- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03178903
tDCS for Increasing Exercise Adherence in Depressed Individuals (StRIDE)
tDCS for Increasing Exercise Adherence in Individuals With Elevated Depressive Symptoms
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Exercise adherence is a significant public health problem. Affective experiences during exercise predict long-term physical activity (PA) levels. Therefore, approaches to improving the affective experience of exercise are both important and likely to have high impact. This may be particularly true among individuals with elevated depressive symptoms due to their tendency toward more negative and less positive affect. tDCS is a noninvasive brain stimulation approach with a growing body of literature supporting its effects on cognitive and emotional processing in varied populations, including some support for those with depression. In addition, there is recent increased interest in utilizing tDCS in the context of exercise (see above) and in obesity prevention. While the effects of tDCS on behavioral and cognitive functioning are still developing, promising findings have emerged for tDCS used in repeated combination with a behavioral or cognitive intervention. Given that tDCS is relatively safe, inexpensive, and portable, individuals who struggle with enjoying exercise could be afforded a practical option for increasing and maintaining physical activity levels.
We propose to conduct a pilot randomized controlled trial of tDCS versus sham delivered 3x/week for 8 weeks in the context of a supervised aerobic exercise (AE) program among 72 low-active individuals with elevated depressive symptoms. Follow-up assessments will be conducted at end of treatment, 3, and 6 months.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
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Rhode Island
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Providence, Rhode Island, United States, 02906
- Butler Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- be between 18 and 65 years of age
- be low active
- have elevated levels of depressive symptoms
- interested in starting an exercise program in the next month
Exclusion Criteria:
- history of mania or hypomania
- current psychotic disorder
- current DSM-5 diagnosis of an eating disorder
- DSM-5 moderate and severe substance use disorder
- current suicidality or homicidality
- current DSM-5 diagnosis of major depressive disorder that is not currently being treated with pharmacotherapy or psychotherapy
- physical disabilities or medical problems that would prevent participation in moderate intensity exercise or may be contraindicated for tDCS
- current pregnancy or intent to become pregnant during the next 8 weeks
- pacemaker or metal implanted in the cranial cavity
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: tDCS and Aerobic Exercise
Each participant will undergo a 20-minute session of transcranial direct current stimulation (tDCS) delivered to the dorsolateral prefrontal cortex (DLPFC).
Each session of tDCS will be immediately followed by a supervised 30-minute, moderate-intensity bout of exercise.
These procedures will occur 3x/week for 8 weeks.
|
Participants in transcranial direct current stimulation (tDCS) will receive tDCS over the dorsal-lateral prefrontal cortex for 20 minutes, 3 times per week for 8 weeks.
Participants will engage in supervised, 30-minute bouts of moderate-intensity exercise 3x/week for 8 weeks.
|
Sham Comparator: Sham tDCS and Aerobic Exercise
Each participant will undergo a 20-minute session of sham transcranial direct current stimulation (tDCS) delivered to the dorsolateral prefrontal cortex (DLPFC).
Each session of tDCS will be immediately followed by a supervised 30-minute, moderate-intensity bout of exercise.
These procedures will occur 3x/week for 8 weeks.
|
Participants will engage in supervised, 30-minute bouts of moderate-intensity exercise 3x/week for 8 weeks.
Participants in sham transcranial direct current stimulation (tDCS) will receive shame tDCS over the dorsal-lateral prefrontal cortex for 20 minutes, 3 times per week for 8 weeks.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Physical Activity Levels
Time Frame: 8 week assessment
|
Accelerometry-based moderate-to-vigorous physical activity (MVPA)
|
8 week assessment
|
Collaborators and Investigators
Sponsor
Collaborators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 1608-002
- R21CA214102 (U.S. NIH Grant/Contract)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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