Anticholinergic Risk Scale and Resource Use After Elective Noncardiac Surgery

November 22, 2024 updated by: Dan McIsaac, Ottawa Hospital Research Institute

Association of Anticholinergic Risk Scale and Healthcare Resource Use After Elective Noncardiac Surgery: a Population-based Cohort Study

This study investigates the association of preoperative anticholinergic medication exposure with healthcare resource utilization in a population-based sample of older patients enrolled in a universal pharmacare program

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Multilevel multivariable regression analysis will be used to investigate the adjusted association between preoperative Anticholinergic Risk Scale and postoperative healthcare resource utilization. Sensitivity analyses will be used to evaluate the robustness of the primary analysis.

Study Type

Observational

Enrollment (Actual)

244976

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Canada
    • Ontario
      • Ottawa, Ontario, Canada, K1Y4E9
        • Ottawa Hospital Research Institute

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Population-based sample of people having their first eligible surgery during the study period

Description

Inclusion Criteria:

  • at least 66 years old on the day of surgery
  • Intermediate to high risk elective noncardiac surgery

Exclusion Criteria:

-

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
No anticholinergic exposure
People with an anticholinergic risk scale score of 0
Moderate anticholinergic exposure
People with an anticholinergic risk scale score of 1-2
Other: anticholinergic risk scale
Risk summation scale for grading and studying anticholinergic medication exposure
High anticholinergic exposure
People with an anticholinergic risk scale score of >=3
Other: anticholinergic risk scale
Risk summation scale for grading and studying anticholinergic medication exposure

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Hospital Length of Stay
Time Frame: date of surgery to date of hospital discharge, or 365 days after surgery, whichever comes first
Number of days in hospital after surgery
date of surgery to date of hospital discharge, or 365 days after surgery, whichever comes first

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Mortality
Time Frame: from day of surgery up to 90 days after surgery
death from any cause
from day of surgery up to 90 days after surgery
Costs of Care
Time Frame: date of surgery up to 90 days after surgery
Costs related to medical care paid for by the provincial health insurance system
date of surgery up to 90 days after surgery
Institutional Discharge
Time Frame: date of surgery to date of hospital discharge, or 365 days after surgery, whichever comes first
A discharge location at the end of the surgical episode of care that is not back to the patient's original residence (specifically respite or long term care)
date of surgery to date of hospital discharge, or 365 days after surgery, whichever comes first
Hospital Readmission
Time Frame: From the date of hospital discharge to 30 days after the date of discharge
Acute hospital readmission after discharge from index hospitalization
From the date of hospital discharge to 30 days after the date of discharge

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ottawa Hospital Research Institute

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 1, 2003

Primary Completion (Actual)

March 31, 2014

Study Completion (Actual)

March 31, 2014

Study Registration Dates

First Submitted

May 10, 2017

First Submitted That Met QC Criteria

May 11, 2017

First Posted (Actual)

May 12, 2017

Study Record Updates

Last Update Posted (Actual)

March 25, 2025

Last Update Submitted That Met QC Criteria

November 22, 2024

Last Verified

October 1, 2024

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • DM6

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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