- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03387956
Intrathecal Atropine to Prevent Postoperative Nausea and Vomiting
June 4, 2018 updated by: Emad Zarief , MD, Assiut University
Intravenous Dexamethasone Combined With Intrathecal Atropine to Prevent Morphine-related Nausea and Vomiting After Cesarean Delivery: A Randomized Double-blinded Study
optimal postoperative pain control with intrathecal morphine, with proper prevention of postoperative nausea and vomiting.
Dexamethasone, and or atropine could offer some protection against nausea and vomiting.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
One of the gold standards for analgesia following cesarean delivery is intrathecal morphine, which is not devoid of complications namely postoperative nausea and vomiting.
We evaluated the antiemetic effect of intravenous dexamethasone combined with intrathecal atropine after cesarean delivery under spinal bupivacaine plus morphine anesthesia.
Study Type
Interventional
Enrollment (Actual)
120
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Assiut, Egypt, 71111
- Emad Zarief Kamel Said
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 38 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Female
Description
Inclusion Criteria:
- females
- 18-40 years of age
- elective cesarean delivery under bupivacaine spinal anesthesia
Exclusion Criteria:
- renal disease
- preeclampsia
- liver disease
- cardiac disease
- Coagulopathy
- chronic cough
- nausea
- vomiting
- patient refusal
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Atropine group
Atropine group (A): Patients received intrathecal heavy Marcaine, 2 ml, 0.5% plus 300 µg morphine and 100 µg atropine (0.5ml), and intravenous injection of 2ml normal saline.
|
100ug intrathecal atropine will be injected with spinal anesthesia
|
Active Comparator: Dexamethasone group
Dexamethasone group (D): Patients received intrathecal heavy Marcaine 2 ml, 0.5% plus 300 µg morphine (0.5ml), and intravenous 8 mg dexamethasone (2ml).
|
intravenous 8 mg dexamethasone (2ml).
|
Active Comparator: Dexamethasone and Atropine group
Dexamethasone and Atropine group (DA): Patients received intrathecally as group A, plus intravenous injection of 2 ml, dexamethasone 8 mg.
Postoperative follow-up of both nausea and vomiting was done over 24 hours postoperative.
|
100ug intrathecal atropine will be injected with spinal anesthesia
intravenous 8 mg dexamethasone (2ml).
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
postoperative nausea
Time Frame: 24 hours
|
Monitoring scale of nausea and vomiting
|
24 hours
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
March 20, 2017
Primary Completion (Actual)
July 28, 2017
Study Completion (Actual)
August 10, 2017
Study Registration Dates
First Submitted
December 20, 2017
First Submitted That Met QC Criteria
December 24, 2017
First Posted (Actual)
January 2, 2018
Study Record Updates
Last Update Posted (Actual)
June 6, 2018
Last Update Submitted That Met QC Criteria
June 4, 2018
Last Verified
June 1, 2018
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Pathologic Processes
- Postoperative Complications
- Signs and Symptoms, Digestive
- Nausea
- Vomiting
- Postoperative Nausea and Vomiting
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Anti-Arrhythmia Agents
- Parasympatholytics
- Autonomic Agents
- Peripheral Nervous System Agents
- Muscarinic Antagonists
- Cholinergic Antagonists
- Cholinergic Agents
- Anti-Inflammatory Agents
- Antineoplastic Agents
- Antiemetics
- Gastrointestinal Agents
- Glucocorticoids
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Antineoplastic Agents, Hormonal
- Adjuvants, Anesthesia
- Bronchodilator Agents
- Anti-Asthmatic Agents
- Respiratory System Agents
- Mydriatics
- Dexamethasone
- Atropine
Other Study ID Numbers
- IRB00009916
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Undecided
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Postoperative Nausea
-
Cukurova UniversityTarsus UniversityRecruitingNausea, Postoperative | Vomiting, Postoperative | APFEL RİSK SCORETurkey
-
Ospedale Misericordia e DolceUnknownPostoperative Pain | Thyroidectomy | Postoperative Nausea and Vomit | Postoperative Vocal FunctionItaly
-
Lancaster General HospitalCompletedBariatric Surgery Candidate | Nausea, PostoperativeUnited States
-
Northwell HealthTerminatedPostoperative Pain | Postoperative Nausea | Postoperative VomitingUnited States
-
Hôpital Privé de Parly II - Le ChesnayCompletedPostoperative Nausea | Postoperative Vomiting | Postoperative EmesisFrance
-
Yeungnam University College of MedicineCompletedPostoperative Nausea | Postoperative VomitingKorea, Republic of
-
Methodist Health SystemRecruitingNausea, Postoperative | Vomiting, PostoperativeUnited States
-
Sevgi GürCompletedPostoperative Nausea and VomitingTurkey
-
Khon Kaen UniversityCompleted
Clinical Trials on Intrathecal atropine
-
Washington University School of MedicineAmerican Diabetes AssociationCompletedPre-diabetesUnited States
-
Tisch Multiple Sclerosis Research Center of New...CompletedMultiple SclerosisUnited States
-
Moens MaartenCompleted
-
International Stemcell Services LimitedCompletedSpinal Cord InjuriesIndia
-
Royan InstituteCompletedAmyotrophic Lateral SclerosisIran, Islamic Republic of
-
Tisch Multiple Sclerosis Research Center of New...No longer available
-
Hospital Universitario Dr. Jose E. GonzalezCompletedAmyotrophic Lateral SclerosisMexico
-
Centre Hospitalier Universitaire de NiceActive, not recruitingSpinal Muscular AtrophyFrance
-
Dr med. Paolo Maino Viceprimario AnestesiologiaVU University of AmsterdamCompleted