Fish, Polyunsaturated Fatty Acids Intake and Mortality

March 12, 2024 updated by: Jingjing Jiao, Zhejiang University

Fish, Polyunsaturated Fatty Acids Intake and Mortality: Analysis of CHNS and NHANES

Data linking fish, polyunsaturated fatty acids intake and mortality are lacking and conflicting. We aim to use data from the China Health and Nutrition Survey (CHNS) and National Health and Nutrition Examination Survey (NHANES) to investigate the associations of fish and polyunsaturated fatty acids (PUFA) intake with mortality in Chinese and US populations. The study findings will be informative for addressing the role of fish and specific PUFA in human health and improve basis for dietary recommendations.

Study Overview

Status

Completed

Conditions

Detailed Description

Data from the China Health and Nutrition Survey (CHNS, from 1989 to 2011) and National Health and Nutrition Examination Survey (NHANES), including NHANES III conducted in 1988-1994 and continuous NHANES 1999-2010 were used to investigate the associations of fish and polyunsaturated fatty acids intake with mortality.The following variables were used:

  1. Demographics: age, sex, race/ethnicity, residence
  2. Socioeconomic variables: education, marital status,
  3. Dietary variables: Intakes of fish, polyunsaturated fatty acids, total energy, vegetables, fruits, red meat and saturated fat
  4. Clinical assessments: hypertension, diabetes, cancer, cardiovascular disease (CVD), family history of CVD

Study Type

Observational

Enrollment (Actual)

50145

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

CHNS is an ongoing, large-scale, household-based cohort starting in 1989. The survey used a multi-stage, random cluster process to draw a sample of 9 provinces and municipal cities, which take up about half of Chinese population. NHANES is also a nationally-representative study of nutrition and health for individuals residing in the U.S. Our study included participants in CHNS and NHANES who met the eligibility criteria.

Description

Inclusion Criteria:

  • Adults aged ≥20 with complete data on diet and follow-up time

Exclusion Criteria:

  • Missing information for mortality
  • Cardiovascular disease
  • Cancer

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
CHNS
NHANES

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Total Mortality
Time Frame: From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years
Total Mortality from All Causes
From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Cause-specific mortality
Time Frame: From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years
Cause-specific mortality from diseases
From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Zhejiang University

Collaborators

National Institute of Health and Nutrition

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 1989

Primary Completion (Actual)

December 1, 2011

Study Completion (Actual)

July 1, 2012

Study Registration Dates

First Submitted

May 13, 2017

First Submitted That Met QC Criteria

May 13, 2017

First Posted (Actual)

May 16, 2017

Study Record Updates

Last Update Posted (Actual)

March 15, 2024

Last Update Submitted That Met QC Criteria

March 12, 2024

Last Verified

March 1, 2024

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • Cohort_PUFA

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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