acids at a certain ratio, and evaluations were completed during 10 weeks of consecutive required speed and strength running tests.

Study Overview

• Status: Completed
• Conditions: Sports Injury
• Intervention / Treatment: Dietary supplement: Vespa amino acid mixture

Detailed Description

The subjects were instructed to maintain their usual dietary habits in addition to drinking VAAM® (two cans every day) for 10 weeks. In detail, on the 6 days/week of supervised running tests, participants were instructed to consume one drink before their warm-up exercise and the other drink while running. During their sessions and without supervision (1 day/week), participants were also instructed to consume one drink in the morning after breakfast and the other drink in the evening after dinner.

The subjects were divided into three groups for the running tests: 3 males were assigned to group 1, which involved training for the 1500-meter race; 2 males were assigned to group 2, which involved training for the 800-meter race; and 1 male and 3 females were assigned to group 3, which involved training for the 400-meter race. The running exercises began with a 45 min warm-up (including jogging, leg stretching, etc.) followed by running their specific races. The experimental procedure was conducted 6 days/week for 10 weeks.

• Study Type: Interventional
• Enrollment (Actual): 10
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years to 18 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Athletes from 16 to 18 years old;
• Subjects underwent a physical examination before enrollment and showed no sign of illness or malaise.

Exclusion Criteria:

• Subjects were smokers or ergogenic aid users;
• Subjects had any metabolic, cardiovascular, renal, or liver diseases;
• Subjects had psychiatric disorders.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Health Services Research
• Allocation: Non-Randomized
• Interventional Model: Sequential Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Subjects ingested VAAM® for 10 weeks; Ten young athletes ingested Vespa amino acid mixture (VAAM®) for 10 weeks, divided into different meter race including 1500-, 800- and 400-meter races.	Dietary supplement: Vespa amino acid mixture; 17 kinds of amino acids mixture in specific proportion; Other Names: VAAM®
Experimental: Subjects ingested VAAM® for 6 weeks; Ten young athletes ingested Vespa amino acid mixture (VAAM®) for 6 weeks, divided into different meter race including 1500-, 800- and 400-meter races.	Dietary supplement: Vespa amino acid mixture; 17 kinds of amino acids mixture in specific proportion; Other Names: VAAM®
No Intervention: Subjects ingested nothing; Ten young athletes before ingesting Vespa amino acid mixture (VAAM®) , divided into different meter race including 1500-, 800- and 400-meter races.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
change of running time scores at 10 weeks	10 weeks
change of the plasma lactic acid clearance rate after running at 10 weeks	10 weeks
change of red blood cells after running at 10 weeks	10 weeks

Collaborators and Investigators

• Sponsor: Shanghai Meiji Health Science and Technology Co., Ltd.

Study record dates

Study Major Dates

• Study Start (Actual): May 2, 2009
• Primary Completion (Actual): July 16, 2009
• Study Completion (Actual): July 22, 2009

Study Registration Dates

• First Submitted: April 1, 2017
• First Submitted That Met QC Criteria: April 18, 2017
• First Posted (Actual): April 19, 2017

Study Record Updates

• Last Update Posted (Actual): April 19, 2017
• Last Update Submitted That Met QC Criteria: April 18, 2017
• Last Verified: April 1, 2017

More Information

Terms related to this study

• Keywords: Nutrition; Young athletes; ATP; Vespa amino acid mixture (VAAM®); lactic acid accumulation; Anaerobic metabolism; Sports damage
• Additional Relevant MeSH Terms: Wounds and Injuries; Athletic Injuries
• Other Study ID Numbers: 0002

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No