rTMS Posterior Parietal Cortex Modulation and Upper Limb Movement After Stroke (PPCstim)

Influence of the Modulation of the Posterior Parietal Cortex (rTMS) on a Pointing Movement With the Paretic Upper Limb After Stroke

This study evaluates the effect of a unique session of inhibitory rTMS (cTBS) over the contralesional posterio parietal cortex (PPC) on the spatio-temporal parameters of a pointing movement performed by stroke patients with their paretic upper limb. It will also assess the effects on the resting motor threshold of both hemispheres and on parietopremotor connectivity.

To achieve theses aims, the real cTBS stimulation will be randomly counterbalanced with a SHAM stimulation (in a second session) in a crossover design. Assessments will be performed before and after each stimulation session.

Study Overview

• Status: Terminated
• Conditions: Stroke; Transcranial Magnetic Stimulation; Hemiparesis; Brain Connectivity
• Intervention / Treatment: Device: repeated transcranial magnetic stimulation continuous theta-burst stimulation; Device: SHAM repeated transcranial magnetic stimulation

• Study Type: Interventional
• Enrollment (Actual): 1
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Lille, France, 59037
    • Hôpital Swynghedauw, CHU lille

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Age between 18 and 80y
• Right-handed
• Right hemispheric stroke confirmed by a 3D imaging technique
• at the chronic phase (>6months)
• subject being able to perform a pointing movement of at least 20cm in the anterior space without compensatory movements of the trunk
• informed consent
• Social security affiliation

Exclusion Criteria:

• Severe comprehension troubles (language, cognitive or psychiatric disorders)
• History of neurological disorders in addition to the stroke
• Locomotor troubles affecting the paretic arm
• Contraindication to rTMS : epilepsy, intracranial metallic foreign body, cochlear implant, unstable fracture of the skull bones, deafness
• pregnancy or breastfeeding
• adult subject to guardianship

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: cTBS stimulation; continuous theta-burst TMS stimulation (1200 pulses, 50Hz, separated in two sequences of 600 pulses)	Device: repeated transcranial magnetic stimulation continuous theta-burst stimulation; cTBS
Sham Comparator: SHAM stimulation (placebo); SHAM stimulation	Device: SHAM repeated transcranial magnetic stimulation; SHAM stimulation

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time of movement during the pointing movement	Time between the initiation of the movement and the reaching of the target	30 minutes

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Reaction time (time between the go signal and th onset of the movement)	temporal parameters of pointing movements	30 minutes
Response time (time between the go signal and the reaching of the target)	temporal parameters of pointing movements	30 minutes
Peak velocity of the hand during the pointing movement	pak velocity in m/s	30 minutes
smoothness (number of units of movement during the pointing movement),	Spatial parameters of pointing movements	30 minutes
Linearity (ration between the length of the trajectory of the hand and the linear distance between the initial position of the hand and the target)	Spatial parameters of pointing movements	30 minutes
Detection of mirror movements with the healthy upper limb	EMG detection	30 minutes
Primary motor cortex excitability of both motor cortices	Resting motor threshold of lesioned and non-lesioned hemispheres	30 minutes
Parietomotor connectivity in the contralesional hemisphere	Assessed by a paired-pulse TMS protocol (see Allart et al. 2017 for more details)	30 minutes
Spatial bias	Line bisection test	30 minutes

Collaborators and Investigators

• Sponsor: University Hospital, Lille
• Investigators: Principal Investigator: Etienne Allart, MD, University Hospital, Lille

Study record dates

Study Major Dates

• Study Start (Actual): March 10, 2020
• Primary Completion (Actual): August 1, 2021
• Study Completion (Actual): August 1, 2021

Study Registration Dates

• First Submitted: October 16, 2017
• First Submitted That Met QC Criteria: October 23, 2017
• First Posted (Actual): October 26, 2017

Study Record Updates

• Last Update Posted (Actual): May 15, 2026
• Last Update Submitted That Met QC Criteria: May 12, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neurologic Manifestations; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Stroke; Paresis
• Other Study ID Numbers: 2016_36; 2016-A01608-43 (Other Identifier: ID-RCB number, ANSM)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No