Amino-acid Uptake After Meat Protein Intake

Amino-acid Uptake After Hydrolyzed Meat Protein Intake in Healthy Elderly

The purpose of the project is to provide evidence for the use of hydrolysed meat protein (HMP) as a protein supplement for elderly who has difficulty meeting the recommended daily protein intake.

The study will investigate how the meat protein derived amino acids (from either HMP, steak or minced meat) are absorbed and released into the blood circulation of elderly persons. Hereby, the study will explore the the anabolic potential of HMP compared with common meat products.

Study Overview

• Status: Completed
• Conditions: Amino Acid Metabolism
• Intervention / Treatment: Dietary supplement: Meat protein absorption

• Study Type: Interventional
• Enrollment (Actual): 12
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Denmark
  • Copenhagen, Denmark, DK-2400
    • Institute of Sports Medicine Copenhagen

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Healthy
• Untrained

Exclusion Criteria:

• below 65 years of age
• BMI above 30
• Smokers
• Vegetarians
• Subjects with diabetes or other metabolic diseases
• Medical treatment affecting protein synthesis
• Gastro-intestinal problems, reduced liver or kidney function, elevated blood pressure, atherosclerosis
• More than 5 ours regular physical activity per week (except physical activity related to commuting)

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Double

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Hydrolyzed meat protein; D5-phenylalanine intrinsically labelled hydrolyzed meat protein (0.6 g per kg lean body mass), which will be consumed together with a full meal.	Dietary supplement: Meat protein absorption; Meat protein absorption when digested together with a full meal.
Experimental: Minced Meat; D5-phenylalanine intrinsically labelled hydrolyzed meat protein (0.6 g per kg lean body mass), which will be consumed together with a full meal.	Dietary supplement: Meat protein absorption; Meat protein absorption when digested together with a full meal.
Experimental: Beef; D5-phenylalanine intrinsically labelled hydrolyzed meat protein (0.6 g per kg lean body mass), which will be consumed together with a full meal.	Dietary supplement: Meat protein absorption; Meat protein absorption when digested together with a full meal.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
D5-phenylalanine appearance	D5-phenylalanine appearance in the blood circulation after meal consumption	5 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Insulin concentration	Insulin concentration in the blood circulation after meal consumption	5 hours

Collaborators and Investigators

• Sponsor: Bispebjerg Hospital
• Collaborators: DC Ingredients
• Investigators: Principal Investigator: Jakob Agergaard, PhD, Institute of Sports Medicine, Copenhagen

Study record dates

Study Major Dates

• Study Start (Actual): October 4, 2017
• Primary Completion (Actual): January 30, 2018
• Study Completion (Actual): October 30, 2019

Study Registration Dates

• First Submitted: September 28, 2017
• First Submitted That Met QC Criteria: October 3, 2017
• First Posted (Actual): October 4, 2017

Study Record Updates

• Last Update Posted (Actual): November 21, 2022
• Last Update Submitted That Met QC Criteria: November 18, 2022
• Last Verified: November 1, 2022

More Information

Terms related to this study

• Keywords: Aging; Meat protein; Amino acid uptake
• Other Study ID Numbers: BBH 135

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No